Use of butenolide I in preparing drugs for controlling immunological liver injury

A technology of Atractylodes lactone and liver injury, applied in the field of medicine, can solve the problem of lack of specific drugs for the clinical treatment of immune liver injury, and achieve good development prospects, convenient preparation, and low price

Inactive Publication Date: 2011-10-19
SHAANXI INST FOR FOOD & DRUG CONTROL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] my country is one of the countries with the highest incidence of viral hepatitis B. According to statistics, there are about 93 million hepatitis B virus carriers in my country, and one-third of them have clinical manifestations of liver damage, and there is still a lack of clinical treatment for immune liver damage. specific drugs

Method used

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  • Use of butenolide I in preparing drugs for controlling immunological liver injury
  • Use of butenolide I in preparing drugs for controlling immunological liver injury
  • Use of butenolide I in preparing drugs for controlling immunological liver injury

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Experimental program
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Embodiment Construction

[0021] Combined with Atractylodes lactone I on the liver index, spleen index, and liver histopathological changes in mice with immune liver injury caused by BCG combined with LPS, and on the production of MDA in liver homogenate and the level of GSH-px and TNF- The levels of α, NO and iNOS will further describe the present invention in detail, which is an explanation rather than a limitation of the present invention.

[0022] 1. Establishment and grouping of mouse models of immune liver injury induced by BCG combined with LPS

[0023] 1.1 Source of mice

[0024] Kunming mice, male, weighing 22-24 g, were supplied by the Experimental Animal Center of Xi'an Jiaotong University. In an environment with a constant temperature and a light cycle of 12h:12h, the immune liver injury model was established after feeding for 1wk. Before that, they were fasted for 24h and drank water arbitrarily.

[0025] 1.2 Sources of reagents and medicines

[0026] Atractylodes macrolide I was extrac...

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Abstract

The invention discloses a use of butenolide I for preparing drugs for controlling immunological liver injury. With the present invention, the butenolide I can reduce levels of TNF-alpha and NO, wherein the TNF-alpha and the NO play important roles in a pathogenic process of the immunological liver injury; the butenolide I can reduce elevated levels of the NO and the iNOS in liver homogenates of immunological liver injury mice so as to decrease the liver injury induced by the NO; the butenolide I can inhibit a overexpression of the TNF-alpha so as to decrease the direct liver injury or the indirect liver injury induced by the TNF-alpha. In addition, the use of the butenolide I as the drug for controlling the immunological liver injury has advantages of convenient preparation, extensive sources, low price and high safety, and has good development and application prospect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to the new application of the lactone compound atractylodes lactone I, in particular to the application of the atractylodes lactone I in the prevention and treatment of immune liver injury. Background technique [0002] Atractylodes macrocephala is the dry rhizome of Atractylodes macrocephala Koidz., which has the functions of invigorating the spleen and replenishing qi, drying dampness and promoting diuresis, antiperspirant, and preventing miscarriage. Edema, spontaneous sweating, fetal restlessness, etc. (Chinese Pharmacopoeia Commission. Chinese Pharmacopoeia Part One. Beijing: China Medical Science and Technology Press, 2010, [S]: 95-96.). Modern pharmacological studies have shown that Atractylodes macrocephala has multiple effects such as diuresis, anti-tumor, anti-inflammation, anti-diabetes, and anti-aging. [0003] Atractylodes lactone I is the main active ingredient of Atra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61P1/16A61P37/02
Inventor 王嫦鹤杨智海张秉华王发刘芳李继焦洁宋莉
Owner SHAANXI INST FOR FOOD & DRUG CONTROL
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