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Traditional Chinese medicine composition for angina pectoris and preparation method thereof

A composition and technology for angina pectoris, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of failure to achieve the effect, and achieve the effect of calm drug properties, dilating coronary arteries, and significant and reliable curative effect

Inactive Publication Date: 2014-11-12
刘新宇
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there are new drugs for the treatment of angina pectoris in clinical practice, including western medicine and Chinese patent medicine and new interventional treatment methods, but these have failed to achieve truly satisfactory results

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A traditional Chinese medicine composition for angina pectoris, characterized in that it is prepared from the following raw materials in proportion by weight,

[0036] 30 parts of Panax notoginseng, 30 parts of Inulae root, 30 parts of polygala, 28 parts of mulberry, 28 parts of Ophiopogon japonicus,

[0037] 27 parts of astragalus, 27 parts of Sanlong, 25 parts of ginkgo biloba, 25 parts of salvia miltiorrhiza, 25 parts of dogwood,

[0038] 22 parts of Dendrobium, 22 parts of japonica rice, 20 parts of Shouwu, 20 parts of Dijincao, 20 parts of Nyxa chinensis,

[0039] 20 parts of Gardenia, 20 parts of Bergamot, 18 parts of Clematis, 17 parts of Angelica, 17 parts of Notopterygium,

[0040] 15 parts of cardamom, 15 parts of gorgon, 15 parts of golden cherry, 15 parts of wolfberry, 10 parts of kudzu root,

[0041] 10 parts of myrrh, 10 parts of dandelion, 10 parts of herb.

[0042] Its preparation method of Chinese medicine composition of the present invention is:

...

Embodiment 2

[0051] clinical experiments

[0052] Anti-hypoxia experiment

[0053] 1. Animals:

[0054] Test animals: healthy mice 20-25g

[0055] 2. Drugs and reagents:

[0056] Test drug, the drug prepared in Example 1; positive control drug: propranolol, provided by Tianjin Lisheng Pharmaceutical Co., Ltd.; isoproterenol hydrochloride, provided by Shanghai Hefeng Pharmaceutical Co., Ltd.

[0057] 3. Experimental method:

[0058] 40 mice were randomly divided into 4 groups, 10 in each group, the normal group and the model group were given normal saline, the experimental group was given the pharmaceutical composition prepared by the embodiment 20mg / kg, and the positive control group was given propranolol 20mg / kg. After gavage for 1 hour, the normal group was subcutaneously injected with equal volume of normal saline, and the other groups were subcutaneously injected with isoproterenol hydrochloride 20 mg / kg. After 15 minutes, they were put into a 250 mL jar containing 15 g of soda l...

Embodiment 3

[0072] clinical information

[0073] Select 101 patients diagnosed with angina pectoris and divide them into two groups randomly. The treatment group consisted of 51 cases, including 27 males and 24 females, aged 50 to 74 years, with an average of 61.37±2.35 years, and the course of disease was six months to seven years. There were 50 cases in the control group, 26 males and 24 females, aged 49 to 75 years, with an average of 60.45±3.37 years, and the course of disease was 5 months to 8 years. There was no significant difference in gender, age, and course of disease between the two groups before treatment ( P>0.05), comparable.

[0074] Diagnostic criteria

[0075] Western medicine diagnostic criteria

[0076] Refer to "Suggestions for the Diagnosis and Treatment of Unstable Angina Pectoris" by the Cardiovascular Disease Branch of the Chinese Medical Association.

[0077] Diagnosis and Syndrome Differentiation Standards of TCM

[0078] The TCM syndrome differentiation st...

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Abstract

The invention relates to a traditional Chinese medicine composition for angina pectoris and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30 parts of panax notoginseng, 30 parts of flos inulae root, 30 parts of polygala root, 28 parts of mulberry fruit, 28 parts of radix ophiopogonis, 27 parts of radix astragali, 27 parts of rhizoma sparganii, 25 of folium ginkgo, 25 parts of salvia miltiorrhiza, 25 parts of cornus officinalis, 22 parts of nobile dendrobium, 22 parts of japonica rice, 20 parts of radix polygoni multiflori, 20 parts of humifuse euphorbia herbs, 20 parts of nux vomica, 20 parts of cape jasmine, 20 parts of fingered citron, 18 parts of radix clematidis, 17 parts of angelica sinensis, 17 parts of notopterygium roots, 15 parts of fructus amomi rotundus, 15 parts of semen euryales, 15 parts of fructus rosae laevigatae, 15 parts of fructus lycii, 10 parts of root kudzuvine, 10 parts of myrrh, 10 parts of dandelion and 10 parts of rhizoma atractylodis. The traditional Chinese medicine composition disclosed by the invention treats both symptoms and root causes of angina pectoris, has no side effect, toxicity or harm to the human body, low in price and simple to prepare; therefore, the traditional Chinese medicine composition has a broad application prospect.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for angina pectoris and a preparation method thereof. Background technique [0002] Angina pectoris is a clinical syndrome mainly characterized by paroxysmal chest pain or chest discomfort caused by coronary insufficiency, myocardial acute, temporary ischemia and hypoxia. It is characterized by paroxysmal and compressive pain in the anterior chest, which may be accompanied by other symptoms. The pain is mainly located at the back of the sternum and can radiate to the precordial area and left upper limb. It often occurs during labor or emotional agitation, and each attack lasts for 3 to 5 minutes. , can be several days once, or several times a day. The disease is more common in men, and fatigue, emotional agitation, satiety, cold, rainy weather, and acute circulatory failure are common causes. It is mor...

Claims

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Application Information

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IPC IPC(8): A61K36/9062A61K9/48A61P9/10
Inventor 刘新宇
Owner 刘新宇
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