231 results about "Formic Acid Esters" patented technology

The invention relates to a preparation method for synthesizing an apremilast intermediate. The preparation method comprises the following steps of: carrying out condensation reaction on 3-ethoxyl-4-methoxyl-benzoate and dimethyl sulfone under an alkaline condition to generate 2-(3-ethoxy-4-methoxyphenyl)-1-methylsulfonyl acetone; reacting the compound II and chiral amine in the presence of an acidic catalyst to obtain 1-N-substituted amino-1-(3-ethoxyl-4-methoxyl) phenyl-2-methylsulfonyl ethylene (III), and directly hydrogenating the obtained compound III in the presence of a hydrogenation catalyst without separating the compound III to obtain a product (S)-1-(3-ethoxyl-4-methoxyl) phenyl-2-methanesulfonyl ethylamine (I), namely the apremilast intermediate, wherein the apremilast intermediate can be further prepared into N-acetyl L-leucinate. The invention also provides a preparation method of apremilast. The preparation method disclosed by the invention has the advantages of simple process flow, safety, environmental friendliness and low cost and is favorable to clean industrialized production.

The UV-curable aqueous coating composition is characterized by using a UV-curable aqueous emulsion obtained by urethane reaction with a mixture including a poly-carbonate polyol or polyester polyol; an isocyanate compound; a urethane-reactive carboxylic acid; a UV-curable acrylic oligomer having 2 to 9 functional acrylate groups; a UV-curable acrylic monomer; and a urethane-reactive acrylate without an organic solvent. The aqueous composition provides good environmental acceptability and satisfactory film properties comparable to those of the prior oily UV-curable coating composition and, therefore, it is useful for coating various plastics.

The present invention discloses nanometer metal catalyst catalyzed formic acid ester synthesizing process, in which alcohol is catalyzed for caronylation reaction in the presence of nanometer metal catalyst and CO. The nanometer metal catalyst with particle size of 1-10 nm is prepared through mixing metal salt and macromolecular stabilizer, dispersing in liquid medium and reducing with reductant. The nanometer metal catalyst has the following advantages: capacity of realizing 3D free rotation, excellent low temperature activity capable of catalyzing formic acid ester synthesis at 60-200 deg.c, high conversion efficiency and high selectivity of formic acid ester, stable performance, environment friendship, etc. The nanometer metal catalyst catalyzed formic acid ester synthesizing process of the present invention has broad application foreground.

The invention relates to a wetting and dispersing agent that can be produced by carrying out step (1): wherein a) an organic polymer containing primary and/or secondary amino groups and h) at least one branched polyhydroxymonocarboxylic acid comprising, in addition to a carboxyl group, at least two hydroxy groups, one of which is not bound to the main chain of the molecule, are reacted by condensation reactions, forming amide linkages; and step (2): wherein at least some of the hydroxy groups of the hydroxy-functional reaction product obtained in step (1) are reacted with at least one organic monoisocyanate, forming urethane linkages.

The invention discloses a carbamate mercaptan epoxy curing agent as well as a preparation method and application thereof. According to the preparation method, sulfhydryl pentacyclic carbonate and polyamine are taken as raw materials, and the carbamate mercaptan epoxy curing agent is prepared by one-step open-loop reaction. The carbamate mercaptan epoxy curing agent prepared by the preparation method disclosed by the invention is a novel mercaptan compound with a carbamate structure. By utilizing the carbamate mercaptan epoxy curing agent prepared by the preparation method disclosed by the invention, the flexibility and the mechanical properties of the curing agent are effectively increased.

The invention discloses a cationic type gemini fluorinated surfactant based on perfluorinated nonene and perfluorinated hexene and a preparation method of the cationic type gemini fluorinated surfactant. The preparation method comprises the following steps of: with the perfluorinated nonene or perfluorinated hexene as a raw material, condensing the perfluorinated nonene or perfluorinated hexene with p-hydroxybenzoic acid, and carrying out chlorination on a matter obtained after condensation and thionyl chloride to prepare perfluorinated alkene oxyl benzoyl chloride; condensing the perfluorinated alkene oxyl benzoyl chloride without separation with 2-dimethylamino ethanol, 3-dimethylamino propanol, 2-dimethylamino ethylamine and 3-dimethylamino propylamine to obtain perfluorinated alkene oxyl benzoate or perfluorinated alkene oxyl benzamide with tertiary amine at an alkanol part or amine part; and finally, condensing the perfluorinated alkene oxyl benzoate or perfluorinated alkene oxyl benzamide with 1,2-dihaloethane, 1,3-dihalopropane, 1,4-dichlorobutane, 1,5-dichloropentane or 3-oxa-1,5-dichloropentane to prepare a quaternary ammonium gemini fluorinated surfactant. The synthesized compound is high in surface activity and is low in critical micelle concentration, has the characteristics of simpleness in synthesization, low cost and the like and has good application prospect.

An embodiment of the present invention provides a method for improving the tensile strength of foundry cores and molds. More particularly, an embodiment of the present invention provides an improved binder for foundry cores and molds that include a fluoride bearing acid in combination with an inorganic silicon compound. Alternately, the improved binder may include a fluoride bearing acid in combination with a boron compound. In a preferred embodiment, a modified part 1 binder component includes a combination of hydrofluoric acid and an inorganic silicon compound.

The invention discloses a hydrogen peroxide detecting fluorescent probe ACR, and belongs to the technical field of analytical chemistry. The hydrogen peroxide detecting fluorescent probe uses a rhodamine derivative as a parent and 2-azide methyl aromatic formic acid ester as a switch, and the chemical structural formula of the hydrogen peroxide detecting fluorescent probe is shown in the specification. The hydrogen peroxide detecting fluorescent probe is simple to synthesize and easy to use, can be specifically reacted with hydrogen peroxide to release fluorescence, and has good hydrogen peroxide selectivity, and in the hydrogen peroxide detection process in the presence of other related oxides, the hydrogen peroxide detecting fluorescent probe has good anti-interference performance, and can detect hydrogen peroxide in living cells.

