82 results about "Formic Acid Esters" patented technology

A method for making the benzoate salt of 4-[5-[(3S)-3-aminopyrrolidine-1-carbonyl]-2-[2-fluoro-4-(2-hydroxy-2-methyl-propyl)phenyl]-2-fluoro-benzonitrile, designated compound (A), and methods for using compound (A) are provided.

Provided herein are methods for preparing crystalline forms of (R)-5-carbamoylpyridin-3-yl-2-methyl-4-(3-(trifluoromethoxy)benzyl)piperazine-1-carboxylate.

The invention discloses a novel 3-formyl-2-methyl-4-(methylthio) benzoate compound as shown in a general formula VI, wherein R is an ester group, carboxylic acid, amide or cyano group. The invention also provides a synthesis method of the intermediate shown in the formula VI and application of the intermediate in preparation of topramezone. The reaction selectivity for preparing topramezone by using the formula VI is higher, and the whole process route is more suitable for realizing industrial production;

The invention relates to the technical field of medicinal chemistry, in particular to a novel carbamate fumarate, and a crystal form, an amorphous form and a preparation method thereof. The carbamate fumarate and the crystal form and the amorphous form thereof have high stability and solubility and low hygroscopicity, the medicinal performance is improved, the platelet aggregation resisting effect is better, the medicine effect is higher, and clinical application of the medicine is facilitated.

The application discloses a kind of chiral dihydrofuranocoumarin compounds, its synthesis method and application, belong to organic chemistry synthesis and medical field;The structure of the compound is with C3 position amino methyl substitution chiral center dihydrofuranocoumarin as skeleton, its synthesis method is: at room temperature, copper salt and chiral ligand (L) are dissolved in organic solvent and stirred, then 4-ethynyl cyclic carbamic acid ester (I), 4-hydroxycoumarin (II) are sequentially added, after stirring reaction is completed, direct separation and purification are obtained;The compound provided by the application can be efficiently converted into other novel furanocoumarin compounds by simple reaction, and has good potential application value in antitumor drug research;The synthesis method of the application has the advantages of novelty, simple operation, mild reaction condition, good substrate universality, high yield, high stereoselectivity and the like.

The invention discloses a method for detecting components of a 1, 4-bis (4-phenoxy benzoyl) benzene reaction solution by high performance liquid chromatography, which belongs to the technical field of analysis and detection methods, and the set chromatographic analysis conditions are as follows: separation by adopting a C18 chromatographic column subjected to end capping treatment, detection by adopting a diode array detector, and detection by adopting a chromatographic column subjected to end capping treatment. The contents of paraphthaloyl chloride, diphenyl ether, 1, 4-bis (4-phenoxybenzoyl) benzene (EKKE), EKKE ortho-isomer, 4-(4-phenoxybenzoyl) benzoic acid and 4-(4-phenoxybenzoyl) benzoate are simultaneously determined by using a single-point external standard method, and a determination method is provided for central control analysis and reaction endpoint judgment in a synthesis process of the 1, 4-bis (4-phenoxybenzoyl) benzene. The method is high in separation degree; the accuracy rate of a determination result is high, and the recovery rate of each substance is within the range of 95-105%; result repeatability RSD is less than 2%, and repeatability is good.

A novel compound complex that has no side effects on a liver and is used to alleviate the toxicity of an acetaminophen (APAP) drug to the liver. The composition of the compound consists of (a) acetaminophen in a pharmaceutically effective amount and (b) a commonly-used safe and pharmaceutically acceptable excipient that can be combined with one or more of two drugs to reduce the toxicity of a drug metabolized by the hepatic enzyme CYP2E1 in the liver.The compound is selected from the following group: Tween 20, microcrystalline cellulose, dicalcium phosphate, polyoxyethylene 23 lauryl ether, saccharin, mannitol, polyoxyethylene alkyl ether, sucralose, pyrrolidone, sodium starch glycolate, S100 acrylic resin, sodium carboxymethylcellulose, polyoxyethylene polyoxyethylene, menthol, low-substituted propylcellulose hydrocarbon, pregelatinized starch, Dextrates NF hydrate, citric acid, polyoxyethylene castor oil, colloidal silicon, aliphatic polyethylene glycol monostearate ester, sorbic acid, lemon oil, hydroxypropylcellulose, sorbitol, acesulfame potassium, hypromellose phthalate, lactose monohydrate, maltodextrin, Brij 58, Brij 76, Tween 80, Tween 40, PEG 400, Peg 4000, PEG 2000, and the like, so as to reduce the side effects caused by acetaminophen on the liver.

