Application of raja porosa extract in alcoholic brain damage protection medicine

An extract and alcohol-based technology, which is applied in the application field of the extract of the stingray in the protection medicine for alcohol-induced brain injury, can solve the problems that the effect of alcohol-induced brain injury has not been reported, etc.

Inactive Publication Date: 2015-12-30
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Yellow and Bohai seas are found all year round, with large output, and are important fishery catch objects. The endoskeleton is all cartilage, and the fin rays are horny fin rays. The inventor extracts the ra

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Embodiment 1: the preparation of preparation

[0011] (1) Preparation of the capsule preparation of the ray extract of the present invention

[0012] Weigh 100 mg of the ray extract prepared in the above steps, 395 mg of starch, and 5 mg of magnesium stearate, mix them uniformly, and fill them into capsules.

[0013] (2) Preparation of the ray extract tablet of the present invention

[0014] Weigh 100 mg of ray extract, 295 mg of starch, and 100 mg of lactose prepared in the above steps, mix them uniformly, granulate them by wet method, dry them, mix them with 5 mg of magnesium stearate after granulation, and press them into tablets.

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PUM

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Abstract

The invention relates to application of raja porosa extract in alcoholic brain damage protection medicine. The raja porosa extract is extracted from raja porosa cartilage and can improve the activity of SOD and GSH-PX in the brain tissue of rats with chronic alcoholism, reduce MDA and beta-EP in the brain tissue, the protection effect on the brain damage of the rats with chronic alcoholism is achieved, the raja porosa extract can be prepared into various dosage forms and can serve as an alcoholic brain damage protecting agent, and the raja porosa extract has the advantages of being remarkable in curative effect, free of side effects, low in price, safe and convenient to use.

Description

technical field [0001] The invention relates to the application of the ray extract in the protection medicine of alcoholic brain injury. Background technique [0002] Alcoholism is a state in which the central nervous system changes from excitement to inhibition caused by excessive drinking. Long-term heavy drinking can cause damage to multiple organs throughout the body, especially to the brain. Alcoholism and addiction have become a worldwide social problem that seriously endangers human health. [0003] When a large amount of alcohol accumulates in the body and exceeds the catabolic capacity of the liver, it can be directly absorbed into the blood. Alcohol is a lipophilic small molecule chemical substance that easily acts on the brain through the blood-brain barrier. It has been reported in the literature that alcoholism can cause cerebrovascular lesions to affect cerebral blood flow, resulting in changes in ischemia and hypoxia, which may be one of the mechanisms of bra...

Claims

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Application Information

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IPC IPC(8): A61K35/60A61P25/00
Inventor 高华刘坤王威于兹东刘小红石振艳
Owner QINGDAO UNIV
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