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Transdermal absorption preparation

A preparation and absorption promotion technology, applied in the fields of novel percutaneous absorption promotion compositions and percutaneous absorption preparations, can solve problems such as unpleasant use touch, lack of sufficient effect, damage to drug stability and the like

Inactive Publication Date: 2005-09-14
HISAMITSU PHARM CO INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, these transdermal absorption enhancers do not show sufficient effects and are not necessarily effective for all drugs
In addition, some transdermal absorption enhancers, even if they show a percutaneous absorption promoting effect, have an unpleasant smell or are sticky when formulated, have an unpleasant feeling in use, and strongly irritate the skin
In addition, some percutaneous absorption enhancers have poor stability or damage the stability of drugs

Method used

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  • Transdermal absorption preparation
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Examples

Experimental program
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Effect test

Embodiment 1

[0043] Propylene glycol monocaprylate, polyoxyethylene (2) lauryl ether, and propylene glycol were mixed in a weight ratio of 1:1:8 to obtain a transdermal absorption-promoting composition. 1 part by weight of loperamide hydrochloride was dissolved in 99 parts by weight of the percutaneous absorption-promoting composition to prepare a homogeneous solution.

Embodiment 2

[0055] 1 part by weight of lidocaine was dissolved in 10 parts by weight of propylene glycol. Add and dissolve 4 parts by weight of propylene glycol monocaprylate, 4 parts by weight of polyoxyethylene (2) lauryl ether, 5 parts by weight of sorbitan sesquioleate and 4 parts by weight of paraffin wax in the solution. Then, 1.5 parts by weight of light silica and 70.5 parts by weight of white petrolatum were added, thereby preparing an ointment.

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PUM

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Abstract

A transdermal absorption promotion composition comprising the following components (a), (b), and (c) and a transdermal absorption preparation comprising the following components (a), (b), (c), and (d) are disclosed. (a) propylene glycol (b) a polyol fatty acid ester (c) lauromacrogol (d) a drug component The transdermal absorption promotion composition and transdermal absorption preparation not only exhibit an excellent transdermal absorption promotion effect, but also exhibit superior skin-permeability, even if a drug having a relatively high lipophilic property and poor transdermal absorbability is used, exhibit a favorable feeling of use, and are safe and stable.

Description

technical field [0001] The present invention relates to a novel transdermal absorption-promoting composition and a transdermal absorption preparation, more specifically, to a transdermal absorption-promoting composition capable of promoting the transdermal absorption of a compound (drug) with relatively high lipophilic physiological activity, It also relates to a percutaneous absorption preparation containing the percutaneous absorption-promoting composition and a drug. Background technique [0002] As the method of administration to a patient, oral administration, transdermal administration, injection administration, etc. may be used. When administered orally, the bioavailability of some drugs may be reduced due to first-pass effects in the liver, and some drugs may have adverse effects on the gastrointestinal tract. In addition, depending on the clinical state of the patient, oral administration may sometimes be difficult. On the other hand, injection administration not ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/06A61K9/08A61K9/12A61K9/70A61K47/10A61K47/14
CPCA61K47/10A61K9/0014A61K47/14A61P1/12A61P23/02A61K9/08A61K9/70A61K47/34
Inventor 鸣井隆大道克裕冈田实仓住敏明
Owner HISAMITSU PHARM CO INC
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