A method for producing a carbamic acid salt, including contacting a carbon dioxide-containing mixed gas having a partial pressure of carbon dioxide of 0.001 atm or more and less than 1 atm with an amino group-containing organic compound in the presence of a base in at least one organic solvent selected from the group consisting of an organic solvent having 2 or more and 8 or less carbon atoms, and a method for producing a carbamic acid ester or a urea derivative using the carbamic acid salt.

The invention discloses a method for synthesizing 1, 3-conjugated diene carboxylate by palladium-catalyzed conjugated eneyne hydrogen esterification reaction, and belongs to the field of organic synthesis. Under the protection of nitrogen, conjugated eneyne and formic acid aryl ester are used as raw materials and react in an organic solvent system containing a palladium catalyst and a ligand to obtain the 1, 3-conjugated diene carboxylic ester. The one-step method is adopted, under the combined action of the ligand and the palladium catalyst, preparation and synthesis of the 1, 3-conjugated diene carboxylic ester with good selectivity are achieved, the system is simple, and the target product can be obtained without additional treatment. The method is easy to operate, mild in condition, wide in substrate range and good in functional group compatibility, different types of conjugated enyne show good tolerance, amplification is easy, atom economy is high, and the method is superior to a traditional synthesis method in multiple aspects.

Processes for recovering dialkyl terephthalates. The processes can include exposing a polyester composition to a first composition including one or more glycols and methanol under depolymerization conditions thereby providing one or more depolymerization products. The one or more depolymerization products can be exposed to an alcoholysis process to recover dialkyl terephthalate. Optionally, the one or more glycols and / or methanol can be recovered at the end of the alcoholysis process and re-used in subsequent processes for recovering dialkyl terephthalates.

Low viscosity urethane (meth)acrylate monomers and polymerizable resin compositions are provided to facilitate production of tough polymers with well- controlled modulus and strength.

Provided is an inkjet ink which has a colorant that is stably and highly dispersed, while having excellent ejection stability (droplet formability and droplet restorability), and which is capable of improving the texture and rubbing fastness of a printed article. An inkjet ink containing: a urethane resin having (A) a structural unit derived from a polyisocyanate, (B) a structural unit derived from a polyol, and (C) a structural unit derived from a polyamine; and an organic solvent, the polyol (B) including (B1) a polyether polyol and (B2) a diol compound having a carboxyl group and / or a carboxylic acid ester group, and the polyamine (C) including (C1) a first polyamine having two groups selected from the group consisting of an amino group, an imino group, and a hydrazide group; and (C2) a second polyamine having three or four groups selected from the group consisting of an amino group, an imino group, and a hydrazide group. The mass ratio of the organic solvent to the urethane resin (mass of the organic solvent / mass of the urethane resin) is 1.0 or more.

The present application relates to the technical field of cyclohexane dicarboxylic acid ester preparation, in particular to a catalyst for hydrogenation, a preparation method and application thereof, and a method for hydrogenation of phthalic acid ester. The NH3-TPD main desorption peak position of the catalyst is 170-205 DEG C, the catalyst comprises a carrier and active elements and auxiliary elements supported on the carrier, the active elements are selected from Ru, and the auxiliary elements are selected from one or more of Pd, K, Mg, B, Cs, Zn and Ca. The catalyst provided by the present application is used for hydrogenation of phthalic acid ester to prepare cyclohexane dicarboxylic acid ester, can inhibit the generation of ester exchange or etherification by-products, improve the total selectivity of the target product, and at the same time, retain certain weak acid sites, which is beneficial to realize high dispersion of active metals and improve the conversion rate of raw materials.

The invention relates to a novel compound containing an N-methyl piperazine ethanol carbamate structure and application of the novel compound.

