125results about How to "Increase excitability" patented technology

The present invention relates to methods for modulating progestagen signaling for treating neurological disorders or neurodegenerative disease, or preventing or delaying its onset in individuals deemed by competent observation and testing to be susceptible thereto. Progestagens can be administered to elevate serum and brain levels of progestagens and induce neurogenesis. Progestagen therapy may prevent some of the neurodegenerative and cognitive changes associated with developmental and aging associated neurological disorders and neurodegenerative diseases. Progestagen therapy together with suppression of GnRH, kisspeptin, LH and / or FSH signaling also may be used for treating neurological disorders or neurodegenerative diseases. The invention also relates to methods for inhibiting or delaying blastulation during embryogenesis, and neurogenesis during embryogenesis, fetal, neonatal, childhood, puberty or adult life. Blocking progestagen, estrogen and / or opioid signaling with receptor antagonists will inhibit neurogenesis. The invention also relates to using progestagens in vitro to induce neurogenesis in embryonic or adult stem cells.

A neuromodulation lead, comprising an elongated body, at least one electrode carried by the distal end of the elongated body, and at least one optical element carried by the distal end of the elongated body. The electrode(s) is configured for conveying electrical energy capable of modulating a neuronal element, and the optical element(s) is configured for conveying low-level laser energy capable of modulating a neuronal element. A method of treating a patient with an ailment comprises conveying electrical energy to a first neuronal element, thereby modulating the first neuronal element, and conveying low-level laser energy having a wavelength in the range of 600 nm-2500 nm to the first neuronal element, thereby modulating the first neuronal element. At least one of the conveyance of the electrical energy and the conveyance of the low-level laser energy treats the ailment.

A method of treating a patient with an ailment using an optical element implanted within the patient, comprising conveying low-level laser energy having a wavelength in the range of 600 nm-2500 nm from the optical element to a neuronal element of the patient, thereby modulating the neuronal element to treat the ailment.

A method for treating a patient suffering from loss of muscle control and / or function in a body region after a stroke includes epidurally applying electrical stimulation to a spinocerebellar tract of the patient (e.g., at or above the vertebral level of the spinal cord where the sensory and motor mapping for the body region are located), thereby increasing cortical excitability and facilitating the patient regaining muscle control and / or function in the body region. The method may include using cortical mapping to determine a cortical region having a residual motor response in or near the body region, implanting an electrode in a lateral epidural space, and applying the electrical stimulation in a manner that causes excitability in the cortical region having the residual motor response, wherein the stimulation is applied by the implanted electrode. The method may include exercising the body region while simultaneously applying the electrical stimulation.

This invention relates to the 5-cis and 5-trans isomers of geranylgeranyl acetone, preferably such synthetic isomers, and pharmaceutical compositions containing such isomers. Other aspects of this invention relate to the use of geranylgeranyl acetone and its isomers in methods for inhibiting neural death, increasing neural activity, and increasing axon growth and cell viability. Geranylgeranyl acetone is a known anti-ulcer drug used commercially and in clinical situations. GGA has also been shown to exert cytoprotective effects on a variety of organs, such as the eye, brain, and heart.

The invention relates to a moistening and moisturizing essence, which is prepared from the following components in percentage by weight: a component A: 20.1 to 31.3 percent of a moisturizer, 5 to 10 percent of thermal spring water and 0.48 to 0.7 percent of a preservative; a component B: 3.2 to 5.35 percent of a moistening agent; a component C: 0.08 percent of a solubilizer and 2 to 4 percent of an odor remover; a component D: 2.51 to 6.02 percent of a skin conditioning agent and 3.05 to 5.1 percent of a skin penetration promoter. The invention also discloses a preparation method for the moistening and moisturizing essence. The moistening and moisturizing essence is mild and nonirritating in component formula and high in skin penetration, and has synergistic effects, rapid and persistent moisturizing and moisture locking effects and the effects of obviously softening skin and delaying senescence, and the skin can be moistened most rapidly and effectively.

A new method for curative radiofrequency AF ablation to achieve the inactivation or distruction of fibrillar myocarcium and of the AF nests. In addition, evidence that fibrillar myocardium could be of the real AF substratum was found. Identified and mapped by spectral analysis and phase study of the tissue, which seems to have intermediate features between nervous and myocardium. The procedure by transeptal puncture which requires only one catheter for ablation and mapping. The new method may be localize the application targets even during arrhythmia.

The invention discloses an antioxidant solid drink containing haematococcus pluvialis and blackcurrant powder. The antioxidant solid drink comprises the following components in parts by weight: 0.1-6.0 parts of haematococcus pluvialis, 3-10 parts of blackcurrant juice powder, 3-10 parts of cranberry juice powder, and 3-10 parts of blueberry juice powder. Through the synergistic effect and mutual promotion of antioxidant components, the antioxidant effect of the solid drink is improved, the cost of raw materials is greatly reduced, and meanwhile, the antioxidant solid drink has the functions of promoting appetite, maintaining normal activity of nerve, protecting visual function and the like.

