112 results about "Formic Acid Esters" patented technology

Mixed metal metal-organic frameworks (MM-MOFs) of copper-1,3,5-benzenetricarboxylate (BTC), M-Cu-BTC, wherein M is Zn(II), Ni(II), Co(II), and / or Fe(II) may be made using post-synthetic exchange (PSE) with metal ions. Such MM-MOFs may be used in H2 storage, especially Ni(II) and Co(II) MM-MOFs. Selected metal exchanged materials can provide gravimetric H2 uptake around 1.63 wt. % for Zn—Cu-BTC, around 1.61 wt. % for Ni—Cu-BTC, around 1.63 wt. % for Fe—Cu-BTC, and around 1.12 wt. % for Co—Cu-BTC.

A method for making the benzoate salt of 4-[5-[(3S)-3-aminopyrrolidine-1-carbonyl]-2-[2-fluoro-4-(2-hydroxy-2-methyl-propyl)phenyl]-2-fluoro-benzonitrile, designated compound (A), and methods for using compound (A) are provided.

Provided herein are methods for preparing crystalline forms of (R)-5-carbamoylpyridin-3-yl-2-methyl-4-(3-(trifluoromethoxy)benzyl)piperazine-1-carboxylate.

A method for synthesizing 4,4'-biphenyldicarboxylate compounds, which belongs to the field of organic synthesis. It solves the problems of complex process route, high risk, heavy pollution and high cost in the preparation of existing 4,4'-biphenyldicarboxylate compounds. Method: First, heat and react organic titanium with 4,4'-biphenyldicarboxylic acid to obtain a crude product; Second, wash and centrifugally separate the crude product, and collect the precipitate; Third, wash and filter the precipitate, and collect the filtrate; Fourth, sequentially concentrate, crystallize, filter, wash and dry the filtrate. The invention is used for the synthesis of 4,4'-biphenyldicarboxylate compounds.

The invention discloses a novel 3-formyl-2-methyl-4-(methylthio) benzoate compound as shown in a general formula VI, wherein R is an ester group, carboxylic acid, amide or cyano group. The invention also provides a synthesis method of the intermediate shown in the formula VI and application of the intermediate in preparation of topramezone. The reaction selectivity for preparing topramezone by using the formula VI is higher, and the whole process route is more suitable for realizing industrial production;

The invention relates to the technical field of medicinal chemistry, in particular to a novel carbamate fumarate, and a crystal form, an amorphous form and a preparation method thereof. The carbamate fumarate and the crystal form and the amorphous form thereof have high stability and solubility and low hygroscopicity, the medicinal performance is improved, the platelet aggregation resisting effect is better, the medicine effect is higher, and clinical application of the medicine is facilitated.

The application discloses a kind of chiral dihydrofuranocoumarin compounds, its synthesis method and application, belong to organic chemistry synthesis and medical field;The structure of the compound is with C3 position amino methyl substitution chiral center dihydrofuranocoumarin as skeleton, its synthesis method is: at room temperature, copper salt and chiral ligand (L) are dissolved in organic solvent and stirred, then 4-ethynyl cyclic carbamic acid ester (I), 4-hydroxycoumarin (II) are sequentially added, after stirring reaction is completed, direct separation and purification are obtained;The compound provided by the application can be efficiently converted into other novel furanocoumarin compounds by simple reaction, and has good potential application value in antitumor drug research;The synthesis method of the application has the advantages of novelty, simple operation, mild reaction condition, good substrate universality, high yield, high stereoselectivity and the like.

The invention discloses a method for detecting components of a 1, 4-bis (4-phenoxy benzoyl) benzene reaction solution by high performance liquid chromatography, which belongs to the technical field of analysis and detection methods, and the set chromatographic analysis conditions are as follows: separation by adopting a C18 chromatographic column subjected to end capping treatment, detection by adopting a diode array detector, and detection by adopting a chromatographic column subjected to end capping treatment. The contents of paraphthaloyl chloride, diphenyl ether, 1, 4-bis (4-phenoxybenzoyl) benzene (EKKE), EKKE ortho-isomer, 4-(4-phenoxybenzoyl) benzoic acid and 4-(4-phenoxybenzoyl) benzoate are simultaneously determined by using a single-point external standard method, and a determination method is provided for central control analysis and reaction endpoint judgment in a synthesis process of the 1, 4-bis (4-phenoxybenzoyl) benzene. The method is high in separation degree; the accuracy rate of a determination result is high, and the recovery rate of each substance is within the range of 95-105%; result repeatability RSD is less than 2%, and repeatability is good.

