5results about How to "Reduce writhing" patented technology

This invention belongs to the field of biopharmaceuticals and provides a keratin YK93-6, its encoding nucleic acid molecule, an expression vector containing the nucleic acid molecule, a host cell containing the expression vector or whose genome integrates the nucleic acid molecule, as well as a preparation method and a pharmaceutical composition thereof. It also provides the application of the above-mentioned keratin YK93-6 and other products in the preparation of drugs for treating benign prostatic hyperplasia, lymphoma, melanoma, analgesia, lactation, breast cancer, lung cancer, uterine fibroids, coagulation, etc.

This invention belongs to the field of biopharmaceuticals and provides a keratin YK93-9, its encoded nucleic acid molecule, an expression vector containing the nucleic acid molecule, a host cell containing the expression vector or whose genome integrates the nucleic acid molecule, as well as a preparation method and a pharmaceutical composition thereof. It also provides the application of the above-mentioned keratin YK93-9 and other substances in the preparation of drugs for treating lung cancer, lymphoma, breast cancer, melanoma, uterine fibroids, benign prostatic hyperplasia, etc.

The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition for promoting blood circulation to remove meridian obstruction and a preparation method and application thereof. The traditional Chinese medicine composition for promoting blood circulation to remove meridian obstruction is prepared from the following raw materials in parts by weight: 15 to 25 parts of herba taxilli, 18 to 22 parts of semen cuscutae, 8 to 15 parts of radix angelicae sinensis, 3 to 6 parts of radix salviae miltiorrhizae, 18 to 22 parts of radix dipsaci, 8 to 15 parts of herba leonuri, 12 to 18 parts of radix paeoniae alba, 25 to 35 parts of rhizoma dioscoreae, 6 to 12 parts of rhizoma chuanxiong, 3 to 8 parts of radix aucklandiae, 6 to 12 parts of fructus nelumbinis, 10 to 15 parts of radix scutellariae and 12 to 20 parts of roasted rhizoma atractylodis macrocephalae. The traditional Chinese medicine composition obtained through the composition, the dosage and the proportion of the components can remarkably reduce the whole blood viscosity, hematocrit and plasma viscosity of a rat with a blood stasis syndrome, can remarkably reduce the twisting frequency of an experimental dysmenorrhea model rat, has the effects of activating blood, resisting inflammation, dredging collaterals and relieving pain, and has the effect superior to that of each pair of components.

This invention provides a traditional Chinese medicine preparation for promoting blood circulation and relieving pain, and its preparation method, relating to the field of traditional Chinese medicine pharmaceutical technology. The preparation is made from the following parts by weight of traditional Chinese medicine raw materials: 10-30 parts of Polygonatum sibiricum, 10-30 parts of Spatholobus suberectus, 10-30 parts of Curcuma longa, 5-20 parts of Sparganium stoloniferum, 5-20 parts of Areca catechu peel, 5-20 parts of Polygonum hydropiper, 5-20 parts of Rhizoma Scutellariae, 1-5 parts of Artemisia argyi, 5-20 parts of Solanum nigrum, 5-20 parts of Catechu, 10-30 parts of Scutellaria barbata, 5-20 parts of Aristolochia debilis, 10-30 parts of Astragalus membranaceus, and 5-20 parts of Artemisia argyi oil. The traditional Chinese medicine preparations described in this invention differ from those that typically enhance the efficacy of a single herb. Instead, they exhibit a synergistic relationship where one plus one equals more than two. The principal, assistant, adjuvant, and guide herbs complement each other, combining both tonifying and purging effects. This approach effectively promotes the dissipation of blood stasis, unblocks the flow of qi and blood in the meridians, eliminates local inflammation, and reduces swelling and pain. Simultaneously, it nourishes the tendons and bones, supports the body's vital energy, and enhances the body's ability to resist pathogens and repair damage. Thus, it comprehensively alleviates pain caused by various factors, achieving the goals of promoting blood circulation, removing blood stasis, clearing the meridians, reducing inflammation and swelling, and relieving pain.

The application discloses application of high gold line orchid extract in preparation of medicines or health products for treating or relieving pain, wherein the high gold line orchid extract is at least one of high gold line orchid alcohol extract, high gold line orchid polysaccharide or monomer compound of macfarlanea glycoside. Experimental results show that the high gold line orchid alcohol extract, the high gold line orchid polysaccharide and the monomer compound of macfarlanea glycoside all have good in-vivo analgesic activity, can significantly inhibit acute or chronic pain caused by chemical stimulation and thermal stimulation, can effectively reduce the writhing frequency of mice induced by intraperitoneal injection of acetic acid, prolong the pain reaction time of mice, and improve the pain threshold of mice in a hot tail-flick test. The above results show that the high gold line orchid extract can be used for clinical drug treatment of various pains, especially inflammatory pain, or be prepared into health products for relieving pain.