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Application of chimaera phantasma extract in preparation of drugs for treating alcoholic brain damage

An extract, alcohol-based technology, applied in the application field of black shark extract in alcohol-induced brain injury protection medicine

Inactive Publication Date: 2016-03-09
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The effect of chimaera extract on alcoholic brain injury has not been reported

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Embodiment 1: the preparation of preparation

[0010] (1) Preparation of the capsule preparation of the black line chimaera extract of the present invention

[0011] Weigh 100 mg of chimaera extract prepared in the above steps, 395 mg of starch, and 5 mg of magnesium stearate, mix them uniformly, and fill them into capsules.

[0012] (2) Preparation of the black line chimaera extract tablet of the present invention

[0013] Weigh 100 mg of chimaera extract prepared in the above steps, 295 mg of starch, and 100 mg of lactose, mix uniformly, granulate by wet method, dry, mix with 5 mg of magnesium stearate after granulation, and press into tablets.

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PUM

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Abstract

The invention discloses an application of a chimaera phantasma extract in the preparation of drugs for treating alcoholic brain damage. The chimaera phantasma extract is extracted from soft bones of chimaera phantasma. The chimaera phantasma extract can increase the activity of SOD and GSH-PX in the brain tissues of rats, which have chronic alcoholism, at the same time, reduces MDA and beta-EP in brain tissues, and protects the damaged brain of alcohol poisoned rats. The extract can be made into a plurality of dosage forms, and can be used as a protective agent for alcoholic brain damage.

Description

technical field [0001] The invention relates to the application of an extract of chimaera to protect alcoholic brain damage. Background technique [0002] Alcoholism is a state in which the central nervous system changes from excitement to inhibition caused by excessive drinking. Long-term heavy drinking can cause damage to multiple organs throughout the body, especially to the brain. Alcoholism and addiction have become a worldwide social problem that seriously endangers human health. [0003] When a large amount of alcohol accumulates in the body and exceeds the catabolic capacity of the liver, it can be directly absorbed into the blood. Alcohol is a lipophilic small molecule chemical substance that easily acts on the brain through the blood-brain barrier. It has been reported in the literature that alcoholism can cause cerebrovascular lesions to affect cerebral blood flow, resulting in changes in ischemia and hypoxia, which may be one of the mechanisms of brain damage af...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/60A61P25/00
CPCA61K35/60A61K9/2059A61K9/4866
Inventor 石振艳刘坤高华
Owner QINGDAO UNIV
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