The invention relates to a compound immunity-enhancing nutritional food formula and a preparation method thereof, and belongs to the field of nutritional food. The compound immunity-enhancing nutritional food formula comprises sodium alginate, pachyman, coix seed extract, codonopsispilosula, ginsenoside, astragalus polysaccharide, polygonatum, honeysuckle, dandelion, gardenia, peach kernel, saffron, polygonatum, angelica, mulberry brass, yam polysaccharide, endothelium corneumgigeriaegalli, hawthorn flavone, flower substitute, perilla, medlar polysaccharide, sea buckthorn, papaya ferment, dendrobiumofficinale, protein peptide, ossein peptide, arabinose, xylitol and whey protein. The invention has the advantages of tonifying qi and blood, enhancing immunity, invigorating spleen, improving appetite, tranquilizing mind, eliminating toxin in vivo, restoring normal metabolism of a human body, eliminating excessive free radicals, comprehensively supplementing nutrition of the human body, activating phagocytosis of immune cells of the human body, strengthening physique, promoting qi and blood movement, improving sleep, increasing appetite, increasing blood oxygen content, improving immunecell index, reducing diseases and increasing rehabilitation rate.