129results about How to "Reduce excitability" patented technology

A method and neurostimulator for providing therapy to a patient is provided. In one technique, electrical background energy is conveyed to a first tissue region of the patient in accordance with stochastic parameter, thereby modulating the excitability of the first tissue region, and electrical stimulation energy is conveyed to the first tissue region when its excitability is modulated. In one example, the stimulation energy may be conveyed to a second tissue region of the patient, thereby therapeutically stimulating the second tissue region. In this case, the excitability of the first tissue region is decreased, thereby reducing any adverse effect that the conveyed stimulation energy has on the first tissue region. As another example, the conveyed stimulation energy stimulates the first tissue region, in which case, the excitability of the first tissue region may be increased, thereby enhancing the stimulation of the first tissue region by the conveyed stimulation energy.

A method and apparatus for stimulation of a baroreflex system of a patient is provided. A method comprises establishing a therapy regimen including at least one pulse which includes at least two phases. Each phase has a polarity which is different than that of the other phase. The baroreflex system of the patient is activated with at least one baroreflex activation device which is responsive to the therapy regimen.

The subject invention is directed to new and useful neurostimulation systems that include an implantable pulse generator dimensioned and configured for implantation in the skull of a patient. The implantable pulse generator has an electrode operatively associated with a distal end portion thereof and can be provided with adjustment means, such as an adjustable biasing member or spring arranged between the electrode to the distal end portion of the pulse generator. The subject invention is also directed to systems involving networked neurostimulators that are configured and adapted to work jointly in accordance with prescribed treatment protocol to effect a desired recovery from brain injury. Such networked neurostimulation systems are particularly advantageous for effecting relatively large and / or relatively distant regions of the brain. The subject invention is further directed to systems and methods for motor-evoked potential (MEP)-based neuromodulation. Further, AC and / or DC stimulation can be utilized, depending on the precise implementation.

An implantable medical device for treating the back of a patient. Stimulation energy is delivered to muscles or joint capsules or ligaments or nerve fibers to improve the heath of the back.

Provided herein are a method and system are provided for the localization of clinically relevant electrophysiological signals necessary for the proper placement of the electrodes for nervous system stimulation. The system provides electrical and mechanical means to stimulate or excite neural structures in order to elicit specific neural responses. The method can include mechanical vibratory stimulation, cutaneous electrical stimulation, electrical stimulation of the peripheral nerves, or photic stimulation, and recording of local field potentials and extracting evoked potentials in response to stimulation. The method also includes extracting components of the evoked potentials that relate the signal in the evoked potentials to specific anatomical structures and localization of the source of the evoked potentials recorded so as to identify the location of the source relative to the recording electrode with high resolution by sampling the evoked potentials with a relative large (macro) electrode that is moved in small incremental steps.

A method of treating a patient with an ailment using an optical element implanted within the patient, comprising conveying low-level laser energy having a wavelength in the range of 600 nm-2500 nm from the optical element to a neuronal element of the patient, thereby modulating the neuronal element to treat the ailment.

Described herein is a system which uses a gene therapy particle that includes at least one gene, cDNA, fragment or analogue of at least one neurotropin that binds to the trkB receptor or the trkB receptor itself. The gene therapy particle is capable of being delivered to a subject in need thereof for therapy of a metabolic disorder. In a particular aspect, this invention is directed to an inventive method that demonstrates a remarkable efficacy on lowering body weight.

Optical flow for a moving platform may be encoded into pulse output. Optical flow contribution induced due to the platform self-motion may be cancelled. The cancellation may be effectuated by (i) encoding the platform motion into pulse output; and (ii) inhibiting pulse generation by neurons configured to encode optical flow component optical flow that occur based on self-motion. The motion encoded may be coupled to the optical flow encoder via one or more connections. Connection propagation delay may be configured during encoder calibration in the absence of obstacles so as to provide system specific delay matrix. The inhibition may be based on a coincident arrival of the motion spiking signal via the calibrated connections to the optical flow encoder neurons. The coincident motion pulse arrival may be utilized in order to implement an addition of two or more vector properties.

The invention discloses a duplex dentin hypersensitivity resistant composition and an application of the composition. The active ingredients of the duplex dentin hypersensitivity resistant composition include a potassium salt and titanium containing bioactive glass, wherein the weight percentage of the potassium salt in the composition is 0.3-12%, and the weight percentage of the titanium containing bioactive glass in the composition is 0.5-15%. The duplex dentin hypersensitivity resistant composition disclosed by the invention can be used for preventing and treating (eliminating or relieving) dentin hypersensitivity; on one side, the potassium salt releases potassium ions to rapidly relieve pain (by reducing the excitability of a dental pulp nerve), on the other side, the bioactive glass can be used for supplementing minerals for a tooth structure to form stable carbonated hydroxyapatite so as to deeply close a dentinal tubule (by improving the permeability of the dentinal tubule); treatment effect is greatly improved, and aching feeling and anaphylaxis can be radically eliminated to achieve the purposes of treating both symptoms and root causes; in addition, as the bioactive glass comprises titanium, the phosphorite layer formed on the surface of a tooth is firmer and more wear-resistant, and the tooth can better resist daily stimulation.

