51 results about "Formic Acid Esters" patented technology

Provided herein are methods for preparing crystalline forms of (R)-5-carbamoylpyridin-3-yl-2-methyl-4-(3-(trifluoromethoxy)benzyl)piperazine-1-carboxylate.

The invention relates to the technical field of medicinal chemistry, in particular to a novel carbamate fumarate, and a crystal form, an amorphous form and a preparation method thereof. The carbamate fumarate and the crystal form and the amorphous form thereof have high stability and solubility and low hygroscopicity, the medicinal performance is improved, the platelet aggregation resisting effect is better, the medicine effect is higher, and clinical application of the medicine is facilitated.

A method for producing a carbamic acid salt, including contacting a carbon dioxide-containing mixed gas having a partial pressure of carbon dioxide of 0.001 atm or more and less than 1 atm with an amino group-containing organic compound in the presence of a base in at least one organic solvent selected from the group consisting of an organic solvent having 2 or more and 8 or less carbon atoms, and a method for producing a carbamic acid ester or a urea derivative using the carbamic acid salt.

Processes for recovering dialkyl terephthalates. The processes can include exposing a polyester composition to a first composition including one or more glycols and methanol under depolymerization conditions thereby providing one or more depolymerization products. The one or more depolymerization products can be exposed to an alcoholysis process to recover dialkyl terephthalate. Optionally, the one or more glycols and / or methanol can be recovered at the end of the alcoholysis process and re-used in subsequent processes for recovering dialkyl terephthalates.

Provided is an inkjet ink which has a colorant that is stably and highly dispersed, while having excellent ejection stability (droplet formability and droplet restorability), and which is capable of improving the texture and rubbing fastness of a printed article. An inkjet ink containing: a urethane resin having (A) a structural unit derived from a polyisocyanate, (B) a structural unit derived from a polyol, and (C) a structural unit derived from a polyamine; and an organic solvent, the polyol (B) including (B1) a polyether polyol and (B2) a diol compound having a carboxyl group and / or a carboxylic acid ester group, and the polyamine (C) including (C1) a first polyamine having two groups selected from the group consisting of an amino group, an imino group, and a hydrazide group; and (C2) a second polyamine having three or four groups selected from the group consisting of an amino group, an imino group, and a hydrazide group. The mass ratio of the organic solvent to the urethane resin (mass of the organic solvent / mass of the urethane resin) is 1.0 or more.

The present application relates to the technical field of cyclohexane dicarboxylic acid ester preparation, in particular to a catalyst for hydrogenation, a preparation method and application thereof, and a method for hydrogenation of phthalic acid ester. The NH3-TPD main desorption peak position of the catalyst is 170-205 DEG C, the catalyst comprises a carrier and active elements and auxiliary elements supported on the carrier, the active elements are selected from Ru, and the auxiliary elements are selected from one or more of Pd, K, Mg, B, Cs, Zn and Ca. The catalyst provided by the present application is used for hydrogenation of phthalic acid ester to prepare cyclohexane dicarboxylic acid ester, can inhibit the generation of ester exchange or etherification by-products, improve the total selectivity of the target product, and at the same time, retain certain weak acid sites, which is beneficial to realize high dispersion of active metals and improve the conversion rate of raw materials.

The invention relates to a novel compound containing an N-methyl piperazine ethanol carbamate structure and application of the novel compound.

The invention discloses a method for synthesizing a phthalide compound with high selectivity under a biological compatibility condition. According to the method, a thiol compound and a 2-formyl benzoate compound are taken as raw materials, coupling is efficiently and rapidly realized in a PBS buffer solution under the action of potassium carbonate, and a phthalide product is generated. The reaction has the advantages of high yield and high reaction speed, shows excellent chemical selectivity on cysteine sulfydryl, and can effectively distinguish other nucleophilic amino acids. The method disclosed by the invention is wide in substrate applicability, simple and convenient in steps, low in cost, mild and green in conditions and good in functional group compatibility, and provides an efficient, safe and practical new way for construction of a linker of an antibody-coupled drug (ADC) and modification of phthalide active molecules.

