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Application of dracocephalum moldavica L. general flavone in preparing medicament for preventing and treating cerebrovascular disease

A technology of cerebrovascular disease and total flavonoids, which is applied in the field of medicine, can solve the problems reported in the literature (Abulimiti, Aileti, Mukhtar, etc.) to prevent or improve brain damage and is cheap Effect

Inactive Publication Date: 2011-08-03
孙雅煊 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that the total flavonoids of sweet green orchid have pharmacological effects such as anti-oxidation, anti-myocardial ischemia, blood lipid lowering, liver protection, anti-inflammation, anti-virus, antibacterial, etc., but there is no literature report on the prevention and treatment of cerebrovascular diseases by the total flavonoids of sweet green orchid (Abulimiti, Ailati, Mukhtar, et al. Research on flavonoids in Xiangqinglan [J]. Food Science, 2007, 28(8): 384-386; Zhang Li, He Jinhua, Wang Xintang.Purification and content determination of total flavonoids in Xiangqinglan[J].Xinjiang Traditional Chinese Medicine, 2009,27(2):67-69; ]. Chinese patent medicine, 2003, 25 (2): 154-156; Wei Gaiqin, Xing Jianguo, He Chenghui, et al. Study on the separation and purification of luteolin in sweet green orchid with HPD100 macroporous adsorption resin [J]. Chinese patent medicine, 2008, 30(11): 1608-1611; Lou Hongxiang, Ren Dongmei, Wang Yajun. An extract of total flavonoids from Cymbidium orchid and its preparation method and application [P]. Publication number: CN101537039)

Method used

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  • Application of dracocephalum moldavica L. general flavone in preparing medicament for preventing and treating cerebrovascular disease
  • Application of dracocephalum moldavica L. general flavone in preparing medicament for preventing and treating cerebrovascular disease
  • Application of dracocephalum moldavica L. general flavone in preparing medicament for preventing and treating cerebrovascular disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1 Study on the anti-cerebral thrombosis of total flavonoids of vanilla

[0016] 1. Materials and methods

[0017] 1.1 Experimental animals: healthy adult male Wistar rats, SPF / VAF grade, weighing 250-300 g, provided by Beijing Weitong Lihua Laboratory Animal Technology Co., Ltd., license number: SCXK (Beijing) 2007-0001. Before the experiment, they were acclimated to the environment for a week in the SPF laboratory animal room of the Applied Arts and Sciences Health Food Functional Testing Center of Beijing Union University.

[0018] 1.2 Reagents: total flavonoids of Xiangqinglan: provided by Xinjiang Uygur Autonomous Region Institute of Materia Medica; Naoxintong Capsule: Xianyang Buchang Pharmaceutical Co., Ltd.

[0019] 1.3 Instrument: AR-2140 1 / 10,000 electronic balance: METTLER TOLEDO Instruments Co., Ltd.

[0020] 1.4 Grouping and administration of experimental animals

[0021] Male Wistar rats were taken and randomly divided into 5 groups: model group,...

Embodiment 2

[0032] Example 2 Study on the anti-cerebral ischemia of total flavonoids of indigo orchid

[0033] 1. Materials and methods

[0034] 1.1 Experimental animals: healthy adult male Wistar rats, SPF / VAF grade, weighing 250-300 g, provided by Beijing Weitong Lihua Laboratory Animal Technology Co., Ltd., license number: SCXK (Beijing) 2007-0001. Before the experiment, they were acclimated to the environment for a week in the SPF laboratory animal room of the Applied Arts and Sciences Health Food Functional Testing Center of Beijing Union University.

[0035] 1.2 Reagents: total flavonoids of Xiangqinglan: provided by Xinjiang Uygur Autonomous Region Institute of Materia Medica; Naoxintong Capsule: Xianyang Buchang Pharmaceutical Co., Ltd.; Chloral Hydrate: Tianjin Guangfu Institute of Fine Chemicals; Red tetrazolium: Sigma Company; MDA , MPO, SOD, Coomassie brilliant blue kit: Nanjing Jiancheng Bioengineering Institute.

[0036] 1.3 Instruments: AR-2140 1 / 10,000 electronic balance...

Embodiment 3

[0060] As shown in Table 3, the total flavonoids of vanilla can significantly inhibit the decreasing trend of SOD activity in brain tissue of rats after ischemia-reperfusion, and at the same time, can effectively reduce MPO activity and MDA content, indicating that it exerts anti-brain effects through anti-inflammatory and anti-oxidation. ischemic effect. Example 3 Study on the anti-cerebral hypoxia of total flavonoids of vanilla

[0061] 1. Materials and methods

[0062] 1.1 Experimental animals: healthy adult male ICR mice, SPF / VAF grade, weighing 18-22 g, provided by Beijing Weitong Lihua Laboratory Animal Technology Co., Ltd., license number: SCXK (Beijing) 2007-0001. Before the experiment, they were acclimated to the environment for a week in the SPF laboratory animal room of the Applied Arts and Sciences Health Food Functional Testing Center of Beijing Union University.

[0063] 1.2 Reagents: total flavonoids of Xiangqinglan: provided by Xinjiang Uygur Autonomous Regio...

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Abstract

The invention belongs to the technical field of medicine, and provides application of dracocephalum moldavica L. general flavone in preparing a medicament for preventing and treating cerebrovascular disease. Proven by pharmacological experiments, the dracocephalum moldavica L. general flavone has the effects on resisting cerebralthrombosis, resisting cerebral ischemia, resisting cerebral anoxia, resisting vascular dementia and the like. The dracocephalum moldavica L. general flavone has notable effects on preventing and treating cerebrovascular disease and is hopeful to become a medicament for preventing and treating cerebrovascular disease.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of total flavonoids of vanilla in the preparation of drugs for preventing or treating cerebrovascular diseases, in particular to the preparation of total flavonoids from vanilla in the preparation of preventing or treating cerebral thrombosis, cerebral ischemia, cerebral hypoxia or cerebrovascular disease. Application of vascular dementia disease drugs. Background technique [0002] Cerebrovascular disease refers to brain dysfunction caused by various vascular brain lesions. It constitutes the three major causes of human death together with heart disease and cancer. Cerebrovascular disease has a high prevalence, high mortality, high disability rate, and high recurrence rate. Among them, 50% to 70% of the surviving patients are left with severe disabilities, and they need to be cared for in their lives, causing a heavy burden to society and their famil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61P9/10A61P7/02A61P25/08
Inventor 孙雅煊刘婷郑秋生
Owner 孙雅煊
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