Traditional Chinese medicine compound preparation for preventing and treating climacteric syndrome and preparation method of traditional Chinese medicine compound preparation

A perimenopausal and compound preparation technology, which is applied in the direction of medical formula, medical preparations containing active ingredients, drug delivery, etc., can solve the lack of prevention and treatment of perimenopausal syndrome and other problems

Inactive Publication Date: 2019-12-17
GANSU UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, clinically, there is still a lack of effective traditional Chinese medicine compound and its preparations for the prevention and treatment of perimenopausal syndrome.

Method used

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  • Traditional Chinese medicine compound preparation for preventing and treating climacteric syndrome and preparation method of traditional Chinese medicine compound preparation
  • Traditional Chinese medicine compound preparation for preventing and treating climacteric syndrome and preparation method of traditional Chinese medicine compound preparation
  • Traditional Chinese medicine compound preparation for preventing and treating climacteric syndrome and preparation method of traditional Chinese medicine compound preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Embodiment 1, the preparation of compound granule

[0051] Raw material ratio (by weight): 9 parts of Ligustrum lucidum, 9 parts of medlar, 7.2 parts of Ophiopogon japonicus, 9 parts of white peony, 6 parts of mulberry leaves, 5.4 parts of chrysanthemum, and 6 parts of Digupi.

[0052] Preparation Process:

[0053] (1) Add Ligustrum lucidum to 60% ethanol of 6 times the total amount, soak for 30 minutes; then reflux extraction at 65°C for 2 times, each 0.5h; filter the extract while it is hot, and the filtrate is at 0.07MPa, Concentrate under reduced pressure at 60°C until the relative density is 1.15 at 45°C to obtain the concentrated alcohol extraction solution and medicinal residues, which are set aside for later use;

[0054] (2) Add wolfberry fruit, Ophiopogon japonicus, Radix Paeoniae Alba, mulberry leaves, chrysanthemum, Digupi, and Ligustrum lucidum dregs in step (1) to 6 times the total amount of medicinal materials and decoct once. Time 1.5h; combine the dec...

Embodiment 2

[0057] Embodiment 2, the preparation of compound capsule

[0058] Raw material ratio (by weight): 15 parts of Ligustrum lucidum, 15 parts of Lycium barbarum, 12 parts of Ophiopogon japonicus, 15 parts of Radix Paeoniae Alba, 10 parts of mulberry leaves, 9 parts of chrysanthemum, and 10 parts of Digupi.

[0059] Preparation Process:

[0060] (1) Add Ligustrum lucidum to 80% ethanol of 8 times the total amount, soak for 30min; then reflux extraction at 75°C for 2 times, each time for 1h; Concentrate under reduced pressure at 45°C until the relative density is 1.15 at 45°C to obtain the concentrated alcohol extraction solution and medicinal residues, which are kept separately for later use;

[0061] (2) Add wolfberry fruit, Ophiopogon japonicus, Radix Paeoniae Alba, mulberry leaves, chrysanthemum, Digupi, and Ligustrum lucidum dregs in step (1) to 8 times the total amount of medicinal materials and decoct twice. 2 hours; combine the decoctions, filter while hot, and concentrate...

Embodiment 3

[0064] Embodiment 3, the preparation of compound pill

[0065] Raw material ratio (by weight): 21 parts of Ligustrum lucidum, 21 parts of medlar, 16.8 parts of Ophiopogon japonicus, 21 parts of white peony, 14 parts of mulberry leaves, 12.6 parts of chrysanthemum, and 14 parts of Digupi.

[0066] Preparation Process:

[0067] (1) Add Ligustrum lucidum to 10 times the total amount of absolute ethanol, soak for 30 minutes; then reflux extraction at 85°C for 2 times, each 1.5h; filter the extract while it is hot, and the filtrate is at 0.07MPa, Concentrate under reduced pressure at 60°C until the relative density is 1.15 at 45°C to obtain the concentrated alcohol extraction solution and medicinal residues, which are set aside for later use;

[0068] (2) Add wolfberry fruit, Ophiopogon japonicus, Radix Paeoniae Alba, mulberry leaves, chrysanthemum, Digupi, and Ligustrum lucidum dregs in step (1) to 10 times the total amount of medicinal materials and decoct 3 times. 2.5 hours; c...

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Abstract

The invention provides a traditional Chinese medicine compound preparation for preventing and treating climacteric syndrome, and belongs to the field of traditional Chinese medicine. According to thetraditional Chinese medicine compound preparation, ligustrum lucidum ait, fructus lycii, radix ophiopogonis, white peony root, mulberry leaf, chrysanthemum and cortex lycii radicis are used as bulk pharmaceutical chemicals for composition, so that the efficacy of each medicine is synergistic, and the effects of nourishing liver and kidney and clearing heat and benefiting Yin are achieved. The results of pharmacodynamic experiments show that the traditional Chinese medicine compound preparation has a certain prevention and treatment effect on the climacteric syndrome. The medicine is made of pure natural Chinese medicinal materials as raw materials and is prepared into an oral preparation by using the conventional pharmacological process and auxiliary materials, and the traditional Chinesemedicine compound preparation for preventing and treating the climacteric syndrome is safe and non-toxic, and is further an ideal health care product.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to a traditional Chinese medicine compound preparation for preventing and treating perimenopausal syndrome and a preparation method thereof. Background technique [0002] Peri-menopausal syndrome (PMS) is a series of symptoms mainly caused by autonomic nervous dysfunction caused by ovarian function decline, hypothalamus and pituitary function degeneration, and estrogen reduction in women. In women before and after menopause, the kidney qi gradually declines, the tiangui will be exhausted, and the essence and blood are deficient. This is a gradual decline in sexual physiology. The pathogenesis is complicated, so the clinical manifestations are different. In recent years, fast-paced life and work often bring great mental pressure to modern people. Under the pressure of life and work, the special physiological structure of women tends to decrease the sensitivity of the pituit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61P15/12
CPCA61K9/0053A61K36/287A61K36/605A61K36/638A61K36/65A61K36/71A61K36/815A61K36/8968A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61P15/12A61K2300/00
Inventor 郭玫邵晶王志旺李娟武权生刘广义
Owner GANSU UNIV OF CHINESE MEDICINE
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