The present invention is to provide a process for simply producing an optically active 3-hydroxypropionic ester derivative useful as a medicament intermediate from an inexpensive material. More specifically, the present invention is directed to a process for producing an optically active 3-hydroxypropionic ester derivative comprising reacting an acetic ester derivative available at low cost with abase and a formic ester, thereby converting the acetic ester derivative into a 2-formylacetic ester derivative, and thereafter, stereospecifically reducing the formyl group of the derivative by use of an enzymatic source capable of stereoselectively reducing the formyl group of the derivative.

The invention relates to the technical field of chemical pesticide test, and particularly relates to a method for testing carbofuran in carbamic acid ester pesticides, in particular to a method for testing trace carbofuran. With flour, zinc meso-tetraphenylporphine solution and phosphate buffer with the pH value of 6.5 to 7.25 as materials, the method respectively prepares zinc meso-tetraphenylporphine-plant esterase compound solution and sample mixed solution, then respectively tests the absorption spectrum curves of the zinc meso-tetraphenylporphine-plant esterase compound solution and the sample mixed solution on light waves with the wavelength of 300nm to 750nm, and compares the two tested spectrum curves; if the two spectrum curves are identical, then N, N-dimethylformamide cleaner sample to be tested does not contain carbofuran, or the content of carbofuran exceeds the test limit of the method; and if the two spectrum curves are not identical, then the sample to be tested contains carbofuran. The test cost of the method is low, the method is applicable to a wide range of regions, the precision, repeatability and stability of the test result are high, field tests can be carried out as well, the method is easy to operate, and moreover, the affection of the environment on the test result is little.

The invention discloses a preparation method of an intermediate compound (R)-tert-butyl (1-((1,1'-diphenyl)-4-yl)-3-hydroxypropane-2-yl) carbamate. The preparation method is represented as the formulashown in the description. According to the preparation method, the steps are simple and short, the reaction yield is increased, reaction conditions are mild, most of the intermediates obtained in thereaction process are not required to be purified and can be subjected to the next reaction directly, large-batch synthesis is facilitated, chiral amine with stereospecificity is efficiently synthesized with aminotransferase, and the preparation method is more suitable for industrial production.

Novel potentiating steroid carbamates having the general formula (I) ST-OCONR1R2(I) wherein ST is a steroid or steroid derivative, of the structure (II) optionally containing double bonds and additional oxygen substituents; the carbamate moiety OCONR1R2 has lipophilic properties and is selected from N,N-dibutylcarbamate, N-(3-morpholin-4-yl-propyl)-carbamate, 4-benzyl-piperazine-1-carboxylic acid ester, N-(3-dibutylamino-propyl)-carbamate, N,N-dipropyl-carbamate, N-hexyl-carbamate, N-(1-benzyl-piperidine-4-yl)-carbamate, N-cyclohexylmethyl-carbamate, N-butyl-N-ethyl-carbamate, N-benzyl-carbamate, N-(3-dibenzazepin-1-yl-propyl)-N-methyl-carbamate, N-naphtalen-1-yl-methyl-carbamate, N-diphenylmethyl-carbamate, N,N-dibenzyl-carbamate, 3,4-dihydro-1H-isoquinoline-2-carboxylic acid ester, N,N-dipentyl-carbamate, N,N-diisobutyl-carbamate and N,N-bis-(4-fluoro-benzyl)-carbamate; and pharmaceutically acceptable salts thereof, in combination with radiation therapy and one or more cytotoxic drugs, optionally together with a pharmaceutically acceptable carrier and, if desired, other pharmacologically acceptable agents.

The invention discloses p-nitrophenoxy betulin (28) formyl ester and betulin derivatives synthesized therefrom, and a preparation method and an application thereof, and belongs to the technical fieldof pharmaceutical chemical. Four derivatives are synthesized with betulin as a matrix, that is to say, the tail end of a structure of the betulin is modified, a carbonacylation agent nitrophenyl chloroformate is introduced to a C-28 site, p-nitrophenoxy betulin (28) formyl ester is generated, and based on the p-nitrophenoxy betulin (28) formyl ester, four kinds of groups having biological activityand functionality are introduced. Specifically, with introduction of a structure of aminoethyl alcohol, the solubility is improved; with introduction of an N-amino morpholine group having a lysosomepositioning action and a triphenylphosphine active group having mitochondria targeted positioning, the product targetedly acts on cell organelles, the bioavailability is improved, and the higher biological activity is played; with introduction of a p-aminophenol structure, the synthesized compounds have certain antioxidant effects, and certain pharmacological activities are played by regulating the balance of redox in cells.

Addition compound which is suitable as wetting agent and dispersant and can be obtained by reaction of A) polyepoxides with B) at least one aliphatic and/or araliphatic primary amine of the general formula (I) H2N-R, where R = alkyl, cycloalkyl, aryl or aralkyl and the primary amine can bear further functional groups selected from among -OH, tertiary amine or carboxyl, and subsequent addition C) of at least one modified isocyanate of the general formula (IIa) and/or (IIb), where R = alkyl, cycloalkyl, aryl or aralkyl, R and R are each, independently of one another, H, alkyl or aryl, X = alkylene, cycloalkylene and/or aralkylene, Y = alkylene and/or cycloalkylene and n and m are independent of one another and the sum n+m is >= 2, to form a urethane.