Application of dasyatis sinensis extractive to preparation of medicine for protecting alcoholic cerebral injury

An extract and alcohol-based technology, applied in the field of application of Chinese ray extract in alcohol-induced brain injury protection drugs

Inactive Publication Date: 2015-12-09
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The effect of Chinese ray extract on alcoholic brain injury has not been reported

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Embodiment 1: the preparation of preparation

[0011] (1) Preparation of Chinese ray extract capsule preparation of the present invention

[0012] Weigh 100 mg of Chinese ray extract prepared in the above steps, 395 mg of starch, and 5 mg of magnesium stearate, mix them evenly, and fill them into capsules.

[0013] (2) Preparation of Chinese ray extract tablet of the present invention

[0014] Weigh 100 mg of Chinese ray extract, 295 mg of starch, and 100 mg of lactose prepared in the above steps, mix uniformly, granulate by wet method, dry, mix with 5 mg of magnesium stearate after granulation, and press into tablets.

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PUM

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Abstract

The invention discloses application of a dasyatis sinensis extractive to preparation of a medicine for protecting alcoholic cerebral injury. The dasyatis sinensis extractive is prepared through extracting cartilage of dasyatis sinensis, can increase the activity of SOD and GSH-PX in brain tissues of rats suffering from chronic alcoholism, reduces MDA and beta-EP in the brain tissues, protects cerebral injury of rats suffering from chronic alcoholism, can be prepared into multiple dosage forms, can be used as a protective agent for alcoholic cerebral injury, and has the advantageous characteristics of being remarkable in curative effect, free of side effect, low in price, safe and convenient.

Description

technical field [0001] The invention relates to the application of a Chinese ray extract in a drug for protecting alcoholic brain damage. Background technique [0002] Alcoholism is a state in which the central nervous system changes from excitement to inhibition caused by excessive drinking. Long-term heavy drinking can cause damage to multiple organs throughout the body, especially to the brain. Alcoholism and addiction have become a worldwide social problem that seriously endangers human health. [0003] When a large amount of alcohol accumulates in the body and exceeds the catabolic capacity of the liver, it can be directly absorbed into the blood. Alcohol is a lipophilic small molecule chemical substance that easily acts on the brain through the blood-brain barrier. It has been reported in the literature that alcoholism can cause cerebrovascular lesions to affect cerebral blood flow, resulting in changes in ischemia and hypoxia, which may be one of the mechanisms of br...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/60A61P25/00
Inventor 刘坤杨俊杰高华刘占涛王威刘小红石振艳
Owner QINGDAO UNIV
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