Aspects of the disclosure relate to methods for treating disorders using agents for promoting hypoglossal motoneuron excitability. In some instances the disorders include obstructive sleep apnea (OSA), cataplexy, attention deficit / hyperactivity disorder (ADHD), attention deficit disorder (ADD) or depression. Related products are also included within the invention.

The invention provides a food health product for improving sleep and a preparation method thereof. The food health product is prepared from the following components in parts by weight: 30-50 parts of spine date seed extract, 10-20 parts of broken spore ganoderma lucidum powder, 5-15 parts of gamma-aminobutyric acid powder, 5-10 parts of Indian buead extract, 5-10 parts of thinleaf milkwort root extract, 12-16 parts of lily bulb extract, 1-4 parts of fructus shisandrae extract, 3-6 parts of pearl powder extract, 4-8 parts of oyster shell power, 10-15 parts of magnesium stearate and 0.1-0.5 part of vitamin B6. The invention overcomes the defects in the prior art and provides a health product for improving sleep, and the food health product is simple in formula and reasonable in compatibility of medicines and accords with the principle of syndrome differentiation of traditional Chinese medicine, and the medicines in the formula supplement each other and have obvious effects of improving the sleep.

A tea cigarette features that its threds are made of tea leaves, roasted barley bran, ginger oil, cinnamon bark oil, origanum herb oil, coffeine, allyl isothiocyanate, etc. Its advantages are no damage to human health and good enjoyment to smoke it.

The invention provides a motor imagery brain-computer interface control method based on noninvasive electrical stimulation. The control method comprises the following steps: applying anode noninvasive brain function electrical stimulation on the primary motor cortex of a user; collecting an electroencephalography original signal after the user executes a motor imagery task, and extracting an event-related desynchronization signal and / or event-related synchronization signal from the electroencephalography original signal; carrying out quantification processing on the event-related desynchronization signal and / or event-related synchronization signal to obtain the average power of the event-related desynchronization signal and / or event-related synchronization signal in a Lower[Mu] waveband, an Upper[Mu] waveband and a [Beta] waveband; carrying out feature extraction on the event-related desynchronization signal and / or event-related synchronization signal to obtain the feature values of the event-related desynchronization signal and / or event-related synchronization signal; and according to the average power, classifying the feature values to obtain a control instruction, wherein the control instruction is used for controlling a feedback training normal form.

An intelligent watch and bracelet capable of preventing snoring comprise a shell body, a power supply circuit and a function circuit. The shell body is provided with a control key and a display device. The intelligent watch and bracelet are characterized in that the intelligent watch and bracelet are electrically connected with an intelligent snoring-stopping device which comprises a conducting rubber piece, an audio frequency detector, an adjusting device and a printed-circuit board. The conducting rubber piece is arranged in the position, in contact with a human body, of the back face of the shell body. The audio frequency detector is arranged in the shell body. The output end of the audio frequency detector is electrically connected to the input end of the printed-circuit board through a signal amplifier. The display device, the control key, the adjusting device, the conducting rubber piece and the audio frequency detector are electrically connected to the printed-circuit board which is connected with the power supply circuit. By adding the intelligent snoring-stopping device, influence of snoring on people is relieved, sleeping quality is improved, and the intelligent watch and bracelet have the advantages of being simple in operation and convenient to wear, and the human body is protected from damage.

The invention provides a cranial nerve stimulating device for enhancing a cognitive function of a brain. The device comprises a frequency tunable high-frequency electromagnetic wave source, a beam shaping unit, an optical fiber coupler, a multi-dimensional fine tuning platform, an optical fiber, and an electrophysiology detecting device. The frequency tunable high-frequency electromagnetic wave source is used for generating high-frequency electromagnetic pulses. The beam shaping unit is used for shaping and focusing the high-frequency electromagnetic pulses generated by the frequency tunable high-frequency electromagnetic wave source to the input end of the optical fiber. The optical fiber coupler is used for fixing the input end of the optical fiber. The multi-dimensional fine tuning platform is used for fine tuning and aligning the input end of the optical fiber and a light spot. The optical fiber is used for receiving the high-frequency electromagnetic pulses and introducing the high-frequency electromagnetic pulses into the cranial nerve system through the output end of the optical fiber. The electrophysiology detecting device is used for detecting the tissue activity after thecranial nerve system is stimulated by the high-frequency electromagnetic pulses. According to the cranial nerve stimulating device for enhancing the cognitive function of the brain, the minimally invasive, high-targeting and high-efficiency regulation and enhancement of the nerve system of an animal are realized by accurately introducing the high frequency electromagnetic signal into the nerve system of the animal.

