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Core-satellite nanocomposites for MRI and photothermal therapy

Inactive Publication Date: 2015-03-05
RGT UNIV OF MICHIGAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides methods, compositions, systems, and kits for using core-satellite nanocomposites for photothermal and MRI imaging applications. The nanocomposites consist of a biocompatible coating surrounding a nanoparticle core that contains a first type of material (e.g., near-infrared photothermal agent material and MRI contrast agent material) and at least one satellite component (e.g., near-infrared optical dye material). The nanocomposites can be used for treating and imaging cancer cells in a subject. The technical effects include improved photothermal therapy and MRI imaging for cancer treatment and diagnosis.

Problems solved by technology

However, various challenges still exist.

Method used

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  • Core-satellite nanocomposites for MRI and photothermal therapy
  • Core-satellite nanocomposites for MRI and photothermal therapy
  • Core-satellite nanocomposites for MRI and photothermal therapy

Examples

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example 1

Core-Satellite Nanocomposites for MRI and / or Photothermal Therapy

[0049]This Examples describes the design of core-satellite hybrid nanocomposites with highly crystallized iron oxide nanoparticles (IONPs) as the core and multiple gold sulfide (Au2S) nanoparticles as satellites attached on the surface polymer coated IONP. In this formulation, the multiple satellites (Au2S) could be used for photothermal therapy, while the IONP core could be used as both photothermal mediator and magnetic resonance imaging (MRI) contrast agent. These nanocomposites could also be used in MRI guidable photothermal therapy. This core-satellite nanocomposite has obvious absorption in near infrared range and the absorption peak could be adjusted. The nanocomposites exhibit an obvious temperature rise without any quenching under laser irradiation in comparison to the water control. These nanocomposites benefit benefited from an antibiofouling polymer coating and can effectively accumulate to tumor sites thro...

example 2

Nanocarrier Highly Packed with NIR Dyes for Effective Tumor Accumulation and Photothermal Therapy

[0079]This Examples describes the preparation and characterization of ‘stealth’ nanocarriers with NIR organic dye for effective tumor accumulation and enhanced PTT.

Experimental Section

Materials

[0080]Iron oxide (III) (FeO(OH), hydrated, catalyst grade, 30-50 mesh), oleic acid (technical grade, 90%), 1-octadecene (technical grade, 90%), anhydrous tetrahydrofuran (THF, 99.8%), IR820, (3-mercaptopropyl)trimethoxysilane (MPTS), ammonium iron (II) sulfate hexahydrate (Fe(NH4)2(SO4)2.6H2O, ACS reagent, 99%), o-phenanthroline monohydrate (ACS reagent, 99%), hydroquinone (ACS reagent, 99%), nitric acid (ACS reagent, 70%), and hydrochloric acid (ACS reagent, 37%) were purchased from Sigma-Aldrich and used directly.

Synthesis of IONPs

[0081]IONPs (15 nm in diameter) were synthesized in organic solvent by thermal decomposition as reported previously [25]. Briefly, a mixture of 0.890 g FeO(OH), 19.8 g ...

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Abstract

The present invention provides methods, compositions, systems, and kits comprising core-satellite nanocomposites useful for photothermal and / or MRI applications (e.g., tumor treatment and / or imaging). In certain embodiments, the core-satellite nanocomposites comprise: i) a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core, and ii) at least one satellite component attached to, or absorbed to, the biocompatible coating. In some embodiments, the nanoparticle core and satellite component are composed of near-infrared photothermal agent material and / or MRI contrast agent material. In further embodiments, the satellite component is additionally or alternatively composed of near-infrared optical dye material.

Description

[0001]The present application claims priority to U.S. Provisional application Ser. No. 61 / 873,941, filed Sep. 5, 2013, which is herein incorporated by reference in its entirety.FIELD OF THE INVENTION[0002]The present invention provides methods, compositions, systems, and kits comprising core-satellite nanocomposites useful for photothermal and / or MRI applications (e.g., tumor treatment and / or imaging). In certain embodiments, the core-satellite nanocomposites comprise: i) a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core, and ii) at least one satellite component attached to, or absorbed to, the biocompatible coating. In some embodiments, the nanoparticle core and satellite component are composed of near-infrared photothermal agent material and / or MRI contrast agent material. In further embodiments, the satellite component is additionally or alternatively composed of near-infrared optical dye material.BACKGROUND[0003]Photothermal therapy (...

Claims

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Application Information

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IPC IPC(8): A61K49/18A61K33/26A61B5/00G01R33/56G01R33/48A61K41/00A61N5/06
CPCA61K49/1824A61K41/0052A61K33/26A61N5/062A61B5/055G01R33/4808A61B5/0075A61B5/0035A61N2005/0659G01R33/5601A61K49/183A61K49/1833A61K49/1851A61K49/1827
Inventor CHEN, HONGWEISUN, DUXIN
Owner RGT UNIV OF MICHIGAN
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