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Zhuang medicine composition with treatment effect on acute gouty arthritis, Zhuang medicine granules and preparation method of Zhuang medicine composition and Zhuang medicine granules

A technology for acute gout and therapeutic effect, applied in the field of ethnic medicine, can solve problems such as gastrointestinal reactions, skin rashes, and even renal failure, reduce the level of inflammatory cytokines, improve ankle swelling, and promote uric acid excretion. Effect

Inactive Publication Date: 2021-05-25
GUANGXI INT ZHUANG MEDICINE HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these drugs show good results in the short term, adverse reactions such as gastrointestinal reactions, skin rashes, and even renal failure can occur when used long-term

Method used

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  • Zhuang medicine composition with treatment effect on acute gouty arthritis, Zhuang medicine granules and preparation method of Zhuang medicine composition and Zhuang medicine granules
  • Zhuang medicine composition with treatment effect on acute gouty arthritis, Zhuang medicine granules and preparation method of Zhuang medicine composition and Zhuang medicine granules
  • Zhuang medicine composition with treatment effect on acute gouty arthritis, Zhuang medicine granules and preparation method of Zhuang medicine composition and Zhuang medicine granules

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preparation example Construction

[0028] The present invention also provides a preparation method of the above-mentioned Zhuang medicine composition, which is composed of the following steps: mixing the crude drug of the Zhuang medicine composition with water, soaking for 30 minutes, decocting 3 times, and concentrating the filtrate to a relative The extract with a density of 1.25-1.30 is dried under reduced pressure and then pulverized to obtain the dry cream powder of the Zhuang medicine composition; the mass ratio of the total mass of the crude drug to water is 1:12.

[0029] In the present invention, the decocting time is preferably 40 minutes each time, and the relative density of the extract is preferably the relative density at 60°C.

[0030] The present invention also provides the application of the above-mentioned Zhuang medicine composition or the Zhuang medicine composition prepared by the above-mentioned preparation method in the preparation of Zhuang medicine granules (Tongfeng Li'an Granules, TFLA...

Embodiment 1

[0037] Preparation of Tongfeng Li'an Granules:

[0038] Prescription: swollen knot wind 30g, Polygonum cuspidatum 20g, Honeysuckle vine 20g, Plantain 15g, Fenxia 15g, Xu Changqing 12g, Speranthum 12g, Licorice 6g

[0039] Soak the above eight herbs in 12 times the amount of water for 30 minutes, decoct 3 times for 40 minutes each time, filter, concentrate the filtrate to a thick paste with a relative density of 1.25-1.30 (60°C), dry the paste under reduced pressure, crush it, and pass it for 2 No. sieve to obtain dry paste powder, add dextrin and 95% ethanol according to the ratio of dry paste powder: dextrin: 95% ethanol as 1:1:0.25, mix, granulate, dry, granulate, bag, 15g / bag, that is.

Embodiment 2

[0041] 1. Establishment of animal model of hyperuricemia complicated with acute gouty arthritis and group administration

[0042] Sixty male SD rats were housed in separate cages, fed adaptively for 1 week, and had free access to food and water. Randomly divided into: normal group, model group, positive group and Tongfeng Li'an granule low, medium and high dose groups, 10 in each group. The modeling and administration of each group were carried out at the same time. Tongfeng Li'an granule low, medium and high dose groups were given Tongfeng Li'an granule 4.5, 9, 18g / (kg.d) by intragastric administration respectively; mg / kg), the blank group and the model group were given 10ml / kg pure water by intragastric administration. Each group was administered by intragastric administration continuously for 14 days. Except for the blank group given pure water, the rest of the groups were intragastrically administered oxonate potassium (1.5 g / kg) + adenine (0.05 g / kg) solution 8 hours aft...

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Abstract

The invention provides a Zhuang medicine composition with a treatment effect on acute gouty arthritis, Zhuang medicine particles and a preparation method of the Zhuang medicine composition and the Zhuang medicine particles, and relates to the technical field of ethnic medicines. The Zhuang medicine composition is composed of glabrous sarcandra herb, rhizoma dioscoreae hypoglaucae, plantain herb, polygonum cuspidatum, cynanchum paniculatum, garden balsam stem, honeysuckle stem and liquorice, and clinical application results prove that the Zhuang medicine composition has the effects of clearing heat toxin, removing dampness toxin, dispelling wind toxin, relieving swelling pain, adjusting water channels, dredging long channels and fire channels, and has a remarkable curative effect on gout (gout) caused by wind-damp heat toxin. The Zhuang medicine composition and the Zhuang medicine granules based on the Zhuang medicine composition have very good curative effects on arthralgia, redness and swelling, scorching heat, unfavorable flexion and extension, blood uric acid increase, tophus and the like, and particularly, the Zhuang medicine composition and the Zhuang medicine granules based on the Zhuang medicine composition can be used for treating gouty arthritis induced by MSU crystals, and have the characteristics of multiple targets and low toxicity.

Description

technical field [0001] The invention belongs to the technical field of ethnic medicines, and in particular relates to a strong medicine composition, strong medicine granules and a preparation method thereof, which have a therapeutic effect on acute gouty arthritis. Background technique [0002] Gout is caused by the disorder of purine metabolism, increased uric acid synthesis and / or decreased excretion. The clinical manifestations are hyperuricemia and deposition of monosodium urate in bones, joints, kidneys and subcutaneous parts, causing acute and chronic inflammation and A metabolic disease of tissue damage. [0003] Evidence from prospective epidemiological studies has identified dietary factors (animal purines, alcohol, and fructose), obesity, metabolic syndrome, hypertension, diuretics, and chronic kidney disease as clinically relevant risk factors for hyperuricemia and gout. Currently, there are no effective drugs for gout patients, although researchers have conducte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61K9/16A61P19/02A61P19/06
CPCA61K9/1652A61K36/185A61K36/27A61K36/355A61K36/47A61K36/484A61K36/68A61K36/704A61K36/8945A61P19/02A61P19/06A61K2300/00
Inventor 赵湘培黎丽滕红丽黄国东
Owner GUANGXI INT ZHUANG MEDICINE HOSPITAL
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