Provided is a hydrogenation method of a phthalate-based compound. According to the present invention, after hydrogenation of the phthalate-based compound, a reaction product is stably decompressed to separate and recover unreacted hydrogen, thereby improving stability and economic efficiency of the process.

This bile acid adsorbing agent composed of silica particles, to which an organosilicon compound represented by general formula (1) is bonded, has the advantage that water-absorption swelling does not occur.(In formula (1), R1, R2, and R3 each independently represent a hydrogen atom, a C1-C20 alkyl group, a vinyl group, a phenyl group, or a benzyl group, and R4 represents a group represented by general formula (2), provided that R1 and R3 may be bonded to each other to form a benzene ring.)(In formula (2), A represents a linear or branched divalent linking group which may contain a heteroatom, a urethane bond, a urea bond, a thiourethane bond, and / or a thiourea bond, R5's each independently represent a C1-C10 alkyl group or a C6-C10 aryl group, R6's each independently represent a C1-C10 alkyl group or a C6-C10 aryl group, and n represents an integer of 1-3.).

This invention belongs to the field of antibacterial materials technology, specifically relating to a urethane quaternary ammonium salt, its preparation method, and its application. The preparation method includes the following steps: reacting a compound containing a -NH-COO- group with a haloalkane under the action of a catalyst to undergo a quaternization reaction, thereby obtaining the urethane quaternary ammonium salt. The preparation method of this invention is simple, low in cost, and the obtained quaternary ammonium salt antibacterial agent exhibits good antibacterial properties.

A process for preparing a compound of formula (I), or a pharmaceutically or a cosmetically acceptable salt thereof, or a stereoisomer of any of them, wherein: R′ is selected from the group consisting of H, (C1-C6)-alkyl, and (C3-C6)-cycloalkyl; R1, R2, R4, R5, R6, R7, R9, and R10 are a radical independently selected from the group consisting of H, hydroxy, amino, (C1-C6)-alkyl, (C1-C6)-alkoxy, (C1-C6)-alkylamino, and (C1-C6)-dialkylamino; and R3, and R3 are independently selected from the group consisting of (C1-C6)-alkyl, (C1-C6)-alkoxy, hydroxy, amino, (C1-C6)-alkylamino, and (C1-C6)-dialkylamino. The process includes a beta-elimination reaction of the corresponding alkyl halide precursor in the presence of DBU and an appropriate solvent.

A method for synthesizing an aluminium-fluoride complex obtainable by reacting together: a salt made of aluminium(III) and counterions of aluminium(III) other than chloride(I), and a fluoride anion; or a chelate bearing molecule precomplexed with aluminium(III), obtained from treating the chelate bearing molecule with a salt made of aluminium(III) and counterions of aluminium(III) other than chloride(I), and a fluoride anion; the fluoride being [19F]fluoride or radioactive [18F]fluoride; wherein the counterions of aluminium(III) other than chloride are selected from bromide, iodide, nitrate, phosphate, sulfate, sulphonate, hydroxide, any anionic salt of natural and non-natural amino acids, 2,4-pentanedionate, 8-hydroxyquinoline, acetate, acrylate, ascorbate, aspartate, benzenesulfonate, benzoate, besylate, bitartrate, camphorsulfonate, citrate, decanoate, esylate, fumarate, gentisate, gluconate, glutamate, glutarate, glycinate dihydroxide, glycolate, hexanoate, hydroxynaphthoate, isethionate, lactate, lactobionate, malate, maleate, malonate, mandelate, mesylate, methylsulfate, methylsulfonate, mucate, napsylate, octanoate, oleate, oxalate, pamoate, pantothenate, phthalate, polygalacturonate, propionate, salicylate, stearate, succinate, tartrate, teoclate, toluenesulfonate, trifluoroacetate, trifluoromethanesulfonate, and any combination thereof.

