11results about How to "Clear treatment effect" patented technology

The invention relates to the technical field of data mining, in particular to a method for constructing a myocardial rehabilitation decision support system based on case-based reasoning. The method comprises the following steps: collecting and fusing historical cardiomyopathology case data, and carrying out sensitive feature desensitization to obtain desensitization data; dividing myocardial rehabilitation cases and integrating abnormal electrocardiogram waveform characteristics to obtain abnormal waveform data of the rehabilitation cases; constructing an abnormal waveform detection model, and detecting abnormal waveforms by using the abnormal waveform detection model to obtain abnormal electrocardiogram waveform myocardial case data; performing trend analysis on the abnormal waveform data, and calculating myocardial rehabilitation influence factors; evaluating the doctor treatment priority based on the influence factors, and constructing a treatment doctor recommendation model; and in combination with the recommendation model and the detection model, constructing and optimizing a myocardial rehabilitation decision-making system so as to obtain a myocardial rehabilitation decision-making support system. According to the invention, based on data mining, the accuracy and effectiveness of myocardial rehabilitation research on historical cardiomyopathology cases are realized.

The invention provides a traditional Chinese medicine composition for treating dry eyes as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine compositions. The preparation method of the traditional Chinese medicine composition comprises the following steps: taking 3-12 parts by weight of tripterygium wilfordii and 3-12 parts by weight of mint as raw material medicines, mixing, adding water, decocting, carrying out solid-liquid separation, and concentrating the filtrate to obtain the traditional Chinese medicine composition. According to the invention, tripterygium wilfordii is taken as a main medicine and is matched with mint with the effect of dispelling wind and heat to jointly form the eye fumigating prescription capable of dispelling wind and clearing heat, and the eye fumigating prescription comprises active ingredients such as triptolide, tripterine and the like, and can regulate and control inflammatory response of ocular surface; local administration is carried out by adopting an ultrasonic atomization method, so that liver and kidney injury caused by liver and kidney metabolism of oral medicines can be avoided, most of active ingredients only play roles in eyes and do not enter blood circulation, the toxicity of tripterygium wilfordii is reduced, only anti-inflammatory and immunosuppression efficacy of tripterygium wilfordii is taken, local administration directly reaches a disease site, and the treatment effect on dry eyes is definite.

The invention relates to application of tsRNA-3025a as a prognostic marker of acute myocardial infarction and a treatment target spot of myocardial ischemia reperfusion injury. A DNA (Deoxyribonucleic Acid) sequence corresponding to the tsRNA-3025a is shown as SEQ ID NO: 1: 5 '-ATCCTGCCGACTACGCCA-3'. The tsRNA-3025a can be used for treating acute myocardial infarction and myocardial ischemia reperfusion injury. In the aspect of prognosis, a detection kit is provided, and the risk of heart failure and short-term adverse events of a patient is evaluated by quantitatively detecting the expression level of the tsRNA. In the aspect of treatment, the invention provides the application of the anti-tagomir for inhibiting the function or expression of tsRNA-3025a in the preparation of the medicine for treating the myocardial ischemia reperfusion injury, and the anti-tagomir is subjected to specific chemical modification. A novel biomarker is provided for prognosis risk stratification of acute myocardial infarction, and an effective treatment strategy is provided for prevention and treatment of myocardial ischemia-reperfusion injury.

This invention belongs to the field of medical technology, specifically relating to the application of mitochondrial transplantation to regulate the immune-metabolic network in the treatment of myocardial dysfunction after cardiac arrest. The mitochondrial transplantation is performed within 0.5-2 hours after the restoration of spontaneous cardiac circulation. This technical solution, through multi-omics integrated analysis, proposes that mitochondrial transplantation exerts a cardioprotective effect by regulating the immune-metabolic-mitochondrial triaxial synergistic network, providing a new research direction for the precision treatment of myocardial dysfunction after cardiac arrest.

The invention discloses a saRNA drug delivery system, which is composed of a saRNA drug and lipid nanoparticles, and the lipid nanoparticles are composed of ionizable cationic lipid, neutral phospholipid, sterol lipid and PEGylated phospholipid. The delivery system is stable in structure and good in dispersity, and can be prepared into an injection-grade nano preparation; meanwhile, saRNA medicine can be effectively delivered to a cell nucleus, the mRNA level of a target gene FXR is remarkably up-regulated, and a definite treatment effect is achieved.