A novel compound complex that has no side effects on a liver and is used to alleviate the toxicity of an acetaminophen (APAP) drug to the liver. The composition of the compound consists of (a) acetaminophen in a pharmaceutically effective amount and (b) a commonly-used safe and pharmaceutically acceptable excipient that can be combined with one or more of two drugs to reduce the toxicity of a drug metabolized by the hepatic enzyme CYP2E1 in the liver.The compound is selected from the following group: Tween 20, microcrystalline cellulose, dicalcium phosphate, polyoxyethylene 23 lauryl ether, saccharin, mannitol, polyoxyethylene alkyl ether, sucralose, pyrrolidone, sodium starch glycolate, S100 acrylic resin, sodium carboxymethylcellulose, polyoxyethylene polyoxyethylene, menthol, low-substituted propylcellulose hydrocarbon, pregelatinized starch, Dextrates NF hydrate, citric acid, polyoxyethylene castor oil, colloidal silicon, aliphatic polyethylene glycol monostearate ester, sorbic acid, lemon oil, hydroxypropylcellulose, sorbitol, acesulfame potassium, hypromellose phthalate, lactose monohydrate, maltodextrin, Brij 58, Brij 76, Tween 80, Tween 40, PEG 400, Peg 4000, PEG 2000, and the like, so as to reduce the side effects caused by acetaminophen on the liver.

A method for producing a carbamic acid salt, including contacting a carbon dioxide-containing mixed gas having a partial pressure of carbon dioxide of 0.001 atm or more and less than 1 atm with an amino group-containing organic compound in the presence of a base in at least one organic solvent selected from the group consisting of an organic solvent having 2 or more and 8 or less carbon atoms, and a method for producing a carbamic acid ester or a urea derivative using the carbamic acid salt.

The invention is applicable to the technical field of organic chemistry, and provides a copper-titanium-containing oxygen cluster catalyst and application thereof in synthesis of cyclic carbamate, a preparation method of the copper-titanium-containing oxygen cluster catalyst comprises the following steps: adding ligands into an alcohol solvent, stirring and mixing, the ligands being phenylphosphoric acid, nicotinic acid and triphenylphosphine; adding a copper source, and stirring to uniformly mix; adding a titanium source, and stirring to uniformly mix to obtain a reaction precursor mixture; and placing the sealed reaction precursor mixture in a drying oven for heating reaction to obtain a reaction mixture, cooling the reaction mixture to obtain a yellow crystal, washing, drying, and grinding to obtain yellow powder. The copper-containing titanium oxygen cluster with accurate atoms is prepared in a solvothermal mode and is applied to catalysis of carbon dioxide and propargylamine at normal temperature and normal pressure to directly synthesize the cyclic carbamate compound, copper sites are fully exposed through the copper-containing titanium oxygen cluster with the accurate atoms, meanwhile, adsorption of reactants can be enhanced through coordination of triphenylphosphine, and therefore the cyclic carbamate compound is obtained. The activation energy of the reaction is reduced.

To provide a fluorine-containing acrylic composition capable of giving excellent anti-fouling property and abrasion resistance onto a surface of a hardened product layer by adding to an active energy ray-curable composition, and having stable solubility to the active energy ray-curable composition.SOLUTION: A fluorine-containing acrylic compound includes: (A) a fluorine-containing acrylic compound having a fluoropolyether as a main chain, a trifluoromethyl group at one terminal of a molecular chain, a (meth)acrylic group at the other terminal, and two or more bonds selected from the group consisting of a carboxylic acid ester bond, a sulfonic acid ester bond, an amide bond, an urethane bond, and an urea bond in one molecule, (provided that a silicon atom is not contained in molecule); and (B) a fluorine-containing acrylic compound having a fluoropolyether as a main chain, two or more (meth)acrylic groups at both terminals of a molecular chain, and 4 to 10 (meth)acrylic groups in one molecule on an average, where 1 to 400 pts.mass of the component (A) is included to 100 pts.mass of (B).SELECTED DRAWING: None

