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Medicinal composition for sobering

A composition and drug technology, which can be used in drug combinations, pharmaceutical formulations, plant raw materials, etc., and can solve problems such as complex mechanisms

Inactive Publication Date: 2012-08-15
ZHAOQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The mechanism of alcohol damage to organs is complex and has not yet been fully elucidated

Method used

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  • Medicinal composition for sobering

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment one: the preparation of pharmaceutical composition of the present invention

[0019] This example is to determine the composition of the pharmaceutical composition for sobering up alcohol according to the present invention, determine the best preparation process, carry out extraction of active ingredients of the pharmaceutical composition and preparation of preparations, and conduct animal experiments.

[0020] , drug extraction

[0021] Choose from the Chinese herbal medicines with the same source of medicine and food: kudzu root, kudzu flower, chrysanthemum, Xihuangcao, gardenia, Hovenia dulcis, kudzu root, amomum, dried ant as raw materials, respectively take microwave extraction, filtration, re-extraction, and evaporation Concentrate and dry to obtain the pharmaceutical composition of the present invention.

[0022] , drug compatibility

[0023] Orthogonal test (see Table 1) is used to comprehensively evaluate the sobering effects of different dosage...

Embodiment 2

[0029] Embodiment two: the dosage form preparation of pharmaceutical composition of the present invention

[0030] The medicament preparation method of the pharmaceutical composition of the present invention is as follows: according to the formula screened by the orthogonal test of Example 1, take the required Chinese herbal medicine for each group of formulas in proportion, add them all in a large beaker, mix, add 10 Double the amount of distilled water, microwave extraction 6 times, 3 minutes each time, filter, add 8 times the amount of distilled water to the filter residue, microwave extraction 6 times, 3 minutes each time, combine the filtrate after filtration, evaporate and concentrate to more than 65%. Dried under reduced pressure at 60°C, crushed into fine powder, sieved, and made into corresponding dosage forms according to the requirements of various dosage forms and excipients.

[0031] Can be prepared into pill types such as water pills, pasted pills, wax pills, con...

Embodiment 3

[0036] Embodiment three: the hangover test of the pharmaceutical composition of the present invention

[0037] According to the formula determined in Example 1 and the method determined in Example 2, the pharmaceutical composition of the present invention was made into an oral preparation (powder) for sobering up alcohol, which was used in the sobering up test of this example.

[0038] Acute renal failure was used as a model: several mice were randomly divided into groups of 10, male and female, fasted overnight (12h) before the test. Each group was given white wine 0.14mL / 10g body weight by intragastric administration firstly, and the mice became drunk (that is, the righting reflex disappeared) and did not wake up for 10 minutes, and acute renal failure was used as the model successfully.

[0039] Sobering up test: 40 mice were randomly divided into four groups, 10 mice in each group, half male and half male, divided into blank group: 0.14mL / 10g body weight normal saline was ad...

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Abstract

The invention relates to a medicinal composition for sobering and a relevant preparation process. The preparation process comprises the following steps of: performing microwave extraction on kudzuvine root, flos puerariae, chrysanthemum, linearstripe rabdosia herb, gardenia root, semen hoveniae and fructus amomi which serve as raw material from Chinese medicinal herbs which are homologous in medicines and food, filtering, performing the microwave extracting again, evaporating, concentrating and drying to obtain a sample. The medicinal composition has a certain sobering function, and can resist acute alcoholic liver injury, chronic alcoholism and lipid peroxidation of livers, kidneys and brains of mice, reduce the level of triglyceride, prevent the formation of fatty liver and protect livers.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a pharmaceutical composition for sobering up alcohol and a related preparation process. Background technique [0002] The World Health Organization pointed out: Alcoholism is a major public hazard in the current world. Alcoholism is very common in western countries. According to statistics, 15 to 20 million people in the world suffer from alcoholism, and 10% to 20% of them suffer from alcoholic liver disease to varying degrees. The February survival rate of patients with severe alcoholic liver disease is lower than 50%, and long-term drinking can cause damage to liver, stomach, kidney and other organs, and can cause alcoholic hepatitis and cirrhosis. Due to the changes in the lifestyle and dietary structure of Chinese residents and the increase in alcohol production in recent years, the proportion of alcoholics in the population is on the rise. According to an epidemiol...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9064A61P25/32
Inventor 李充璧余荣俊李赛男黄丽华黄寿昌邓军崔铁成李芸瑛
Owner ZHAOQING UNIV
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