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Active targeting nano ball for photo-thermally treating tumor and preparation method and appliance thereof

A technology of active targeting and photothermal therapy, which is applied in the field of medicine, can solve the problems of poor treatment effect and large side effects of drugs, and achieve the effect of stable and reliable method, overcoming large side effects and convenient use

Inactive Publication Date: 2015-11-18
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the above situation, in order to overcome the defects of the prior art, the object of the present invention is to provide an active targeting nanosphere for photothermal treatment of tumors and its preparation method and application, which can effectively solve the problem of large side effects and low therapeutic effect of existing tumor treatment drugs. bad question

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  • Active targeting nano ball for photo-thermally treating tumor and preparation method and appliance thereof

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Embodiment 1

[0016] In concrete implementation, the present invention is realized by the following steps:

[0017] 1) Synthesis of copper sulfide nanoparticles: weigh 0.4mmoLCuCl 2 Dissolve in 8mL of povidone (PVP) solution with a concentration of 0.2g / mL, and form a light blue solution under magnetic stirring; another 1.2mmoLNa 2 Dissolve S in 8mL ultrapure water to form Na 2 S solution, the light blue solution and Na 2 The S solutions were combined, placed in a reaction kettle, reacted in a water bath at 180°C for 12h, and centrifuged at 1200r / min for 10min to obtain a black-green precipitate, which was washed 3 times with 40mL ethanol, dried under vacuum at 60°C to form copper sulfide nanoparticles ( PVP-Cu 2-x S);

[0018] 2) Preparation of passive targeting nanospheres: Weigh 6 mg copper sulfide nanoparticles (PVP-Cu 2-x S) Dissolve in 8 mL of acetic acid solution containing chitosan, the mass concentration of the acetic acid solution is 1%, the content of chitosan in the acetic ...

Embodiment 2

[0021] The present invention can also be realized by the following steps in concrete implementation:

[0022] 1) Synthesis of copper sulfide nanoparticles: weigh 0.5mmoLCuCl 2 Dissolve in 10mL of povidone (PVP) solution with a concentration of 0.2g / mL, and form a light blue solution under magnetic stirring; another 1.5mmoLNa 2 Dissolve S in 10mL ultrapure water to form Na 2 S solution, the light blue solution and Na 2 The S solutions were combined, placed in a reaction kettle, reacted in a water bath at 180°C for 12h, and centrifuged at 1200r / min for 10min to obtain a black-green precipitate, which was washed 3 times with 50mL ethanol, and dried in vacuum at 60°C to form copper sulfide nanoparticles ( PVP-Cu 2-x S);

[0023] 2) Preparation of passive targeting nanospheres: Weigh 7.5 mg copper sulfide nanoparticles (PVP-Cu 2-x S) Dissolve in 10 mL of acetic acid solution containing chitosan, the mass concentration of the acetic acid solution is 1%, the content of chitosan ...

Embodiment 3

[0026] The present invention can also be realized by the following steps in concrete implementation:

[0027] 1) Synthesis of copper sulfide nanoparticles: weigh 0.6mmoLCuCl 2 Dissolve in 12mL of povidone (PVP) solution with a concentration of 0.2g / mL, and form a light blue solution under magnetic stirring; another 1.8mmoLNa 2 Dissolve S in 12mL ultrapure water to form Na 2 S solution, the light blue solution and Na 2 The S solutions were combined, placed in a reaction kettle, reacted in a water bath at 180°C for 12h, and centrifuged at 1200r / min for 10min to obtain a black-green precipitate, which was washed 3 times with 60mL ethanol, dried under vacuum at 60°C to form copper sulfide nanoparticles ( PVP-Cu 2-x S);

[0028]2) Preparation of passive targeting nanospheres: Weigh 9 mg copper sulfide nanoparticles (PVP-Cu 2-x S) Dissolve in 12 mL of acetic acid solution containing chitosan, the mass concentration of the acetic acid solution is 1%, the content of chitosan in t...

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Abstract

The invention relates to an active targeting nano ball for photo-thermally treating tumor and a preparation method and an appliance thereof, which effectively solve the problems that existing tumor treatment drugs are large in side effect and poor in treatment effect. The method for preparing the active targeting nano ball for photo-thermally treating the tumor comprises steps: copper chloride (CuCl2) is dissolved in povidone solution, sodium sulphide (Na2S) is dissolved in ultrapure water, the CuCl2 solution and the Na2S solution are combined to react, and are subsided and dried to be copper sulfide nano-particles, and the copper sulfide nano-particles are dissolved into acetate solution containing chitosan, thereby forming polyvinyl pyrrolidone- Cu2-xS (PVP-Cu2-xS) solution. Docetaxel is dissolved into methyl alcohol, and is added into the PVP-Cu2-xS solution, and then sodium tripolyphosphate is added, and is subsided to be a passive targeting nano ball. folic acid is added into the passive targeting nano ball, then 1-ethyl-(3- dimethylaminopropyl) carbodiimide hydrochloride is added, and liquid supernatant is removed by centrifuging, thereby obtaining an active targeting nano ball. The method for preparing the active targeting nano ball for photo-thermally treating the tumor is steady and reliable, is steady in product performance, convenient to use, excellent in effect, easy to operate, rich in source of raw materials, low in cost and small in side effect, and can effectively restrain tumor cells from breeding.

Description

technical field [0001] The invention relates to medicine, in particular to an active targeting nanosphere for photothermal treatment of tumors and its preparation method and application. Background technique [0002] The pathophysiological characteristics of tumor tissue are significantly different from those of normal tissue, mainly manifested in the strong vascular permeability of the tumor site. Macromolecular drugs and carriers can penetrate the vascular endothelial cells and enter the tumor tissue through the penetration and retention enhancement effect (that is, the EPR effect). It can accumulate in the tumor site for a long time and at a high concentration. Nanoparticles (NPs), including nanospheres and nanocapsules, are loaded or encapsulated drug molecules into nanomaterials, using the targeting, sustained release and EPR effect of the tumor site, through intravenous injection The nanoparticles are delivered to the tumor site to achieve the purpose of efficient tar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/14A61K31/337A61P35/00
Inventor 祝侠丽张英杰张振中黄河清侯琳张慧娟李鸿基
Owner ZHENGZHOU UNIV
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