The invention discloses a method for synthesizing a phthalide compound with high selectivity under a biological compatibility condition. According to the method, a thiol compound and a 2-formyl benzoate compound are taken as raw materials, coupling is efficiently and rapidly realized in a PBS buffer solution under the action of potassium carbonate, and a phthalide product is generated. The reaction has the advantages of high yield and high reaction speed, shows excellent chemical selectivity on cysteine sulfydryl, and can effectively distinguish other nucleophilic amino acids. The method disclosed by the invention is wide in substrate applicability, simple and convenient in steps, low in cost, mild and green in conditions and good in functional group compatibility, and provides an efficient, safe and practical new way for construction of a linker of an antibody-coupled drug (ADC) and modification of phthalide active molecules.

Provided is a hydrogenation method of a phthalate-based compound. According to the present invention, after hydrogenation of the phthalate-based compound, a reaction product is stably decompressed to separate and recover unreacted hydrogen, thereby improving stability and economic efficiency of the process.

This bile acid adsorbing agent composed of silica particles, to which an organosilicon compound represented by general formula (1) is bonded, has the advantage that water-absorption swelling does not occur.(In formula (1), R1, R2, and R3 each independently represent a hydrogen atom, a C1-C20 alkyl group, a vinyl group, a phenyl group, or a benzyl group, and R4 represents a group represented by general formula (2), provided that R1 and R3 may be bonded to each other to form a benzene ring.)(In formula (2), A represents a linear or branched divalent linking group which may contain a heteroatom, a urethane bond, a urea bond, a thiourethane bond, and / or a thiourea bond, R5's each independently represent a C1-C10 alkyl group or a C6-C10 aryl group, R6's each independently represent a C1-C10 alkyl group or a C6-C10 aryl group, and n represents an integer of 1-3.).

This invention belongs to the field of antibacterial materials technology, specifically relating to a urethane quaternary ammonium salt, its preparation method, and its application. The preparation method includes the following steps: reacting a compound containing a -NH-COO- group with a haloalkane under the action of a catalyst to undergo a quaternization reaction, thereby obtaining the urethane quaternary ammonium salt. The preparation method of this invention is simple, low in cost, and the obtained quaternary ammonium salt antibacterial agent exhibits good antibacterial properties.

A process for preparing a compound of formula (I), or a pharmaceutically or a cosmetically acceptable salt thereof, or a stereoisomer of any of them, wherein: R′ is selected from the group consisting of H, (C1-C6)-alkyl, and (C3-C6)-cycloalkyl; R1, R2, R4, R5, R6, R7, R9, and R10 are a radical independently selected from the group consisting of H, hydroxy, amino, (C1-C6)-alkyl, (C1-C6)-alkoxy, (C1-C6)-alkylamino, and (C1-C6)-dialkylamino; and R3, and R3 are independently selected from the group consisting of (C1-C6)-alkyl, (C1-C6)-alkoxy, hydroxy, amino, (C1-C6)-alkylamino, and (C1-C6)-dialkylamino. The process includes a beta-elimination reaction of the corresponding alkyl halide precursor in the presence of DBU and an appropriate solvent.

The invention discloses a novel 3-formyl-2-methyl-4-(methylthio) benzoate compound as shown in a general formula VI, wherein R is an ester group, carboxylic acid, amide or cyano group. The invention also provides a synthesis method of the intermediate shown in the formula VI and application of the intermediate in preparation of topramezone. The reaction selectivity for preparing topramezone by using the formula VI is higher, and the whole process route is more suitable for realizing industrial production;

A method for synthesizing an aluminium-fluoride complex obtainable by reacting together: a salt made of aluminium(III) and counterions of aluminium(III) other than chloride(I), and a fluoride anion; or a chelate bearing molecule precomplexed with aluminium(III), obtained from treating the chelate bearing molecule with a salt made of aluminium(III) and counterions of aluminium(III) other than chloride(I), and a fluoride anion; the fluoride being [19F]fluoride or radioactive [18F]fluoride; wherein the counterions of aluminium(III) other than chloride are selected from bromide, iodide, nitrate, phosphate, sulfate, sulphonate, hydroxide, any anionic salt of natural and non-natural amino acids, 2,4-pentanedionate, 8-hydroxyquinoline, acetate, acrylate, ascorbate, aspartate, benzenesulfonate, benzoate, besylate, bitartrate, camphorsulfonate, citrate, decanoate, esylate, fumarate, gentisate, gluconate, glutamate, glutarate, glycinate dihydroxide, glycolate, hexanoate, hydroxynaphthoate, isethionate, lactate, lactobionate, malate, maleate, malonate, mandelate, mesylate, methylsulfate, methylsulfonate, mucate, napsylate, octanoate, oleate, oxalate, pamoate, pantothenate, phthalate, polygalacturonate, propionate, salicylate, stearate, succinate, tartrate, teoclate, toluenesulfonate, trifluoroacetate, trifluoromethanesulfonate, and any combination thereof.

