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Pt (II) complex with photodynamic tri-negative breast cancer resisting activity as well as preparation method and application of Pt (II) complex

A technology of triple-negative breast cancer and complexes, applied in the field of medicine, to achieve strong inhibitory effects, overcome drug resistance and side effects

Pending Publication Date: 2021-12-28
HUBEI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the application of platinum-based antineoplastic drugs is limited. There are two main reasons: (1) the side effects are more obvious, including nephrotoxicity, neurotoxicity, bone marrow suppression, nausea, vomiting, hair loss and fatigue; Drug resistance is prominent, including endogenous drug resistance and acquired drug resistance

Method used

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  • Pt (II) complex with photodynamic tri-negative breast cancer resisting activity as well as preparation method and application of Pt (II) complex
  • Pt (II) complex with photodynamic tri-negative breast cancer resisting activity as well as preparation method and application of Pt (II) complex
  • Pt (II) complex with photodynamic tri-negative breast cancer resisting activity as well as preparation method and application of Pt (II) complex

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047]Preparation of PT (II) complexes with the following structural formula and its reference (BC-PT complex):

[0048]

[0049] The synthesis route of the PT (II) complex and its reference (BC-PT complex) is as follows:

[0050]

[0051] Among them, r = h or i.

[0052] Specifically, include the following steps:

[0053] 1) The 2,4-dimethylpyrrole (2.00 g, 21 mmol) was dissolved in dichloromethane (150 mL). Under nitrogen protection, 4-chlorocanoyl chloride (1.48 g, 10.5 mmol) was added, and stirred at 25 ° C for 5 min, stirred at 50 ° C for 2 h, cooled to room temperature, vacuum evaporation, residue with toluene (150 ml) and dichlorchloro Methane (25 mL) was dissolved, 5 min, triethylamine (2.53 g, 25 mmol) was added to the reaction mixture, and stirring was stirred at normal temperature for 15 min. In n 2 Under protection, slow add BF 3 · ET 2 O (7.60g, 50 mmol). Thereafter, the magnetic stirring reaction was continued at 50 ° C for 1 h. The solvent was evaporated to room...

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Abstract

The invention belongs to the technical field of research and development of anti-cancer drugs, and particularly relates to a Pt (II) complex with photodynamic tri-negative breast cancer resisting activity and a preparation method and application thereof. According to the invention, iodo-BODIPY with excellent photosensitive activity is used as a photosensitive group, DPA (dimethylamine pyridine) is used as a Pt (II) coordination group, and the Pt (II) complex with photodynamic activity is creatively designed and synthesized. The Pt (II) complex belongs to a novel compound, shows excellent in-vitro tri-negative breast cancer resisting activity, has potential medicinal value and is expected to be used for preparing various tri-negative breast cancer resisting drugs. The structural formula of the Pt (II) complex is as shown in the specification.

Description

Technical field [0001] The present invention belongs to the field of medical technology, particularly relates to an anti TNBC activity Pt (Ⅱ) complex and its preparation method and application of light having a power. Background technique [0002] Breast cancer is a common malignancy in women, breast cancer is the so-called triple-negative breast cancer surgical pathology specimens immunohistochemical monitoring estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor (HER- 2) these three indicators are negative breast cancer, it is a special type of malignant breast cancer. The clinical features of Chinese people TNBC, mainly as follows: (1) mostly younger patients; (2) large mass; (3) lymph node metastasis rate; (4) there is a family history of breast cancer. Breast cancer is a hormone-dependent tumors, endocrine therapy is a primary treatment, because of its triple-negative breast cancer hormone receptor were negative, therefore, the lack o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F15/00A61P35/00
CPCC07F15/0093A61P35/00Y02A50/30
Inventor 王小波王淑平王宇静方霄
Owner HUBEI UNIV OF SCI & TECH
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