Traditional Chinese medicine pharmacokinetics-pharmacodynamics combined analysis method

A joint analysis and pharmacokinetics technology, applied in the direction of analytical materials, scientific instruments, material separation, etc., can solve the problems that the effects cannot be directly and continuously quantitatively measured, the research and application of PK-PD are limited, and the mechanism of action is not very clear.
CN102183608AInactive Publication Date: 2011-09-14ZHEJIANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHEJIANG UNIV
Publication Date
2011-09-14
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a traditional Chinese medicine pharmacokinetics-pharmacodynamics combined analysis method, which determines various endogenous metabolites in blood samples of a blank control group, a model group and a model treatment group by a GC-MS method, uses an abnormally-changed metabolite group of the model group as a biomarker group, uses an effect index with obvious callback of the abnormally-changed metabolite group after traditional Chinese medicine intervention as an efficacy marker group, determines the contents of various drugs in the blood samples of a model animal after single dose by a LC-MS method, draws a plasma concentration-time curve, calculates the pharmacokinetic parameters of each component; determines the amount of the endogenous efficacy marker group in the blood samples of the model animal single dose group by a GC-MS method, draws a time-effect curve, performs PK-PD combined analysis by combining with the plasma concentration-time curve and parameters. The invention reveals the efficacy substance base of traditional Chinese medicine in the treatment of cardiovascular diseases, and provides an effective method for traditional Chinese medicine pharmacokinetics-pharmacodynamics combined analysis.
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Description

technical field

[0001] The invention belongs to the field of Chinese pharmacy research, and relates to a combined pharmacokinetics-pharmacodynamics (Pharmacokinetics-Pharacodynamics, PK-PD) analysis method of traditional Chinese medicines, in particular to a combined pharmacokinetics-pharmacodynamics analysis method of traditional Chinese medicines for treating cardiovascular diseases , which can be used in the pharmacokinetics-pharmacodynamics joint study of complex traditional Chinese medicines. technical background

[0002] The combination of pharmacokinetics and pharmacodynamics can explore the effect of the body on the drug (PK) and the effect of the drug on the body at the same time, revealing the relationship between drug concentration-time-effect, so as to provide clinical safety, effective and rational drug use. Provide scientific experimental basis.

[0003] The current PK-PD combination research and its application have made some progress. However, PK-PD research...

Claims

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