The invention discloses a method for synthesizing 1, 3-conjugated diene carboxylate by palladium-catalyzed conjugated eneyne hydrogen esterification reaction, and belongs to the field of organic synthesis. Under the protection of nitrogen, conjugated eneyne and formic acid aryl ester are used as raw materials and react in an organic solvent system containing a palladium catalyst and a ligand to obtain the 1, 3-conjugated diene carboxylic ester. The one-step method is adopted, under the combined action of the ligand and the palladium catalyst, preparation and synthesis of the 1, 3-conjugated diene carboxylic ester with good selectivity are achieved, the system is simple, and the target product can be obtained without additional treatment. The method is easy to operate, mild in condition, wide in substrate range and good in functional group compatibility, different types of conjugated enyne show good tolerance, amplification is easy, atom economy is high, and the method is superior to a traditional synthesis method in multiple aspects.

Processes for recovering dialkyl terephthalates. The processes can include exposing a polyester composition to a first composition including one or more glycols and methanol under depolymerization conditions thereby providing one or more depolymerization products. The one or more depolymerization products can be exposed to an alcoholysis process to recover dialkyl terephthalate. Optionally, the one or more glycols and / or methanol can be recovered at the end of the alcoholysis process and re-used in subsequent processes for recovering dialkyl terephthalates.

Low viscosity urethane (meth)acrylate monomers and polymerizable resin compositions are provided to facilitate production of tough polymers with well- controlled modulus and strength.

Provided is an inkjet ink which has a colorant that is stably and highly dispersed, while having excellent ejection stability (droplet formability and droplet restorability), and which is capable of improving the texture and rubbing fastness of a printed article. An inkjet ink containing: a urethane resin having (A) a structural unit derived from a polyisocyanate, (B) a structural unit derived from a polyol, and (C) a structural unit derived from a polyamine; and an organic solvent, the polyol (B) including (B1) a polyether polyol and (B2) a diol compound having a carboxyl group and / or a carboxylic acid ester group, and the polyamine (C) including (C1) a first polyamine having two groups selected from the group consisting of an amino group, an imino group, and a hydrazide group; and (C2) a second polyamine having three or four groups selected from the group consisting of an amino group, an imino group, and a hydrazide group. The mass ratio of the organic solvent to the urethane resin (mass of the organic solvent / mass of the urethane resin) is 1.0 or more.

The present application relates to the technical field of cyclohexane dicarboxylic acid ester preparation, in particular to a catalyst for hydrogenation, a preparation method and application thereof, and a method for hydrogenation of phthalic acid ester. The NH3-TPD main desorption peak position of the catalyst is 170-205 DEG C, the catalyst comprises a carrier and active elements and auxiliary elements supported on the carrier, the active elements are selected from Ru, and the auxiliary elements are selected from one or more of Pd, K, Mg, B, Cs, Zn and Ca. The catalyst provided by the present application is used for hydrogenation of phthalic acid ester to prepare cyclohexane dicarboxylic acid ester, can inhibit the generation of ester exchange or etherification by-products, improve the total selectivity of the target product, and at the same time, retain certain weak acid sites, which is beneficial to realize high dispersion of active metals and improve the conversion rate of raw materials.

The invention relates to a novel compound containing an N-methyl piperazine ethanol carbamate structure and application of the novel compound.

The invention discloses a method for synthesizing a phthalide compound with high selectivity under a biological compatibility condition. According to the method, a thiol compound and a 2-formyl benzoate compound are taken as raw materials, coupling is efficiently and rapidly realized in a PBS buffer solution under the action of potassium carbonate, and a phthalide product is generated. The reaction has the advantages of high yield and high reaction speed, shows excellent chemical selectivity on cysteine sulfydryl, and can effectively distinguish other nucleophilic amino acids. The method disclosed by the invention is wide in substrate applicability, simple and convenient in steps, low in cost, mild and green in conditions and good in functional group compatibility, and provides an efficient, safe and practical new way for construction of a linker of an antibody-coupled drug (ADC) and modification of phthalide active molecules.