The invention provides a biopolymer production method and system based on green methanol synthesis, and belongs to the technical field of biopolymers. The method comprises the following steps: carrying out synthesis reaction on hydrogen prepared by wind power electrolyzed water and CO2-rich synthesis gas generated by biomass gasification to generate green methanol; converting the prepared green methanol into formic acid through an electrocatalytic oxidation reaction; and carrying out polymerization reaction on the prepared formic acid and polyol under the action of a catalyst to generate the polyurethane biopolymer. Renewable energy sources such as wind power and biomass resources are used as initial energy sources and carbon sources, the carbon element in the production process mainly comes from carbon dioxide captured by biomass, cyclic utilization of the carbon resources is achieved, and dependence of traditional chemical engineering on fossil fuel is avoided. The conversion efficiency of biomass carbon elements and the utilization rate of raw materials are remarkably improved through pure oxygen pressurized biomass gasification and a technology for synthesizing methanol from CO2-rich synthesis gas.

A formulated polyol composition includes a polyol mixture that include a Novolac-initiated polyether and at least one other polyether, formic acid, a urethane catalyst and a surfactant having the empirical formula MD10-200DR 2-50M, where each M is R(CH3)2Si-O1 / 2- where R is hydrocarbyl having up to 10 carbon atoms, each D is -O1 / 2-Si(CH3)2-O1 / 2-, and each DR is where PE is a hydroxyl-terminated poly(ethylene oxide) consisting of 6 to 50 oxyethylene groups. This formulated polyol composition is surprisingly storage-stable. It is useful for making polyurethane foams, in particular laminated panels in a discontinuous process.

The purpose of the present invention is to provide: an active energy ray-curable composition capable of forming a cured coating film and a cured layer having weather resistance and chemical resistance and excellent appearance; a laminate having the cured layer; and a method for producing the laminate. The present invention relates to an active energy ray-curable composition characterized by containing a compound (A) containing a chain hydrocarbon group having 2-12 carbon atoms and two (meth) acryloyloxy groups, and a compound having an isocyanurate bond or an urea formate bond.

The present invention provides a chlorovinyl resin plasticizer composition capable of imparting excellent plasticization and cold resistance to a chlorovinyl resin plastisol, and excellent non-leaching properties. Specifically, the chlorovinyl resin plasticizer composition contains an aliphatic diester (A) of an aliphatic dicarboxylic acid having 2 to 12 carbon atoms and an aliphatic monoalcohol having 4 to 18 carbon atoms, an aromatic diester (B) of an aromatic monocarboxylic acid having 6 to 12 carbon atoms and a diol having 2 to 12 carbon atoms, and a phthalic acid ester (C), and satisfies aliphatic diester (A): aromatic diester (B) = 65:35 to 95:5 (mass ratio), and satisfies (aliphatic diester (A) + aromatic diester (B)): phthalic acid ester (C) = 5:95 to 35:65 (mass ratio).

The invention belongs to the technical field of organic synthesis, and particularly relates to a synthesis method of 2-cyano-5-bromopyridine, which comprises the following steps: synthesizing 5-bromo-2-picolinic acid by using 2, 5-dibromopyridine as an initial raw material; synthesizing tert-butyl (5-bromopyridine-2-formyl) carbamic acid ester by virtue of a one-step method; the method comprises the following steps: synthesizing 5-bromo-2-pyridinecarboxamide; the method comprises the following steps: synthesizing 2-cyano-5-bromopyridine; compared with the prior art, the synthetic method of the 2-cyano-5-bromopyridine, disclosed by the invention, has the advantages of high safety, high yield, high purity of the obtained product, low cost and environmental friendliness.