Sanicula lamelligera hance sesquiterpene extract for treating influenza

A technology of lung meridian and sesquiterpene, which is applied in the field of preparation of the effective part, can solve the problems that have not been reported in the literature, and achieve the effects of inhibiting the proliferation of influenza virus, less toxic and side effects, and reducing the dosage

Inactive Publication Date: 2011-01-05
SANJIN GROUP HUNAN SANJIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] After searching, there is no literature report on the treatment of influenza with lung meridian grass sesquiterpene extract

Method used

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  • Sanicula lamelligera hance sesquiterpene extract for treating influenza
  • Sanicula lamelligera hance sesquiterpene extract for treating influenza

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Take 100kg of lung meridian herbs, add 70% ethanol to reflux and extract twice, each time for 1 hour, add 800kg of 70% ethanol for the first time, add 600kg of 70% ethanol for the second time, filter, combine the extracts, and recover the extracts Ethanol is concentrated into a thick paste, add an appropriate amount of absolute ethanol to dissolve, mix well with the same weight of macroporous adsorption resin, add water more than 10 times the amount of absolute ethanol, stir, add to the treated macroporous adsorption resin column, First elute with 30% low-concentration ethanol until colorless, discard the 30% ethanol eluate, then elute with 90% ethanol until colorless, collect the 90% ethanol eluate, recover ethanol and concentrate Form into a thick paste with a relative density of 1.25, and dry it in vacuum to obtain a sesquiterpene extract containing 30% of total sesquiterpenes.

Embodiment 2

[0031] Take 100kg of lung meridian herbs, add 90% ethanol to reflux extraction twice, each time for 1.5 hours, add 700kg90% ethanol for the first time, add 600kg90% ethanol for the second time, filter, combine the extracts, and recover the extracts Ethanol is concentrated into a thick paste, add an appropriate amount of absolute ethanol to dissolve, mix well with the same weight of macroporous adsorption resin, add water more than 10 times the amount of absolute ethanol, stir, add to the treated macroporous adsorption resin column, First elute with 30% low-concentration ethanol to colorless, discard the 30% ethanol eluate, then elute with 80% ethanol until colorless, collect the 80% ethanol eluate, recover ethanol and concentrate Form a clear ointment with a relative density of 1.10, and spray dry to obtain a sesquiterpene extract containing 60% of total sesquiterpenes.

Embodiment 3

[0033] Take 100kg of lung meridian herbs, add 80% ethanol to reflux and extract twice, each time for 2 hours, add 800kg80% ethanol for the first time, add 600kg80% ethanol for the second time, filter, combine the extracts, and recover the extracts Ethanol is concentrated into a thick paste, add an appropriate amount of absolute ethanol to dissolve, mix well with the same weight of macroporous adsorption resin, add water more than 10 times the amount of absolute ethanol, stir, add to the treated macroporous adsorption resin column, First elute with 30% low-concentration ethanol until colorless, discard the 30% ethanol eluate, then elute with 90% ethanol until colorless, collect the 90% ethanol eluate, recover ethanol, vacuum Dry to get dry extract. Add 5 times the amount of water to the dry extract to suspend, extract 4 times with ethyl acetate, each time the amount of ethyl acetate is equal to the sample volume, combine the ethyl acetate layers, recover ethyl acetate, and vacu...

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Abstract

The invention discloses a sanicula lamelligera hance sesquiterpene extract, which is characterized in that: the total sesquiterpene content of the extract is over 30 percent. The sanicula lamelligera hance sesquiterpene extract is prepared by extracting and refining traditional Chinese medicine sanicula lamelligera hance. Pharmacodynamic and toxicologic experiments prove that the sanicula lamelligera hance sesquiterpene extract has the effects of obviously inhibiting the proliferation of influenza virus and resisting mouse influenza viral pneumonia, and has small toxic and side effects. The invention also discloses medicinal application of the sanicula lamelligera hance sesquiterpene extract.

Description

Technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to an effective part extracted from the traditional Chinese medicine Lung Meridian, and also relates to a preparation method of the effective part and its medical application. Background technique [0002] Influenza (flu) is caused by influenza virus (influenza virus) respiratory tract infection. Since it became popular in the United States in 1918 and swept the world, the loss caused by influenza to humans ranks first among infectious diseases. Among colds, 80% are influenza A H1N1. At present, influenza A (H1N1), as a viral infectious disease that seriously endangers public health, is sweeping the world and threatening human life. According to the statistics of the Ministry of Health of my country, as of January 31, 2010, 31 provinces across the country have accumulatively reported A There were 126,000 confirmed cases of H1N1 influenza, including 775 deaths. [...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/23A61P31/16A61P11/00
Inventor 周小江
Owner SANJIN GROUP HUNAN SANJIN PHARMA
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