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Process for refining isosorbide mononitrate

A technology of isosorbide dinitrate and a composition, applied in the field of medicine, can solve the problems of slow onset, large toxic and side effects, easy rebound and the like, and achieves the effects of being unsuitable for recurrence, low in price, and reducing toxic and side effects

Inactive Publication Date: 2015-10-21
仁和堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its purpose is to solve the problem of treating angina pectoris, overcoming the slow onset of effect of western medicine isosorbide mononitrate, easy to rebound, and large toxic and side effects, so as to achieve the goal of treating both symptoms and root causes

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A compound isosorbide mononitrate pharmaceutical composition is characterized in that it is prepared from the following weight ratio raw materials,

[0036] 1 part of isosorbide mononitrate, 50 parts of kudzu root, 50 parts of corydalis, 50 parts of red peony root, 45 parts of salvia miltiorrhiza, 45 parts of sumac, 45 parts of notoginseng, 40 parts of chuanxiong, 40 parts of Cyperus cyperi, 40 parts of cinnamon, 40 parts of polygala 35 parts of Dandelion, 35 parts of Achyranthes bidentata, 35 parts of Shichangpu, 30 parts of Poria cocos, 30 parts of Moutan bark, 30 parts of lily, 25 parts of epimedium, 25 parts of ginger, and 20 parts of Schisandra.

[0037] Wherein said isosorbide mononitrate can be purchased commercially, and preferred preparation method is:

[0038] 1 In a 100 mL dry three-necked flask, add acetic acid (3.6 g, 60 mmol) and acetic anhydride (6.12 g, 60 mmol), and keep the internal temperature of the reaction at -5±1 °C, start adding concentrated nitr...

Embodiment 2

[0050] functional experiment

[0051] Anti-hypoxia experiment

[0052] 1. Animals:

[0053] Test animals: healthy mice 20-25g

[0054] 2. Drugs and reagents:

[0055] Test drug, the drug prepared in Example 1; positive control drug: propranolol, provided by Tianjin Lisheng Pharmaceutical Co., Ltd.; isoproterenol hydrochloride, provided by Shanghai Hefeng Pharmaceutical Co., Ltd.

[0056] 3. Experimental method:

[0057] 80 mice were randomly divided into 4 groups, 20 in each group. The normal group and the model group were given normal saline, the experimental group was given the pharmaceutical composition prepared in the embodiment, and the positive control group was given propranolol 20mg / kg. After gavage for 1 hour, the normal group was subcutaneously injected with equal volume of normal saline, and the other groups were subcutaneously injected with isoproterenol hydrochloride 20 mg / kg. After 15 minutes, they were put into a 250 mL jar containing 15 g of soda lime, and ...

Embodiment 3

[0066] clinical experiments

[0067] Select 90 patients with coronary heart disease and angina pectoris and divide them into two groups randomly. The treatment group consisted of 45 cases, including 21 males and 24 females, aged 51 to 72 years, with an average of 60.37 years, and the course of disease was half a year to 10 years. There were 45 cases in the control group, 22 males and 23 females, aged 50-72 years, with an average age of 59.87 years, and the course of disease was 5 months to 11 years. There was no significant difference in gender, age, and course of disease between the two groups before treatment (P> 0.05), which are comparable.

[0068] Diagnostic criteria

[0069] Western medicine diagnostic criteria

[0070] Refer to "Suggestions for the Diagnosis and Treatment of Unstable Angina Pectoris" by the Cardiovascular Disease Branch of the Chinese Medical Association.

[0071] Diagnosis and Syndrome Differentiation Standards of TCM

[0072] The TCM syndrome dif...

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Abstract

The invention relates to a process for refining isosorbide mononitrate. The refined isosorbide mononitrate is used for preparing compound medicine for angina. The medicine comprises 1 part of isosorbide mononitrate, 50 parts of radix pueraiae, 50 parts of corydalis yanhusuo, 50 parts of red peony roots, 45 parts of salviae miltiorrhizae, 45 parts of sappan caesalpinia, 45 parts of panax notoginseng, 40 parts of ligusticum wallichii, 40 parts of rhizoma cyperi, 40 parts of cinnamon, 40 parts of polygala amflra, 35 parts of dandelion, 35 parts of achyranthes bidentata, 35 parts of rhizoma acori talarinowii, 30 parts of poria cocos, 30 parts of moutan bark, 30 parts of lily, 25 parts of epimedium herbs, 25 parts of fresh ginger and 25 parts of Chinese magnoliavine fruits. The compound isosorbide mononitrate medicine composition can comprehensively treat the angina, is small in side effect, low in price and easy and convenient to make and has broad application prospects.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a Chinese and western medicine preparation for treating angina pectoris, in particular to the application of a compound medicine made of western medicine isosorbide mononitrate and Chinese herbal medicine in treating angina pectoris. Background technique [0002] In the field of clinical medicine today, cardiovascular system diseases have always been one of the diseases most likely to cause human death, and coronary heart disease and angina pectoris are the most common frequently-occurring diseases in cardiovascular system diseases. Angina pectoris is a clinical symptom caused by acute and temporary ischemia and hypoxia of the myocardium. Most of the patients are middle-aged and elderly people. It often occurs when some inducement exists. It is characterized by paroxysmal chest compression or The pain sensation is mainly located at the back of the sternum, and can ...

Claims

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Application Information

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IPC IPC(8): A61K36/9068C07D493/04A61P9/10
Inventor 林凡儒姚其胜许莹赵树楷李宁薛颖高聪杰
Owner 仁和堂药业有限公司
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