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New use of globe artichoke stem-leaf extract

A technology of thistle stem and leaf extract, which is applied in the field of new application of artichoke stem and leaf extract, can solve the problems that have not existed before, and achieve the effects of convenient preparation, high safety and huge economic benefits

Inactive Publication Date: 2017-06-13
HUAQIAO UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no report on its application in inflammation, chronic alcoholic liver injury and non-alcoholic fatty liver

Method used

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  • New use of globe artichoke stem-leaf extract
  • New use of globe artichoke stem-leaf extract
  • New use of globe artichoke stem-leaf extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0037] Preparation of artichoke stem and leaf extract: Artichoke stem and leaf were provided by Hunan Huimei Agricultural Development Co., Ltd.;

[0038] (1) Material pre-treatment: artichoke stems and leaves→washing with water→drying at 60°C→crushing→passing through a 40-60 mesh sieve→artichoke powder.

[0039] (2) Extraction: put 800kg of artichoke powder into a 3T multifunctional extraction tank, and use 3 times the amount (mass volume ratio) of 75-80% ethanol to reflux and extract twice, each time for 2 hours. The extract is filtered and put into the extract storage tank.

[0040] (3) Concentration: the extract is sucked into an external circulation decompression concentrator and concentrated to an extract of 20 to 25 degrees Baume (thermal measurement). The accumulative time of the concentration process should not exceed 4 hours, and the temperature should not exceed 60°C.

[0041] (4) Drying: Spray-dry the extract to obtain dry powder.

[0042] (5) Crushing, mixing, a...

experiment example

[0044] The artichoke stem and leaf extract of the present invention exerts anti-inflammation and prevents chronic alcoholic liver injury by regulating the TLR4 / NF-κB signaling pathway through the rat chronic alcoholic liver injury model and the rat non-alcoholic fatty liver model. and nonalcoholic fatty liver disease.

[0045] 1. Experimental materials

[0046] 1.1 Experimental animals

[0047]96 clean grade Sprague-Dawley rats, male, 8 weeks old, weighing 220±5g, were provided by Shanghai Slack Experimental Animal Co., Ltd. Certificate number: 20070000579702, license number: SCXK (Lu) 2012-2002. Before the experiment, the rats were adaptively fed for 7 days (temperature 22±2° C., relative humidity 60±5%), and all rats had free access to liquid feed and drinking water.

[0048] 1.2 Experimental reagents and drugs

[0049] Lieber-DeCarli alcoholic liquid feed (18% protein calories, 36% alcohol calories, 11% other carbohydrate calories, 35% fat calories) and Lieber-DeCarli n...

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Abstract

The invention discloses new use of a globe artichoke stem-leaf extract. The globe artichoke stem-leaf extract has the efficacies of resisting inflammation and preventing and treating chronic alcoholic liver injury and non-alcoholic fatty liver disease by decreasing the expression quantity of TLR4, NF-kappaB, IL-1beta, IL-6 and IL-8. The globe artichoke stem-leaf extract disclosed by the invention can play roles of multiple effects, multiple target points and multiple functions. Compared with existing oral alcohol-dispelling liver-protecting drugs, the globe artichoke stem-leaf extract has the advantages that the safety is relatively high; the globe artichoke stem-leaf extract is convenient to prepare and wide in market application prospects, can be applied to the preparation of medicines, health foods, food additives, feed additives, antioxidants and the like and has wide application prospects and huge economic benefits in the fields of processing and application.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a new application of artichoke stem and leaf extract. Background technique [0002] With the development of the economy and the improvement of people's consumption level, alcoholic liver disease (Alcohol liver disease, ALD) and non-alcoholic fatty liver disease (non-alcoholic liver disease, NAFLD) have become common and prevalent liver diseases in the world, constituting the world's incidence rate and one of the leading causes of mortality. ALD patients can develop alcoholic steatohepatitis (ASH), NAFLD patients can develop non-alcoholic steatohepatitis (NASH), and both ASH and NASH can further develop into liver fibrosis, liver cirrhosis, and finally It develops into liver cancer, and each stage can also exist at the same time. If liver disease (such as ASH, NASH) can be properly controlled in the early stage, it will be able to effectively prevent the deteriorati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61P29/00A61P1/16
Inventor 韦若帆汤须崇蔡婀娜雷廷平
Owner HUAQIAO UNIVERSITY
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