The invention discloses a compound toothpaste with functions of antisepsis, anti-inflammation, acid prevention and desensitization, and a preparation method of the compound toothpaste. The invention adopts natural propolis and traditional Chinese medicine with functions of analgesia, anesthesia and antiallergic effect as main effective preparations, is compounded with the traditional western medicine and is supplemented by biotechnology, so that the compound toothpaste with the functions of antisepsis, anti-inflammation, acid prevention and desensitization can be prepared. The compound toothpaste can be used for preventing and treating periodontitis, dental ulcer, enamel trauma, toothache and sensitivity of teeth, and is also capable of enhancing the self repairing capability of oral cavity tissue, enabling the gum to be healthy, improving the microcirculation, guaranteeing the oral cavity to be healthy and improving the comprehensive antiallergic capability of teeth.

(1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid also known as CPP-115 or its pharmaceutically acceptable salts can be used to treat addiction and neurological disorders such as epilepsy without side effects such as visual field defects caused by vigabatrin (Sabril).

The invention provides a food health product for improving sleep and a preparation method thereof. The food health product is prepared from the following components in parts by weight: 30-50 parts of spine date seed extract, 10-20 parts of broken spore ganoderma lucidum powder, 5-15 parts of gamma-aminobutyric acid powder, 5-10 parts of Indian buead extract, 5-10 parts of thinleaf milkwort root extract, 12-16 parts of lily bulb extract, 1-4 parts of fructus shisandrae extract, 3-6 parts of pearl powder extract, 4-8 parts of oyster shell power, 10-15 parts of magnesium stearate and 0.1-0.5 part of vitamin B6. The invention overcomes the defects in the prior art and provides a health product for improving sleep, and the food health product is simple in formula and reasonable in compatibility of medicines and accords with the principle of syndrome differentiation of traditional Chinese medicine, and the medicines in the formula supplement each other and have obvious effects of improving the sleep.

The invention relates to a method for producing a conversion element (10) for an optical and / or optoelectronic component, wherein the method comprises at least the following steps: a) providing a transparent substrate (1); b) applying a layer (2) that contains powdery glass solder; c) vitrifying the layer (2) by means of a first temperature treatment (TB1), whereby the glass solder (2a) of the layer (2) is vitrified and thus is converted into a transparent glass material (2b) having low natural coloring; d) applying a material containing luminescent substance to the layer (2); and e) performing a second temperature treatment (TB2), whereby the luminescent substance (4) of the material containing luminescent substance sinks into the glass material of the layer (2).

The present invention is directed generally to systems, devices and methods for direct delivery of agents, e.g., pharmaceutical agents, to target spinal and neuronal anatomies, e.g., the dorsal root ganglia (DRG), for the treatment of various disorders, particularly pain and pain related disorders, such as chronic itch, sensory disorders, multiple sclerosis, post-herpetic neuralgia and the like. The system, devices and methods of the invention encompass the agents to be delivered to the target anatomy alone or in combination with electrical stimulation. The delivery device and systems and methods as disclosed herein place the distal end of the delivery element, which comprises at least one agent delivery structure, and optionally at least one electrode, in close proximity, or in contact with or next to the target spinal anatomy, e.g., DRG. A variety of agents can be delivered using the device, including sodium channel blockers, biologics, neuroinflammatory modulators, toxins etc., to selectively neuromodulate the neurons. Agent delivery and / or electrical stimulation can be automated and / or can be controlled automatically or by a pre-determined program, or by a patient control pump (PCA).

(1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid also known as CPP-115 or its pharmaceutically acceptable salts can be used to treat addiction and neurological disorders such as epilepsy without side effects such as visual field defects caused by vigabatrin (Sabril).

The present invention relates to a method for delivering a nucleic acid sequence encoding neuropeptide Y, or a derivative or functional fragment thereof, to a mammalian nervous system target cell. The expression of exogenous NPY, or a derivative or a functional fragment thereof in the target cell(s) provides therapeutic benefit for subjects afflicted with a neurological disorder.

Devices, systems and methods are provided for the targeted treatment of abnormal sensory conditions. In such conditions, physical stimuli is transduced into neuronal impulses that are subsequently transmitted to the central nervous system for processing. Such transduction is achieved by primary sensory neurons in the dorsal root ganglions. Subcellular structures on primary sensory neurons can significantly modulate the function of these neurons, thereby affecting the transduction and reducing the abnormal sensory experiences. Thus, devices, systems and methods are provided for neuromodulating subcellular structures on primary sensory neurons of the dorsal root ganglions.

