Traditional Chinese medicine composition for angina pectoris and preparation method thereof

A composition and technology for angina pectoris, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of failure to achieve the effect, and achieve the effect of calm drug properties, dilating coronary arteries, and significant and reliable curative effect

Inactive Publication Date: 2014-11-12
刘新宇
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there are new drugs for the treatment of angina pectoris in clinical practice, including western medicine an

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0034] Example 1

[0035] A Chinese medicinal composition for angina pectoris, which is characterized in that it is prepared from the following weight ratio raw materials:

[0036] 30 parts of Panax notoginseng, 30 parts of Inula Root, 30 parts of Polygala, 28 parts of Mulberry, 28 parts of Ophiopogon japonicus,

[0037] 27 parts of Astragalus, 27 parts of Triangle, 25 parts of Ginkgo biloba, 25 parts of Salvia, 25 parts of Cornus,

[0038] 22 copies of dendrobium, 22 copies of japonica rice, 20 copies of Shouwu, 20 copies of Dijincao, 20 copies of Maqianzi,

[0039] 20 pieces of gardenia, 20 pieces of bergamot, 18 pieces of Weilingxian, 17 pieces of angelica, 17 pieces of Qianghuo,

[0040] 15 parts of grass cardamom, 15 parts of gorgon, 15 parts of golden cherry seeds, 15 parts of wolfberry, 10 parts of kudzu root,

[0041] 10 parts of myrrh, 10 parts of dandelion, 10 parts of Cangzhu.

[0042] The preparation method of the traditional Chinese medicine composition of the present inventio...

Example Embodiment

[0050] Example 2

[0051] clinical experiments

[0052] Anti-hypoxia test

[0053] 1. Animals:

[0054] Tested animals: 20-25g healthy mice

[0055] 2. Drugs and reagents:

[0056] The test drug was the drug prepared in Example 1; the positive control drug: Propranolol, provided by Tianjin Lisheng Pharmaceutical Co., Ltd.; and isoproterenol hydrochloride, provided by Shanghai Hefeng Pharmaceutical Co., Ltd.

[0057] 3. Experimental method:

[0058] 40 mice were randomly divided into 4 groups, 10 mice in each group. Normal group and model group were given normal saline by gavage, experimental group was given 20mg / kg of the pharmaceutical composition prepared in the example, and positive control group was given propranolol 20mg / kg. After intragastric administration for 1 hour, the normal group was injected with equal volume of normal saline subcutaneously, and the other groups were injected with 20 mg / kg isoproterenol hydrochloride subcutaneously. After 15 minutes, they were put into a 25...

Example Embodiment

[0071] Example 3

[0072] clinical information

[0073] 101 patients diagnosed with angina pectoris were selected and randomly divided into two groups. There were 51 cases in the treatment group, including 27 males and 24 females, aged from 50 to 74 years old, with an average of 61.37±2.35 years old, and the course of disease was half a year to 7 years. There were 50 cases in the control group, including 26 males and 24 females, aged from 49 to 75 years old, with an average of 60.45±3.37 years, and the course of disease was 5 months to 8 years. There was no significant difference in gender, age, and course of disease between the two groups before treatment ( P>0.05), which is comparable.

[0074] Diagnostic criteria

[0075] Western medicine diagnostic criteria

[0076] Refer to "Diagnosis and Treatment Recommendations for Unstable Angina Pectoris" by the Cardiovascular Branch of the Chinese Medical Association.

[0077] TCM diagnosis and syndrome differentiation standards

[0078] Th...

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PUM

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Abstract

The invention relates to a traditional Chinese medicine composition for angina pectoris and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30 parts of panax notoginseng, 30 parts of flos inulae root, 30 parts of polygala root, 28 parts of mulberry fruit, 28 parts of radix ophiopogonis, 27 parts of radix astragali, 27 parts of rhizoma sparganii, 25 of folium ginkgo, 25 parts of salvia miltiorrhiza, 25 parts of cornus officinalis, 22 parts of nobile dendrobium, 22 parts of japonica rice, 20 parts of radix polygoni multiflori, 20 parts of humifuse euphorbia herbs, 20 parts of nux vomica, 20 parts of cape jasmine, 20 parts of fingered citron, 18 parts of radix clematidis, 17 parts of angelica sinensis, 17 parts of notopterygium roots, 15 parts of fructus amomi rotundus, 15 parts of semen euryales, 15 parts of fructus rosae laevigatae, 15 parts of fructus lycii, 10 parts of root kudzuvine, 10 parts of myrrh, 10 parts of dandelion and 10 parts of rhizoma atractylodis. The traditional Chinese medicine composition disclosed by the invention treats both symptoms and root causes of angina pectoris, has no side effect, toxicity or harm to the human body, low in price and simple to prepare; therefore, the traditional Chinese medicine composition has a broad application prospect.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for angina pectoris and a preparation method thereof. Background technique [0002] Angina pectoris is a clinical syndrome mainly characterized by paroxysmal chest pain or chest discomfort caused by coronary insufficiency, myocardial acute, temporary ischemia and hypoxia. It is characterized by paroxysmal and compressive pain in the anterior chest, which may be accompanied by other symptoms. The pain is mainly located at the back of the sternum and can radiate to the precordial area and left upper limb. It often occurs during labor or emotional agitation, and each attack lasts for 3 to 5 minutes. , can be several days once, or several times a day. The disease is more common in men, and fatigue, emotional agitation, satiety, cold, rainy weather, and acute circulatory failure are common causes. It is mor...

Claims

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Application Information

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IPC IPC(8): A61K36/9062A61K9/48A61P9/10
Inventor 刘新宇
Owner 刘新宇
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