Application of lutein in preparation of medicaments for preventing and treating cerebral vascular diseases

A cerebrovascular disease and lutein technology, applied in the field of medicine, can solve problems such as the prevention and treatment of cerebrovascular diseases that have not been found with lutein, and achieve the effect of preventing or improving brain damage without toxic and side effects

Inactive Publication Date: 2011-10-12
北京联合大学应用文理学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there is no report in the existing literature that lutein is used for the prevention and treatment of cerebrovascular diseases

Method used

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  • Application of lutein in preparation of medicaments for preventing and treating cerebral vascular diseases
  • Application of lutein in preparation of medicaments for preventing and treating cerebral vascular diseases
  • Application of lutein in preparation of medicaments for preventing and treating cerebral vascular diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1 Effect of Lutein on Cerebral Ischemia-Reperfusion

[0016] 1 Materials and methods

[0017] 1.1 Materials

[0018] 1.1.1 Experimental animals

[0019] Male ICR mice, clean grade, weighing 25-28 g, Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., license number: SCXK (Beijing) 2007-001.

[0020] 1.1.2 Drugs and reagents

[0021] Lutein (purity ≥ 90%, Tianjin Jianfeng Natural Products Research and Development Co., Ltd.): School of Biochemical Engineering, Beijing Union University; red tetrazolium (2,3,5-triphenyltetrazolium chloride, TTC), Beijing Baierdi Biotechnology Co., Ltd.; malondialdehyde (MDA), carbonyl, Coomassie Brilliant Blue kits, Nanjing Jiancheng Institute of Bioengineering; other reagents are domestic analytical grade.

[0022] 1.1.3 Experimental Instruments

[0023] Water bath: Beijing Changfeng Instrument Co., Ltd.; multifunctional microplate reader: Sigma Company; TGL 16M centrifuge: Hunan Kaida Scientific Instrument Co., Lt...

Embodiment 2

[0048] Example 2 Effect of Lutein on Cerebral Hemorrhage

[0049] 1 Materials and methods

[0050] 1.1 Materials

[0051] 1.1.1 Experimental animals

[0052] Male SD rats, clean grade, weighing 200-240 g, Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., license number: SCXK (Beijing) 2007-001.

[0053] 1.1.2 Drugs and reagents

[0054] Lutein (purity ≥ 90%): Tianjin Jianfeng Natural Products Research and Development Co., Ltd.; collagenase type VII, Sigma Company; malondialdehyde (MDA), superoxide dismutase (SOD), lactate dehydrogenase (LDH) , Coomassie Brilliant Blue kit, Nanjing Jiancheng Bioengineering Institute; other reagents are domestic analytical grade.

[0055] 1.1.3 Experimental Instruments

[0056] Brain stereotaxic instrument: Shenzhen Ruiwode Life Science and Technology Co., Ltd.; micro-injector (Shanghai Anting micro-sampler factory); water bath: Beijing Changfeng Instrument Co., Ltd.; multi-functional microplate reader: Sigma Company; TGL 16M ...

Embodiment 3

[0081] Example 3 Effect of Lutein on Cerebral Hypoxia

[0082] 1 Materials and methods

[0083] 1.1 Materials

[0084] 1.1.1 Experimental animals

[0085] Male ICR mice, clean grade, weighing 25-28 g, Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., license number: SCXK (Beijing) 2007-001.

[0086] 1.1.2 Drugs and reagents

[0087] Lutein (purity ≥ 90%, Tianjin Jianfeng Natural Products Research and Development Co., Ltd.): School of Biochemical Engineering, Beijing Union University; sodium nitrite, Xi'an Chemical Reagent Factory.

[0088] 1.1.3 Experimental Instruments

[0089] AR-2140 1 / 10,000 electronic balance: Mettler-Toledo Instrument Co., Ltd.

[0090] 1.2 Method

[0091] 1.2.1 Grouping and administration of animals

[0092] The mice were randomly divided into 5 groups, namely the sham operation group, the model group and the lutein high, medium and low dose (30, 15, 7.5 mg / kg) groups. The drug was dissolved in vegetable oil before use, and adminis...

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Abstract

The invention discloses application of lutein in preparation of medicaments for preventing and treating cerebral vascular diseases. The lutein can be extracted by using a plurality of methods, is wide in source and high in safety. Pharmacodynamic studies show that the lutein can be applied to preventing and treating cerebral ischemia, cerebral hemorrhage, cerebral anoxia and vascular dementia, and other cerebral vascular diseases.

Description

technical field [0001] The invention relates to a new medical application of lutein, in particular to the application of lutein in drugs for preventing or treating cerebrovascular diseases, and belongs to the technical field of medicine. Background technique [0002] Cerebrovascular disease is one of the three major causes of death and the first cause of disability in adults, and it is also one of the important causes of senile dementia and psychological disorders. With the progress of society, the improvement of living standards and the aging population, the onset of cerebrovascular diseases is becoming younger and younger. There are about 2 million new patients in the country every year, and about 1.5 million patients die of cerebrovascular diseases, which seriously threatens human health and life safety. . Therefore, it is of great significance to develop drugs for the prevention and treatment of cerebrovascular diseases. [0003] Lutein, also known as lutein, is an oxy...

Claims

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Application Information

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IPC IPC(8): A61K31/047A61P9/10
Inventor 孙雅煊惠柏棣刘婷戴雪伶高兆兰张静王振华郑秋生姜招峰
Owner 北京联合大学应用文理学院
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