Process for refining isosorbide mononitrate
A technology of isosorbide dinitrate and a composition, applied in the field of medicine, can solve the problems of slow onset, large toxic and side effects, easy rebound and the like, and achieves the effects of being unsuitable for recurrence, low in price, and reducing toxic and side effects
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Embodiment 1
[0035] A compound isosorbide mononitrate pharmaceutical composition is characterized in that it is prepared from the following weight ratio raw materials,
[0036] 1 part of isosorbide mononitrate, 50 parts of kudzu root, 50 parts of corydalis, 50 parts of red peony root, 45 parts of salvia miltiorrhiza, 45 parts of sumac, 45 parts of notoginseng, 40 parts of chuanxiong, 40 parts of Cyperus cyperi, 40 parts of cinnamon, 40 parts of polygala 35 parts of Dandelion, 35 parts of Achyranthes bidentata, 35 parts of Shichangpu, 30 parts of Poria cocos, 30 parts of Moutan bark, 30 parts of lily, 25 parts of epimedium, 25 parts of ginger, and 20 parts of Schisandra.
[0037] Wherein said isosorbide mononitrate can be purchased commercially, and preferred preparation method is:
[0038] 1 In a 100 mL dry three-necked flask, add acetic acid (3.6 g, 60 mmol) and acetic anhydride (6.12 g, 60 mmol), and keep the internal temperature of the reaction at -5±1 °C, start adding concentrated nitr...
Embodiment 2
[0050] functional experiment
[0051] Anti-hypoxia experiment
[0052] 1. Animals:
[0053] Test animals: healthy mice 20-25g
[0054] 2. Drugs and reagents:
[0055] Test drug, the drug prepared in Example 1; positive control drug: propranolol, provided by Tianjin Lisheng Pharmaceutical Co., Ltd.; isoproterenol hydrochloride, provided by Shanghai Hefeng Pharmaceutical Co., Ltd.
[0056] 3. Experimental method:
[0057] 80 mice were randomly divided into 4 groups, 20 in each group. The normal group and the model group were given normal saline, the experimental group was given the pharmaceutical composition prepared in the embodiment, and the positive control group was given propranolol 20mg / kg. After gavage for 1 hour, the normal group was subcutaneously injected with equal volume of normal saline, and the other groups were subcutaneously injected with isoproterenol hydrochloride 20 mg / kg. After 15 minutes, they were put into a 250 mL jar containing 15 g of soda lime, and ...
Embodiment 3
[0066] clinical experiments
[0067] Select 90 patients with coronary heart disease and angina pectoris and divide them into two groups randomly. The treatment group consisted of 45 cases, including 21 males and 24 females, aged 51 to 72 years, with an average of 60.37 years, and the course of disease was half a year to 10 years. There were 45 cases in the control group, 22 males and 23 females, aged 50-72 years, with an average age of 59.87 years, and the course of disease was 5 months to 11 years. There was no significant difference in gender, age, and course of disease between the two groups before treatment (P> 0.05), which are comparable.
[0068] Diagnostic criteria
[0069] Western medicine diagnostic criteria
[0070] Refer to "Suggestions for the Diagnosis and Treatment of Unstable Angina Pectoris" by the Cardiovascular Disease Branch of the Chinese Medical Association.
[0071] Diagnosis and Syndrome Differentiation Standards of TCM
[0072] The TCM syndrome dif...
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Abstract
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