Probiotic tablet with immunity enhancing function and preparation method thereof

A technology of probiotic tablets and immune enhancement, applied in the direction of biochemical equipment and methods, methods based on microorganisms, and the function of food ingredients, etc., to achieve the effects of high live bacteria content, improved organ index, and simple process

Active Publication Date: 2020-10-09
HANGZHOU WAHAHA TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

We can start with gut microbes and try to find new ways to regulate immunity, so as to overcome the defects of existing therapeutic drugs and side effects of therapeutic methods

Method used

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  • Probiotic tablet with immunity enhancing function and preparation method thereof
  • Probiotic tablet with immunity enhancing function and preparation method thereof
  • Probiotic tablet with immunity enhancing function and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0067] Preparation of Lactobacillus helveticus WHH2580 freeze-dried powder:

[0068] 1) Preparation of medium; medium formula is desalted whey powder 15-50g, casein hydrolyzate 2-15g, tryptone 3-15g, soybean peptone 7-20g, yeast powder 3-6g, sodium citrate 5- 15g, dipotassium hydrogen phosphate 1-5g, magnesium sulfate 0.4-0.8g, manganese sulfate monohydrate 0.2-0.5g, tomato juice 5-30ml, water 1000mL; adjust its pH to 6.5±0.2.

[0069] 2) Preparation of the strain protecting agent; the formula of the strain protecting agent is 20-150 g / L of skim milk, 30-100 g / L of sucrose, and 5-45 g / L of glycerin.

[0070] 3) Inoculate Lactobacillus helveticus WHH2580 in the fermentation substrate with 2%-10% inoculation amount for fermentation and culture; the fermentation temperature is 34-45° C., the fermentation time is 6-18 hours, and the pH is controlled at 4.0-6.0 during the fermentation process.

[0071] 4) After the fermentation, take the fermentation product and centrifuge; the ce...

Embodiment 1

[0083] A probiotic tablet with immune function enhancement, comprising 10 parts of Lactobacillus helveticus freeze-dried powder, 5 parts of acerola cherry powder, 84.5 parts of direct-pressed sorbitol, and 0.5 part of magnesium stearate. The number of viable bacteria in the freeze-dried powder of Lactobacillus helveticus is 3.5×10 10 CFU / g.

[0084] The preparation of described Lactobacillus helveticus lyophilized powder:

[0085] 1) Preparation of medium; said medium formula is desalted whey powder 15g, casein hydrolyzate 13g, tryptone 3g, soybean peptone 20g, yeast powder 6g, sodium citrate 5g, dipotassium hydrogen phosphate 3g, magnesium sulfate 0.4g, manganese sulfate monohydrate 0.3g, tomato juice 15ml, water 1000mL; adjust its pH to 6.5.

[0086] 2) Preparation of bacterial strain protective agent; the formula of bacterial strain protective agent is 90 g / L of skim milk, 80 g / L of sucrose, and 30 g / L of glycerin.

[0087] Lactobacillus helveticus WHH2580 was inoculated i...

Embodiment 6

[0102] A probiotic tablet capable of enhancing immune function, comprising 3 parts of Lactobacillus helveticus freeze-dried powder, 10 parts of acerola cherry powder, 86 parts of direct-pressed maltitol, and 1 part of magnesium stearate. The number of viable bacteria in the freeze-dried powder of Lactobacillus helveticus is 2.7×10 11 CFU / g.

[0103] Preparation of Lactobacillus helveticus freeze-dried powder:

[0104] 1) Preparation of culture medium; the formula of the culture medium is 40 g of desalted whey powder, 10 g of casein hydrolyzate, 8 g of tryptone, 15 g of soybean peptone, 5 g of yeast powder, 8 g of sodium citrate, 2 g of dipotassium hydrogen phosphate, and magnesium sulfate 0.6g, manganese sulfate monohydrate 0.4g, tomato juice 20ml, water 1000mL; adjust its pH to 6.5.

[0105] 2) Preparation of bacterial strain protective agent; the formula of bacterial strain protective agent is 110 g / L of skim milk, 100 g / L of sucrose, and 60 g / L of glycerin.

[0106] Lact...

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Abstract

The invention relates to the field of foods, and discloses a probiotic tablet with an immunity enhancing function and a preparation method of the probiotic tablet. The tablet comprises lactobacillus helveticus freeze-dried powder, acerola cherry powder, a direct-compression auxiliary material and magnesium stearate, can improve in-vitro splenic lymphocyte proliferation and interleukin IL-12 secretion of splenic lymphocytes, promotes human colon cancer epithelial cells HT-29 to secrete interleukin IL-8, and can be used for enhancing immunity. The selected lactobacillus helveticus WHH2580 strainhas excellent acid resistance, cholate resistance and adhesion performance; after the strain is inactivated, the immunity of the organism can still be improved by improving and regulating the organ index, the non-specific immunity and the specific immune response of the organism, so that the product stability and the shelf life of the strain are longer.

Description

technical field [0001] The invention relates to the field of food, in particular to a probiotic tablet with immune-enhancing function and a preparation method thereof. Background technique [0002] With the acceleration of urbanization and the prevalence of unhealthy lifestyles among residents, various diseases and sub-health populations caused by low immunity in my country have increased dramatically. Low immunity causes the body to not normally play a protective role, and is extremely susceptible to infections such as bacteria, viruses, and fungi. The most direct manifestation is that it is easy to get sick. Due to frequent illnesses, the consumption of the body has been aggravated, and the manifestations of low immunity such as physical weakness, malnutrition, listlessness, fatigue, loss of appetite, and sleep disturbance have appeared to varying degrees. It takes a long time to recover from each illness, and often relapses. If things go on like this lead to poor physic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/135A23L19/00A23L33/16C12N1/20C12R1/225
CPCC12N1/20A23V2002/00A23V2400/147A23V2200/324
Inventor 任学良葛红娟陈丽娥陈苏李言郡翁璐溦陈彩玲郑志瑶陈作国孙盛俞赟霞
Owner HANGZHOU WAHAHA TECH
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