The invention discloses a kind of medicine for preventing and curing cerebrovascular dementia. The materials are: ginseng 3-9g, pseudo-ginseng 3-9g, the fruit of Chinese magnoliavine 3-9g, cornus 6-15g, boiled glutinous rehmannia 10-30g, polygonum ultiforun 10-20g, aweto 5-10g fried gutta-percha 10-15g, pilose deer horn 1-3g, leech 1.5-3g, stone calamus 5-10g, polygala root 3-10g, salvia miltiorrhiza 3-15g, tortoise plastron 10-30g. The invention uses the speciality of the Chinese traditional medicine to enhance the oxygen absorbing ability under ordinary pressure and improve the micro-circulation of meninges, enhance the imminity and memory. It not only can cure the cerebrovascular dementia effectively, but also can prevent the disease.

The invention discloses a method and device for enhancing a multi-object tracking capability. The method for enhancing a multi-object tracking capability includes: acquiring brain imaging informationthrough a neural image navigation and positioning system and an imaging device; determining the position of a brain IPS according to the brain imaging information, wherein the IPS is an encephalic region to control brain MOT behaviors; and performing iTBS at the position of the IPS, wherein the iTBS is configured to enhance the excitability of the IPS. The method and device precisely locates the IPS and uses rTMS technology (iTBS) to stimulate the IPS to enhance its excitability and enhance a MOT capability.

The invention relates to a health product formula for solving the problems that an existing formula is single in function and general in effect. The formula comprises the following components in percentage by mass: 48%-52% of Peruvian maca powder, 26%-30% of cordyceps militaris extract, 4%-8% of cinnamon extract, 3%-7% of ginseng extract, 8%-12% of folium ginkgo extract, 0.0003-0.0007% of beta-carotene, 0.01%-0.05% of nicotinamide, 0.1%-0.3% of vitamin C, 0.013%-0.017% of vitamin E, 0.001%-0.003% of vitamin B1, 0.001%-0.003% of vitamin B6, 0.000004%-0.000008% of vitamin B12, 0.08%-0.12% of zinc gluconate and the balance of starch slurry, wherein the sum of all components is 100%. According to the formula, the final formed shape is granule, capsule or tablet; multiple requirements of a human body are considered in the formula; and the effect is good.

The invention discloses a facial palsy rectify patch and a treatment method. The rectify patch consists of medicines and the patches for bearing the medicines. The medicines are made of master medicines and auxiliary medicines. The master medicines comprise the medicines as follows: radix astragali, cassia twig, gambir plant, red peony, salvia miltiorrhiza, szechuan lovage rhizome, kudzuvine root, great burdock achene, earthworm, weeping forsythiae capsule, baical skullcap root, honeysuckle flower, medcinal evodia fruit, zedoary root, turmeric, divaricate saposhnikovia root, magnetite, Bungarus multicinctus, Chinese sage herb, simpleleaf shrub chastetree fruit and paris polyphylla; while the auxiliary medicines comprise one milliliter of laurocapam with a concentration of one percent. The invention can make full use of the Chinese medicine effect and has quick medical effect and obvious efficacy; the medicine is stuck at the joints, channels and collaterals on the surface corresponding to the human body viscera so as to exert a certain positive excitation, so that the nerves can change during the process of energy conversion and information coding; the invention also can activate, enhance, decrease or deactivate some enzymes inside the cell, thereby promoting the body own solution and the recovery ability through the nerves and the internal secretion so as to cure diseases and eliminate symptoms.

A method for decreasing risk of ventricular tachycardia following myocardial infarction increases cell-to-cell coupling and / or excitability in the border zone of an infarcted region of myocardial tissue. Enhanced conduction to treat the border zone is carried out by genetically modifying myocytes in the border zone to form more gap junctions and / or sodium channels and / or calcium channels. Alternatively, enhanced conduction is carried out by incorporating cells into the border zone that form gap junctions with the myocytes and / or form sodium channels and / or form calcium channels.

Methods and devices for treating patients having cardiopulmonary disease such as cardiac arrhythmias, ventricular arrhythmias, pulmonary hypertension, or heart failure comprising a tracheal approach. The method includes ablating a deep cardiac plexus of a patient by advancing an treatment apparatus into a trachea of the patient, extending an ablative energy delivery element of the treatment apparatus through a wall of the trachea at a level of the trachea proximate a tracheal bifurcation, positioning the ablative energy delivery element at a target space between the trachea, an aorta and a pulmonary artery, and ablating, by the ablative energy delivery element, tissue within the target space to substantially disable the deep cardiac plexus.