The invention relates to a movable back type multifunctional massager, belonging to the field of massage and health care appliances. The movable back type multifunctional massager comprises a back massager, an abdomen massager and a manually-controlled touch controller. The back massager comprises four vibratory massage motors, four perceived music massagers, two infrared heaters, two phototherapy luminescent plates, a battery and a controller. The abdomen massager comprises two perceived music massagers, an infrared heater, and a visible light phototherapy luminescent plate. The back massager is used for promoting blood circulation, relieving pains, and achieving the purpose of treating back pains. The abdomen massager is used for treating constipation, and abdominal and gastrointestinal diseases.

The invention relates to a portable far infrared low-voltage electric heating magnet therapy and traditional Chinese medicine physical therapy band. The therapy band mainly comprises a low-voltage power supply battery, a permanent magnet sheet, a high-energy electric heating material which can radiate 4-14 micrometer far infrared rays, and a traditional Chinese medicine dressing bag, wherein the permanent magnet sheet and the high-energy electric heating material are fixedly arranged a girdle which is made of an elastic sports textile fabric, the traditional Chinese medicine dressing bag is detachably arranged on the girdle and the power supply battery is electrically connected with the high-energy electric heating material to supply electric energy to the therapy band. After the therapy band is electrified, heat and far infrared rays can be produced, wherein the far infrared rays can harmoniously resonate with body tissues, the produced heat can heat the traditional Chinese medicine dressing bag to enable liquid medicine in the traditional Chinese medicine dressing bag to be evaporated and guided into a human body, and the permanent magnet sheet can act on the human body through the magnetic field effect and have an effect on micro-current and charge particles in the human body. Therefore, the product provided by the invention has quadruple curative effects, i.e. thermal therapy, magnet therapy, far infrared physical therapy and traditional Chinese medicine fumigation.

The present invention provides compositions comprising hyaluronan with high elasticity, as well as methods for improving joint function, reducing pain associated with joint function and treating osteoarthritis by introducing into a joint a therapeutically effective amount of a composition comprising hyaluronan with high elasticity.

The invention discloses a respiratory training system and method based on bioelectric signals. The respiratory training system comprises a correct respiratory training module, a host control module, a myoelectricity acquisition module and a myoelectricity feedback module, wherein the correct respiratory training module is used for a user to carry out correct respiration essential training with the guidance of a respiration therapist; the host control module is used for receiving the myoelectric signals, carrying out signal processing and pattern recognition, controlling the myoelectricity feedback module to generate feedback stimulation, and meanwhile further controlling the correct respiratory training module to complete cycles of correct respiratory training; the myoelectricity acquisition module is used for recording and acquiring the electric signals of muscles related to respiration muscle groups of the user through electrodes and transmitting the electric signals to the host control module; the myoelectricity feedback module is used for receiving feedback control instructions sent from the host control module and offering related myoelectricity feedback stimulation to the respiration muscle groups of the user through the electrodes. According to the system and the method, the user can be effectively helped to learn, train, master and consolidate a correct respiration method in a biological feedback manner, so that the accuracy and the efficiency of respiratory training are improved.

The invention relates to a pharmaceutical composition for treating children's cough and process for preparation, wherein the main raw materials include belamcanda rhizome, Chinese ephedra, apricot seeds, Indian fieldcress, cicada shell, peucedanum root, batryticated silkworm, roor of sessile stemona, baikal skullcap root through the steps of immersing, boiling, filtering and concentrating.

The present invention relates to a method for delivering a nucleic acid sequence encoding neuropeptide Y, or a derivative or functional fragment thereof, to a mammalian nervous system target cell. The expression of exogenous NPY, or a derivative or a functional fragment thereof in the target cell(s) provides therapeutic benefit for subjects afflicted with a neurological disorder.

The invention relates to a multifunctional far-infrared intelligent clothes caring machine and a control method of the multifunctional far-infrared intelligent clothes caring machine. The caring machine comprises a box body (1) and a sliding door (2) installed on the box body (1), a supporting plate (101) is vertically installed at the position, close to a back plate, in the box body (1) and connected between a left side plate and a right side plate of the box body (1), and an air channel is formed between the supporting plate (101) and the back plate of the box body (1); a steam dissipating hole (106) and an air inlet hole (107) are formed in the box body (1), an air outlet fan (108) is installed in the steam dissipating hole (106), a filter is installed in the air inlet hole (107), and a far-infrared generator (102) is installed on one face, facing the back plate of the box body (1), of the supporting plate (101). According to the multifunctional far-infrared intelligent clothes caring machine and the control method of the multifunctional far-infrared intelligent clothes caring machine, the clothes caring machine is convenient to use and has multiple functions.

