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Drug for curing coronary disease and method for preparing the same

A technology for coronary heart disease and medicine, applied in the field of Guanxinbao soft capsule and its preparation, to achieve the effects of scavenging free radicals, reducing sudden death rate and high safety

Active Publication Date: 2008-01-30
TIANNIAN PHARMA HARBIN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, traditional Chinese medicines such as styrax and borneol, which are effective in treating coronary heart disease and angina pectoris, are also used in other prescriptions (such as Guanxin Suhe pills, etc.). Western medicine compound preparations treat and prevent coronary heart disease and angina pectoris, and are used in acute attacks of coronary heart disease and angina pectoris. There have been no reports at home and abroad.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Preparation method of the present invention

[0024] a. Weigh 50 grams of borneol, crush the borneol, pass through a 100-mesh sieve, and heat it together with 50 grams of insect wax at a low temperature of 40°C to make a solid dispersion system to change the solubility of borneol and prevent the precipitation of borneol. Take 100 grams of Styrax, finely Mix 245 grams of fish oil and 5 grams of vitamin E evenly, then add dispersed borneol, mix and stir evenly.

[0025] b. Mix 425g of gelatin, 425g of glycerin and 150g of water evenly in a certain proportion, heat at 60°C to make the capsule material of the soft capsule, keep warm and degas for 30 minutes, and set aside.

[0026] c. Pour the prepared medicinal solution into the material liquid hopper of the soft capsule pill press machine, inject the glue solution of the capsule material into the glue solution hopper, adjust the spray body so that the content reaches 0.45g / capsule for pilling.

Embodiment 2

[0028] a. Weigh 50 grams of borneol, crush the borneol, pass through a 100-mesh sieve, and heat it together with 25 grams of insect wax at a low temperature of 45°C to make a solid dispersion system to change the solubility of borneol and prevent the precipitation of borneol; take 150 grams of Styrax, finely Mix 245 grams of fish oil and 5 grams of vitamin E evenly, then add dispersed borneol, mix and stir evenly.

[0029] b. Mix 425g of gelatin, 425g of glycerin, and 150g of water evenly in a certain proportion, heat at 60°C to make the capsule material of the soft capsule, keep warm and degas for 35 minutes, and set aside.

[0030] c. Pour the prepared medicinal solution into the material liquid hopper of the soft capsule pill press machine, inject the glue solution of the capsule material into the glue solution hopper, adjust the spray body so that the content reaches 0.45g / capsule for pilling.

Embodiment 3

[0032] a. Weigh 50 grams of borneol, crush the borneol, pass through a 100-mesh sieve, and heat it together with 25 grams of insect wax at a low temperature of 50°C to make a solid dispersion system to change the solubility of borneol and prevent the precipitation of borneol; take 200 grams of Styrax, finely Mix 245 grams of fish oil and 5 grams of vitamin E evenly, then add dispersed borneol, mix and stir evenly.

[0033] b. Mix 425g of gelatin, 425g of glycerin, and 150g of water evenly in a certain proportion, heat at 65°C to make the capsule material of the soft capsule, keep warm and degas for 30 minutes, and set aside.

[0034] c. Pour the prepared medicinal solution into the material liquid hopper of the soft capsule pill press machine, inject the glue solution of the capsule material into the glue solution hopper, adjust the spray body so that the content reaches 0.45g / capsule for pilling.

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Abstract

The present invention relates to a drug to treat coronary artery disease and the preparation method, borneol is weighed, smashed and passed through 100 mesh screen, then the borneol is heated at 40 DEG C to 65 DEG C along with the Chinese insect wax to be made into a solid dispersion system, so as to change the solubility of the borneol and prevent the precipitation of the borneol; the storax, refined fish oil and vitamin E are weighted in proportion and are mixed evenly, then the borneol after the dispersing process is added, mixed and agitated evenly, after that, gelatin, glycerin, and water are mixed evenly in proportion, heating at 60 DEG C to 70 DEG C to prepare the capsule material of the soft capsule, then the thermal insulation and degassing are carried out for 15 to 45 minutes. The invention takes the storax, borneol, refined fish oil and vitamin E as the raw materials, the soft capsule preparation which is made by compression can remove the obstruction, regulating qi-flowing for relieving pain, which is used for chest blockage, chest tightness and pains caused by qi stagnation and blood stasis, heart vessels obstruction; as well as the coronary heart disease and angina with the symptoms thereof. The drug combines the functions of first aid, prevention and treatment, which can also overcome the shortcomings of other types of drugs.

Description

technical field [0001] The invention relates to a Chinese patent medicine, in particular to a Guanxinbao Soft Capsule which has first-aid, long-term treatment and prevention effects on coronary heart disease and angina pectoris and a preparation method thereof. Background technique [0002] The three major diseases that threaten mankind today are cardiovascular disease, cerebrovascular disease and cancer, and coronary heart disease is recognized as the number one killer of human beings in the world. According to the data released by WHO, as many as 18 million patients die from coronary heart disease every year, accounting for 1 / 4 of the annual death toll in the world. The rate ranks first in the world at 53.6%; Japan is the lowest at 4.1%. According to the statistical data of 5 million people in 16 provinces and cities in my country since 1993, the mortality rate of coronary heart disease is 22.6%, which is lower than the international level, and the average prevalence rate...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K9/48A61K47/42A61P9/10A61K31/045A61K31/355A61K35/60
Inventor 柳志强
Owner TIANNIAN PHARMA HARBIN
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