This application discloses the use of itaconic acid derivatives in the preparation of drugs for treating candidemia, belonging to the field of biomedical technology. The itaconic acid derivatives proposed in this application are dimethyl itaconic acid and / or 4-octyl itaconic acid. Dimethyl itaconic acid exhibits a dose-dependent therapeutic effect in model mice, with an optimal dose of 1200 mg / kg improving survival rate and reducing kidney damage; 4-octyl itaconic acid can enhance the anti-Candida albicans ability of macrophages and regulate the expression of inflammatory factors. The application of the itaconic acid derivatives proposed in this application in the treatment of candidemia works through immunomodulation, circumventing fungal resistance. Furthermore, the drugs are low in toxicity, have good biocompatibility, and use a universal experimental system, providing a new approach for the clinical treatment of candidemia with broad application prospects. This application also protects pharmaceutical compositions for treating candidemia with dimethyl itaconic acid and / or 4-octyl itaconic acid as active ingredients.

The invention provides a small molecule compound A5 with a good treatment effect on metabolism-related fatty liver diseases, a novel pyrene derivative A5 is successfully prepared through an organic synthesis approach, and the novel pyrene derivative A5 is proved to have a definite treatment effect on the metabolism-related fatty liver diseases on the basis of in-vivo and in-vitro pharmacodynamic experiments. The invention further provides an application of the hydroxypyrene derivative A5 in preparation of drugs for preventing and / or treating metabolism-related fatty liver diseases. The compound can remarkably improve characteristic pathological changes of the metabolism-related fatty liver disease, including regulation of dyslipidemia, inhibition of hepatocyte vacuolar degeneration and delay of liver fibrosis progress, shows the advantage of multi-target treatment, and shows a remarkable curative effect in treatment of the metabolism-related fatty liver disease.

The invention belongs to the field of biological medicine. The technical problem to be solved by the invention is to provide a new choice for treatment of obesity and non-alcoholic fatty liver diseases. According to the technical scheme for solving the technical problem, the novel polypeptide is provided, and the polypeptide contains an ERK2 substrate binding pocket structural domain and has the function of blocking combination of Arg1 and ERK2. The polypeptide disclosed by the invention has the characteristics of simplicity in preparation and obvious treatment effect, and has a very good application prospect.

The application discloses a traditional Chinese medicine composition for preventing and treating Hashimoto's thyroiditis and complications (thyroid nodules and / or mammary gland hyperplasia), which is prepared from raw medicinal materials in the following proportions: 1-10 parts of ginseng, 1-15 parts of astragalus, 1-40 parts of fritillaria, 1-20 parts of prunella vulgaris, 1-20 parts of smilax, 1-18 parts of curcuma, and 1-19 parts of scutellaria. In addition, the application also discloses a preparation method and application of the traditional Chinese medicine composition. Clinical efficacy and pharmacological researches prove that the traditional Chinese medicine composition has multiple effects of clearing heat and resolving toxins, promoting blood circulation to remove blood stasis, and tonifying qi and invigorating the spleen, so that the purposes of dispersing thyroid nodules, reducing mammary gland hyperplasia, and improving Hashimoto's thyroiditis symptoms are achieved.

The present application relates to the technical field of traditional Chinese medicine preparation, and discloses a traditional Chinese medicine composition with cough-relieving effect and a preparation method thereof, which is composed of one or both of crude drug powder of summerleaf euonymus and summerleaf euonymus extract, and contains the following components in mass fraction: 1-15 parts of summerleaf euonymus crude drug powder and 1-10 parts of summerleaf euonymus extract.In the present application, the medicinal activity of summerleaf euonymus in the field of cough relief is found and verified, the therapeutic effect of summerleaf euonymus on various types of cough is determined, the application limitation of summerleaf euonymus in the prior art, i.e. only used for promoting blood circulation to remove meridian obstruction and relieving qi stagnation and pain, is broken, and the clinical application range and medicinal value of summerleaf euonymus are greatly expanded.

The present invention relates to the field of data mining technology, and in particular to a method for constructing a myocardial rehabilitation decision support system based on case reasoning. The method comprises the following steps: collecting and integrating historical myocardial case data, desensitizing sensitive features, and obtaining desensitized data; dividing myocardial rehabilitation cases and integrating abnormal electrocardiogram waveform features to obtain abnormal waveform data of rehabilitation cases; constructing an abnormal waveform detection model, and using it to detect abnormal waveforms to obtain abnormal electrocardiogram waveform myocardial case data; performing trend analysis on abnormal waveform data and calculating myocardial rehabilitation influencing factors; evaluating the doctor's treatment priority based on the influencing factors, and constructing a treatment doctor recommendation model; combining the recommendation model and the detection model, constructing and optimizing the myocardial rehabilitation decision system, thereby obtaining a myocardial rehabilitation decision support system. Based on data mining, the present invention realizes the accuracy and effectiveness of myocardial rehabilitation research on historical myocardial cases.