Provided is a hydrogenation method of a phthalate-based compound. According to the present invention, after hydrogenation of the phthalate-based compound, a reaction product is stably decompressed to separate and recover unreacted hydrogen, thereby improving stability and economic efficiency of the process.

This bile acid adsorbing agent composed of silica particles, to which an organosilicon compound represented by general formula (1) is bonded, has the advantage that water-absorption swelling does not occur.(In formula (1), R1, R2, and R3 each independently represent a hydrogen atom, a C1-C20 alkyl group, a vinyl group, a phenyl group, or a benzyl group, and R4 represents a group represented by general formula (2), provided that R1 and R3 may be bonded to each other to form a benzene ring.)(In formula (2), A represents a linear or branched divalent linking group which may contain a heteroatom, a urethane bond, a urea bond, a thiourethane bond, and / or a thiourea bond, R5's each independently represent a C1-C10 alkyl group or a C6-C10 aryl group, R6's each independently represent a C1-C10 alkyl group or a C6-C10 aryl group, and n represents an integer of 1-3.).

The invention belongs to the technical field of carbon dioxide absorption, and particularly relates to an alcohol amine-based eutectic solvent as well as a preparation method and application thereof. The alcohol amine-based eutectic solvent provided by the invention comprises a hydrogen bond acceptor and a hydrogen bond donor, the hydrogen bond receptor comprises a phosphino compound; the hydrogen bond donor comprises tertiary alcohol amine and secondary alcohol amine. In the invention, the phosphino compound as a hydrogen bond acceptor is mainly used for forming a hydrogen bond network with a hydrogen bond donor to promote the absorption of carbon dioxide; tertiary alcohol amine and secondary alcohol amine as hydrogen bond donors are substances mainly absorbing carbon dioxide, and secondary alcohol amine can react with carbon dioxide to generate carbamate, so that the absorption efficiency of carbon dioxide is improved.

This invention belongs to the field of antibacterial materials technology, specifically relating to a urethane quaternary ammonium salt, its preparation method, and its application. The preparation method includes the following steps: reacting a compound containing a -NH-COO- group with a haloalkane under the action of a catalyst to undergo a quaternization reaction, thereby obtaining the urethane quaternary ammonium salt. The preparation method of this invention is simple, low in cost, and the obtained quaternary ammonium salt antibacterial agent exhibits good antibacterial properties.

A process for preparing a compound of formula (I), or a pharmaceutically or a cosmetically acceptable salt thereof, or a stereoisomer of any of them, wherein: R′ is selected from the group consisting of H, (C1-C6)-alkyl, and (C3-C6)-cycloalkyl; R1, R2, R4, R5, R6, R7, R9, and R10 are a radical independently selected from the group consisting of H, hydroxy, amino, (C1-C6)-alkyl, (C1-C6)-alkoxy, (C1-C6)-alkylamino, and (C1-C6)-dialkylamino; and R3, and R3 are independently selected from the group consisting of (C1-C6)-alkyl, (C1-C6)-alkoxy, hydroxy, amino, (C1-C6)-alkylamino, and (C1-C6)-dialkylamino. The process includes a beta-elimination reaction of the corresponding alkyl halide precursor in the presence of DBU and an appropriate solvent.

The invention discloses a novel 3-formyl-2-methyl-4-(methylthio) benzoate compound as shown in a general formula VI, wherein R is an ester group, carboxylic acid, amide or cyano group. The invention also provides a synthesis method of the intermediate shown in the formula VI and application of the intermediate in preparation of topramezone. The reaction selectivity for preparing topramezone by using the formula VI is higher, and the whole process route is more suitable for realizing industrial production;

The present invention provides a method for preparing optically pure 2-methylpiperidin-5-amine. Using racemic 6-methyl-3-piperidinecarboxylate as a raw material, after reacting with a chiral acid for resolution, an optically pure intermediate of formula III is obtained. Then, through alkalization, amino protection, amidation, and Hofmann rearrangement reactions, optically pure 2-methylpiperidin-5-amine, an important intermediate for synthesizing the drug ritlecitinib, is finally obtained in high yield and high optical purity. The raw materials of the present invention are cheap and easily available, and the conditions of the synthesis route are mild, making it easy to carry out large-scale industrial production.