This invention generally relates to a technique for degrading systemic toxins
in vivo by enhancing the
metabolic function of the lungs. Such a technique involves introducing a composition into the
lung tissue of a subject, the composition comprising at least one
enzyme known to enzymatically break down at least one
toxin systemically present in the subject's body. The provided technique enables the lungs to act as a modulated metabolic organ, thereby promoting the removal of toxins from the
systemic circulation of a subject, such as a subject suffering from a condition leading to the accumulation of toxins or endogenous metabolites, or a subject who has ingested toxic substances.