The invention provides a biopolymer production method and system based on green methanol synthesis, and belongs to the technical field of biopolymers. The method comprises the following steps: carrying out synthesis reaction on hydrogen prepared by wind power electrolyzed water and CO2-rich synthesis gas generated by biomass gasification to generate green methanol; converting the prepared green methanol into formic acid through an electrocatalytic oxidation reaction; and carrying out polymerization reaction on the prepared formic acid and polyol under the action of a catalyst to generate the polyurethane biopolymer. Renewable energy sources such as wind power and biomass resources are used as initial energy sources and carbon sources, the carbon element in the production process mainly comes from carbon dioxide captured by biomass, cyclic utilization of the carbon resources is achieved, and dependence of traditional chemical engineering on fossil fuel is avoided. The conversion efficiency of biomass carbon elements and the utilization rate of raw materials are remarkably improved through pure oxygen pressurized biomass gasification and a technology for synthesizing methanol from CO2-rich synthesis gas.

A formulated polyol composition includes a polyol mixture that include a Novolac-initiated polyether and at least one other polyether, formic acid, a urethane catalyst and a surfactant having the empirical formula MD10-200DR 2-50M, where each M is R(CH3)2Si-O1 / 2- where R is hydrocarbyl having up to 10 carbon atoms, each D is -O1 / 2-Si(CH3)2-O1 / 2-, and each DR is where PE is a hydroxyl-terminated poly(ethylene oxide) consisting of 6 to 50 oxyethylene groups. This formulated polyol composition is surprisingly storage-stable. It is useful for making polyurethane foams, in particular laminated panels in a discontinuous process.

The present invention provides a chlorovinyl resin plasticizer composition capable of imparting excellent plasticization and cold resistance to a chlorovinyl resin plastisol, and excellent non-leaching properties. Specifically, the chlorovinyl resin plasticizer composition contains an aliphatic diester (A) of an aliphatic dicarboxylic acid having 2 to 12 carbon atoms and an aliphatic monoalcohol having 4 to 18 carbon atoms, an aromatic diester (B) of an aromatic monocarboxylic acid having 6 to 12 carbon atoms and a diol having 2 to 12 carbon atoms, and a phthalic acid ester (C), and satisfies aliphatic diester (A): aromatic diester (B) = 65:35 to 95:5 (mass ratio), and satisfies (aliphatic diester (A) + aromatic diester (B)): phthalic acid ester (C) = 5:95 to 35:65 (mass ratio).

The invention belongs to the technical field of organic synthesis, and particularly relates to a synthesis method of 2-cyano-5-bromopyridine, which comprises the following steps: synthesizing 5-bromo-2-picolinic acid by using 2, 5-dibromopyridine as an initial raw material; synthesizing tert-butyl (5-bromopyridine-2-formyl) carbamic acid ester by virtue of a one-step method; the method comprises the following steps: synthesizing 5-bromo-2-pyridinecarboxamide; the method comprises the following steps: synthesizing 2-cyano-5-bromopyridine; compared with the prior art, the synthetic method of the 2-cyano-5-bromopyridine, disclosed by the invention, has the advantages of high safety, high yield, high purity of the obtained product, low cost and environmental friendliness.

The objective is to provide a method for producing 1,2,4-oxadiazole-5(4H)-one derivatives that have pest control properties, which offers excellent yield and is advantageous for industrial-scale production. [Solution] We have discovered a method for producing 1,2,4-oxadiazole-5(4H)-one derivatives in high yield and on an industrial scale by reacting hydroxyimidamide derivatives with halogenated carbamate compounds in the presence of a base selected from carbonates, hydroxides, metal alkoxides, and metal hydrides.

Selective etchant compositions for reducing foam and related methods are provided herein. The composition may comprise a phosphoric acid; an inhibitor; and 0.01% to 5% by weight of a defoaming agent based on a total weight of the composition. The defoaming agent may comprise at least one of an alkyl carbamate compound, a bicarbonate compound, a sulfuric acid compound, or any combination thereof.

The invention discloses a coupling reaction of palladium-catalyzed secondary propargyl alcohol benzoate and sulfonamide to realize high-selectivity synthesis of 2-amido-substituted conjugated diene, and the method is suitable for coupling of a series of functionalized propargyl alcohol benzoate and sulfonamide. In addition, later-stage functional modification of complex small molecule drugs can be achieved through the method, a new method is provided for synthesis of sulfonamide compounds containing conjugated diene structures, and the method has important application prospects.

