Rhizoma corydalis decumbentis extract, preparation method thereof, medicament composition containing the rhizoma corydalis decumbentis and application thereof

A technology of total alkaloids and extracts, applied in pharmaceutical preparations, a pharmaceutical composition containing summer free of total alkaloids, its preparation, in the field of summer free of total alkaloids, can solve frequent injections of injections, inconvenient storage, To solve problems such as large doses of medicine, to achieve the effect of controllable product quality and safety, improved effectiveness, and internal quality

Inactive Publication Date: 2007-10-24
SHANGHAI INST OF PHARMA IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are still big deficiencies in the clinical application of Xia Tian Wu preparations. For example, Xia Tian Wu tablets have the disadvantages of large dosage and inconvenient storage; injections require frequent injections, which brings great inconvenience to patients.

Method used

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  • Rhizoma corydalis decumbentis extract, preparation method thereof, medicament composition containing the rhizoma corydalis decumbentis and application thereof
  • Rhizoma corydalis decumbentis extract, preparation method thereof, medicament composition containing the rhizoma corydalis decumbentis and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment 1: A kind of preparation method that does not have total alkaloid in summer

[0044] Take the dry tubers that are not available in summer, and beat them into powder to obtain medicinal powder with a particle size of 10 mesh to 60 mesh; take 200 g of medicinal powder, add 50% ammonia water as an alkalizing agent, and the dosage is 10% of the weight of the medicinal material, and mix until weakly alkaline; mix the medicinal material Put it into the extraction kettle, and heat or cool the storage tank respectively; when the extraction temperature reaches 65°C, the temperature of the analysis kettle I reaches 45°C, and the temperature of the analysis kettle II reaches 40°C, turn on the CO 2 pressurize the system through a high-pressure pump; when the pressure of the extraction kettle reaches 25Mpa, the pressure of the analysis kettle I reaches 3Mpa, and the pressure of the analysis kettle II reaches 0Mpa, keep constant temperature and pressure, and keep a constant...

Embodiment 2

[0045] Embodiment 2: A kind of preparation method that does not have total alkaloid in summer

[0046] Take the dry tubers that are not available in summer, and beat them into powder to obtain medicinal material powder with a particle size of 20 mesh to 60 mesh; take 200 g of medicinal material powder, add 15% ammonia water as an alkalizing agent, and the dosage is 70% of the weight of the medicinal material, and mix until weakly alkaline; mix the medicinal material Put it into the extraction kettle, and heat or cool the storage tank respectively; when the extraction temperature reaches 45°C, the temperature of the analysis kettle I reaches 35°C, and the temperature of the analysis kettle II reaches 30°C, turn on the CO 2 pressurize the system through a high-pressure pump; when the pressure of the extraction kettle reaches 50Mpa, the pressure of the desorption kettle I reaches 14Mpa, and the pressure of the desorption kettle II reaches 6Mpa, keep constant temperature and pressu...

Embodiment 3

[0047] Embodiment 3: A kind of preparation method that does not have total alkaloid in summer

[0048] Take the dry tubers that are not available in summer, and beat them into powder to obtain medicinal powder with a particle size of 30 mesh to 80 mesh; take 200 g of medicinal powder, add 45% ammonia water as an alkalizing agent, and the dosage is 45% of the weight of the medicinal material, and mix until weakly alkaline; mix the medicinal material Put it into the extraction kettle, and heat or cool the storage tank respectively; when the extraction temperature reaches 85°C, the temperature of the analysis kettle I reaches 70°C, and the temperature of the analysis kettle II reaches 70°C, turn on the CO 2 pressurize the system through a high-pressure pump; when the pressure of the extraction kettle reaches 20Mpa, the pressure of the analysis kettle I reaches 10Mpa, and the pressure of the analysis kettle II reaches 5Mpa, keep constant temperature and pressure, and keep a constan...

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Abstract

The invention discloses a total alkaloid extract and making method of eye drip, which comprises the following parts: opium alkaline, tetrahydropalmatine, cumic acid, alcaine palmatine, corydaline, summer alkaline and other biological alkalines. The preparing method comprises the following steps: adopting summer non as raw material; optimizing hypercritical CO2 flow to extract; collecting extract; drying; obtaining the total alkalilne extract; fitting for tablet, pill, suppository, percutaneous absorption agent, oral rapid-breaking agent, release-control agent and freeze dried.

Description

technical field [0001] The invention relates to the field of traditional Chinese herbal medicines, in particular to the total summer free alkaloids, a preparation method thereof, a pharmaceutical composition containing the total summer free alkaloids, and the application of the pharmaceutical composition in pharmaceutical preparations. Background technique [0002] Summer Wu is the dry tuber or whole herb of Corydalis decumbens (Thunb.) Pers., a plant of the genus Corydalis in the family Papaveraceae. Summer Wu is widely distributed in Jiangsu, Anhui, Zhejiang, Jiangxi, Fujian, Taiwan, Hunan and other provinces. Commonly used Chinese herbal medicine in my country has the effects of promoting blood circulation, dredging collaterals, promoting qi, and relieving pain. It is mainly used for the treatment of stroke and hemiplegia caused by high blood pressure and cerebrovascular disease, and has a good effect on rheumatoid arthritis, sciatica, and sequelae of polio. Its main acti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D471/04C07D491/12C07D491/153C07G5/00A61K31/395A61K31/44A61K36/66A61K9/20A61K9/48A61K9/02A61K9/14A61K9/19C07D221/00
Inventor 蒋爱芳杨义芳
Owner SHANGHAI INST OF PHARMA IND CO LTD
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