Application of butylphenyl phthaleine in preparing medicament for treating chronic alcoholism

A technique for alcoholism, butylphthalide, used in medicine

Inactive Publication Date: 2012-05-23
XINXIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Tricyclic antidepressants can be used to manage anxiety and depression from any cause, but because these symptoms may disappear with alcohol withdrawal, they should not be used until after alcohol withdrawal if symptoms persist

Method used

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  • Application of butylphenyl phthaleine in preparing medicament for treating chronic alcoholism
  • Application of butylphenyl phthaleine in preparing medicament for treating chronic alcoholism
  • Application of butylphenyl phthaleine in preparing medicament for treating chronic alcoholism

Examples

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Embodiment Construction

[0020] The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention. Example 1 NBP on alcohol-dependent rat hippocampus H 2 Effect of S content and NR2B expression

[0021] Ca 2+ Can make H 2 Increased production of S, especially the calcium ion / calmodulin-mediated signal transduction pathway, can rapidly regulate H 2 The generation of S. Long-term alcohol exposure experiments in vivo and in vitro showed that the expression of NR2B subunits was increased, especially in cultured hippocampal and cortical neurons. In this experiment, after NBP acts on alcohol-dependent rats, hippocampal H 2 S content, CBS activity, NR2B mRNA expression changes and withdrawal symptom score were used to study the effect of NBP on alcohol-dependent rats.

[0022] 1. Materials

[0023] 1. Main instruments and reagents

[0024] The Bio-Tek ELx800 microplate reader was provided by American Bio-Tek Company, and the PCR ampl...

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Abstract

The invention relates to a butylphenyl phthaleine, a medical salt thereof or an application of a medical compound which contains any one of the butylphenyl phthaleine and the medical salt thereof in preparing a medicament for preventing or treating chronic alcoholism. The medicament or medical compound is characterized by being efficient, harmless and free from addiction in the application of preventing or treating the chronic alcoholism.

Description

technical field [0001] The invention relates to the application of butylphthalide or its medicinal salt or a pharmaceutical composition containing any one of them in the prevention and treatment of chronic alcoholism, belonging to the field of medicine. Background technique [0002] Chronic alcoholism refers to severe central nervous system poisoning caused by long-term excessive drinking. Alcohol is ethanol, chemical formula C 2 h 5 OH, is a neurotropic substance. Since ethanol that enters the human body cannot be digested and absorbed, it will enter the brain along with the blood, destroy neuron cell membranes, weaken the central nervous system, and cause brain activity to slow down by activating inhibitory neurons and inhibiting activating neurons. A large number of nerve cells die. Excessive drinking can also lead to alcoholic coma. [0003] Chronic alcoholism, also known as alcohol dependence or addiction, is a compulsive mental state of compulsion to drink, which ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/343A61K9/48A61K9/20A61K9/19A61K9/08A61P25/32
Inventor 张瑞岭杜爱林徐春阳姜洪波李爽李文强李成长李新娟顾仁骏孟莉李晓娟苗琴邵坤陈璐侯福佳卢智敏宋亭亭张勇贾娟
Owner XINXIANG MEDICAL UNIV
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