The application belongs to the technical field of high polymer materials, and particularly relates to a synthesis process of 2,3,6,7-naphthalene tetracarboxylic dianhydride. The steps are as follows: alpha,alpha,alpha',alpha',4,5-hexabromo-o-xylene is reacted with 2-(triphenylphosphoranyl) butanedioic acid dialkyl ester in an organic solvent in the presence of an acid-binding agent to obtain 6,7-dibromo-2,3-naphthalene dicarboxylate; the 6,7-dibromo-2,3-naphthalene dicarboxylate is reacted with a cyanation reagent to obtain 6,7-dicyano-2,3-naphthalene dicarboxylate; the 6,7-dicyano-2,3-naphthalene dicarboxylate is hydrolyzed in an alkaline aqueous solution, and after the reaction is completed, acidification is performed to obtain 2,3,6,7-naphthalene tetracarboxylic acid; and the 2,3,6,7-naphthalene tetracarboxylic acid is dehydrated in an acid anhydride environment to obtain 2,3,6,7-naphthalene tetracarboxylate dianhydride. The application has the advantages that raw and auxiliary materials are easy to obtain and low in cost, is suitable for mass industrial production, the synthesis process avoids harsh environments such as high temperature and high pressure, the conversion rate is high, the product quality is stable, and high-purity products can be obtained.

This invention belongs to the field of compound synthesis technology, specifically relating to a diarylguanidine derivative with anti-lymphoma function, its preparation method, and its application. The chemical name of this diarylguanidine derivative is 3-ethyl-5-methyl-(E)-4-(2-chlorophenyl)-6-methyl-2-((2-(2-(3-phenoxyphenyl)-3-phenylguanidinyl)ethoxy)methyl)-1,4-dihydropyridine-3,5-dicarboxylic acid ester. The preparation method includes step 1: reacting phenol and 4-bromonitrobenzene in DMF solution to obtain 4-nitrodiphenyl ether compounds; step 2: placing the 4-nitrodiphenyl ether compounds in an iron-containing ethanol solution to obtain 4-aminodiphenyl ether compounds; step 3: placing the 4-aminodiphenyl ether compounds and phenyl thioisocyanate in tetrahydrofuran solution to react and obtain 1-(4-phenoxyphenyl)-3-phenylurea compounds; and step 4: reacting the 1-(4-phenoxyphenyl)-3-phenylurea compounds with amlodipine under light irradiation to obtain the target compound. The product of this invention is intended for use in the preparation of anti-lymphoma drugs.

The invention relates to a preparation method of a rafenasin intermediate and rafenasin. The preparation method of the rafenasin intermediate (compound III) comprises the step of carrying out substitution reaction on piperidine-4-yl [1, 1-biphenyl]-2-carbamate (compound I) serving as a raw material and a compound II to obtain the compound III: in the compound II, X is halogen such as chlorine, bromine or iodine. The preparation method of the rafenasin intermediate is simple in reaction principle, few in by-products and simple in post-treatment, and the prepared intermediate is relatively high in yield and relatively good in purity.

The invention relates to the technical field of chemical detection, in particular to an ion mobility spectrometry system and method for detecting phthalate. Comprising a light ion source, an ion migration tube, an ion gate, an ion receiving electrode, a sample thermal precipitation device, a desorption solvent generating device and a doped reagent generating device, the ion migration tube is a hollow columnar cavity, the light ion source and the ion receiving electrode are arranged at the two ends of the cavity, and the ion gate is arranged in the cavity to form an ionization area and a migration area. A sample gas inlet of the ionization area is communicated with the sample thermal precipitation device, the desorption solvent generating device and the purging gas source; and a drift gas inlet formed in the migration area is connected with a doped reagent generating device and a drift gas source. According to the method, gas-phase solvent extraction, high-temperature thermal desorption and three-body clustering proton transfer reaction are combined, and accurate determination of trace phthalic acid ester in a complex matrix is realized in a rapid sample introduction analysis process without sample pretreatment.

A process for the production of dimethyl succinate and 1,4-butanediol comprising a 1,4-butanediol production process comprising a first esterification section and a hydrogenolysis section; and a dimet