The invention discloses a high-efficiency magnetic medicament waist belt for treating acute and chronic soft tissue injury, hyperosteogeny and neck shoulder pain or lumbocrural pain of orthopedics and traumatology and a preparation method thereof. The waist belt comprises three parts, namely a waist belt main body, a magnetic sheet and a medicament patch, wherein the medicament patch comprises the following raw material medicaments: orientvine, kadsura pepper stem, Chinese starjasmine stem, suberect spatholobus stem, Japanese honeysuckle stem, common monkshood mother root, kusnezoff monkshood root, nux vomica, dahurian angelica root, drynaria rhizome, safflower, trogopterus dung, ground beeltle, himalayan teasel root, cassia bark and the like. The high-efficiency magnetic medicament waist belt of the invention is worn on the waist of a patient to treat various acute and chronic lumbocrural pain with good treatment effect based on the treatment principle of the magnetic medicament. The magnetic medicament waist belt has the function of treating both symptoms and root causes of the lumbocrural pain caused by various symptoms. The magnetic medicament waist belt has the advantages of simple and convenient method, short treatment period, no surgery, no pain, low medical expense and safe and reliable treatment when used for treating the diseases such as acute and chronic soft tissue injury, hyperosteogeny, neck shoulder pain or lumbocrural pain of orthopedics and traumatology and the like.

A method and neurostimulator for providing therapy to a patient is provided. In one technique, electrical background energy is conveyed to a first tissue region of the patient in accordance with stochastic parameter, thereby modulating the excitability of the first tissue region, and electrical stimulation energy is conveyed to the first tissue region when its excitability is modulated. In one example, the stimulation energy may be conveyed to a second tissue region of the patient, thereby therapeutically stimulating the second tissue region. In this case, the excitability of the first tissue region is decreased, thereby reducing any adverse effect that the conveyed stimulation energy has on the first tissue region. As another example, the conveyed stimulation energy stimulates the first tissue region, in which case, the excitability of the first tissue region may be increased, thereby enhancing the stimulation of the first tissue region by the conveyed stimulation energy.

An application of L-serine in preparing the slow-release or release controllable medicines in the form of solid, liquid, or spray for treating cerebral ischemia is disclosed.

The invention provides milk powder for improving the sleep quality of children. The milk powder aims at the nutritional requirements of children of 3-15 years old in the growth process, provides proteins, vitamins, taurine, calcium, iron, zinc and soluble dietary fibers with reasonable content required by growth of the children, facilitates healthy growth of the children, promotes height growth ofthe children, has strong milk fragrance and unique fragrance of jujubes and spina date seeds, and is good in taste, good in reconstituability and easy to absorb. Meanwhile, the milk powder provided by the invention contains spina date seed powder, jujube powder and Chinese yam powder which interact with one another, so that the excitability of nervous systems of children is reduced by comprehensively conditioning organs such as heart, brain, liver, spleen and stomach, and the effects of synergistically calming, soothing the nerves and helping sleep are achieved. According to the milk powder provided by the invention, through the combined action of all the components, children can be helped to quickly sleep, the deep sleep time is prolonged, the deep sleep continuity is ensured, the wakingfrequency in the sleep process is reduced, and the sleep quality of children is effectively improved.

The invention relates an animal feed and particularly relates to a laying hen feed. The laying hen feed is composed of following raw materials in parts by weight: 100-120 parts of wheat bran, 80-100 parts of bean cakes, 50-70 parts of cottonseed meal, 50-60 parts of fish meal, 10-20 parts of eggshell meal, 10-20 parts of bone meal, 3-6 parts of shell powder, 2-5 parts of table salt, 0.1-0.3 part of aureomycin formate, 0.5-0.8 part of phytase, 0.6-0.8 part of choline chloride and 0.01-0.05 part of gypsum powder and garlic essential oil.

The invention relates to home bedclothes, and particularly relates to a compound multifunctional health-care mattess structure. The mattess structure provided by the invention is realized through the following technical scheme: the compound multifunctional health protection mattess structure comprises a baseplate and a latex rubber foam layer which covers the baseplate and is provided with a magnetic stripe, the latex rubber foam layer is provided with an air hole I and multiple rows of inserting holes; the upper surface of the baseplate is provided with pressing pillars which correspond to the inserting holes one to one and are in inserted connection with the inserting holes, and the upper surface of the baseplate is also provided with support pillars the height of which are lower than that of the pressing pillars. Moisture, humidity and sweat on the baseplate of the mattess structure can be spread away easily, and air permeability of the mattess structure is better compared with that of the background technology.