The invention relates to a granular preparation with a refreshing effect. The granular preparation is prepared from the following ingredients in parts by weight: 15 to 20 parts of erythritol, 70 to 75 parts of isomalt, 3 to 5 parts of paullinia cupana extracts, 2 to 4 parts of Maca extracts, 1 to 5 parts of anhydrous citric acid, 0.5 to 2 parts of radix ginseng extracts and 0.1 to 0.5 part of sucralose. The granular preparation has the advantages that the paullinia cupana extracts, the Maca extracts and the radix ginseng extracts are selected as major active substances, and in addition, the use quantity is reasonably regulated; the refreshing effect of the composition can be effectively enhanced only through the refreshing mechanism complementary principle of the paullinia cupana extracts, the Maca extracts and the radix ginseng extracts; meanwhile, the preparation has the obvious refreshing and antifatigue effects; the sleeping time can be reduced; the excitability is improved.

The invention discloses a preparation method of a feed additive. The preparation method comprises the following steps: a step I, taking walnut green seedcases, crushing the taken walnut green seedcases to obtain walnut green seedcase granules, taking Chinese yam, making the taken Chinese yam into Chinese yam starch paste, taking glycine max, and making the taken glycine max into fermented glycine max; a step II, firstly taking radix astragali, haws, radix angelicae sinensis, momordica cochinchinensis, premna fulva craib, radix isatidis, common andrographis herbs, pollen containing bacillus thuringiensis, poria cocos, folium isatidis, licorice roots, fructus aurantii, pseudo-ginseng, lalang grass rhizomes, mulberry leaves, 10-20 parts of radix bupleuri, radix scutellariae, radix ophiopogonis and lotus seeds, then performing uniform mixing, performing crushing to obtain mixed granules, then taking the walnut green seedcase granules, the Chinese yam starch paste and the fermented glycine max, and uniformly mixing the walnut green seedcase granules with the Chinese yam starch paste, the fermented glycine max and the mixed granules so as to obtain a primary feed additive; a step III, soaking the primary feed additive in tea soup for 24-48h; and a step IV, drying the primary feed additive until the water content is not more than 5% so as to obtain the feed additive.

The invention provides a freckle-removing traditional Chinese medicine composition and an application thereof. The freckle-removing traditional Chinese medicine composition provided by the invention comprises the following components in parts by weight: 1.5 to 2.5 parts of radix angelicae sinensis, 1.5 to 2.5 parts of radix ginseng, 4.5 to 5.5 parts of Babai powder, 1.5 to 2.5 parts of radix astragali seu hedysari, 0.5 to 1.5 parts of radix glycyrrhizae, 1.5 to 2.5 parts of flos rosae rugosae, 0.5 to 1.5 parts of radix salviae miltiorrhizae and 4.5 to 5.5 parts of persimmon leaves. The freckle-removing traditional Chinese medicine composition disclosed by the invention can be used for effectively treating freckles of different ages, different symptoms and different disease courses, and ishigh in recovery rate and remarkable in freckle-removing effect.

The present invention provides a black root Korean ginseng and its preparation process. The black root Korean ginseng has saponin content obviously higher than other red ginseng products. The preparation process of the black root Korean ginseng includes adding astragalus root 20%, root of straight ladybell 20%, acanthopanax bark 20%, ophiopogon root 17%, tuckahoe 16% and dry ginger 7% into solvent; heating and concentrating to obtain concentrated solution; soaking red ginseng in the concentrated solution, and repeated steaming and drying for nine times.

A medical wine for nourishing Yin and invigorating Yang to improve sexual function is prepared from pure rice wine and 15 Chinese-medicinal materials including raspberry fruit, plantain seed, schisandra fruit, dodder seed, etc through pretreating and immersing in pure rice wine in sealed mode for one month. Its advantage is high effect up to 88.04%.

The invention belongs to the technical field for geriatric disease prevention, in particular to a medicine which prevents senile dementia syndrome, and especially prevents vascular dementia effectively without side effects. The invention is characterized in that the medicine is an externally used medical gel and an oral preparation which are prepared from ginkgo leaves, barrenwort, salvia, schisandra chinensis, platyciad semen and camphor (oral administrations are borneol).

The invention discloses a prescription of Chinese traditional medicine oral liquid and a process thereof. The nutritional oral liquid produced by the process is an anti-ageing medicine. The process prescription adopts a pure Chinese medicine preparation and has refined and strict process; experiments prove that the product has no toxic and side effects; and clinical experiments prove that the treating effect is remarkable. The process mainly comprises a production method of soaking for a plurality of days in low alcohol at low temperature, therefore, not only the aim of killing bacteria is achieved, but also active effects in the Chinese traditional medicine is ensured not to lose.