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Use of Chinese goldthread total alkali in preparing medicine for treating diabetes complication

A technology for treating medicine and diabetes, which is applied in the application field of Coptis chinensis total alkaloids in the preparation of medicines for treating diabetic complications, and can solve the problems of hypoglycemia reaction, no obvious effect of diabetic vascular complications and the like

Inactive Publication Date: 2009-04-01
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although Xiaoke Pills currently on the market have an annual sales of over 100 million yuan and are the main product of Chinese patent medicines for hypoglycemia, Xiaoke Pills are a mixture of Chinese and Western medicines. Long-term and large-scale use may cause side effects of "hypoglycemia" and have adverse effects on diabetic blood vessels. Complications have no apparent effect

Method used

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  • Use of Chinese goldthread total alkali in preparing medicine for treating diabetes complication
  • Use of Chinese goldthread total alkali in preparing medicine for treating diabetes complication
  • Use of Chinese goldthread total alkali in preparing medicine for treating diabetes complication

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Example 1: Total alkaloids extracted from Coptis chinensis.

[0012] 1) Grind Coptis chinensis into coarse powder

[0013] 2) 5-10 times the amount of 60-80% ethanol to reflux extract the coarse powder of Coptis chinensis 1-3 times, 1-2h / time, filter in stages, and combine the filtrates. Concentrate under reduced pressure and dry to obtain Coptis rhizome extract.

[0014] 3) Add 5 times the amount of Coptis chinensis extract to 0.5% sulfuric acid to dissolve, filter, adjust the pH of the filtrate to 9 with milk of lime, filter, adjust the pH to 1-2 with hydrochloric acid, add sodium chloride to make the salt content reach 10%, shake Evenly, let it stand to get the total alkaloids of Coptidis rhizome. Or use the macroporous resin method to separate and purify the total alkaloids of Coptis chinensis. Drying, further formulation into oral dosage forms or injection dosage forms.

[0015] For example: oral dosage forms can be processed into granules (infusions), tablets ...

Embodiment 2

[0017] Crush the Coptidis medicinal material into coarse powder, extract the Coptidis coarse powder by reflux for 3 times with 5 times the amount of 60% ethanol, 1 hour each time, filter in stages, and combine the filtrates. Concentrate under reduced pressure and dry to obtain Coptis rhizome extract. All the other steps are the same as in Example 1 to prepare the medicine of the present invention.

Embodiment 3

[0019] Grind the Coptis rhizome into coarse powder, extract the Coptis rhizome coarse powder twice with 8 times the amount of 75% ethanol under reflux for 1.5 hours each time, filter in stages, and combine the filtrates. Concentrate under reduced pressure and dry to obtain Coptis rhizome extract. All the other steps are the same as in Example 1 to prepare the medicine of the present invention.

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Abstract

The invention relates to a drug for reducing blood glucose, regulating blood lipid and treating diabetes mellitus combined with hyperlipidemia and other chronic vascular complications and a preparation method thereof. The drug is total alkaloids which are extracted from traditional Chinese medicine golden thread. The preparation method of the drug comprises the following steps: 1) the golden thread herbal medicine is crushed into coarse powder; 2) 5-10 times of the amount of 60-80 percent ethanol is used for carrying out the reflux extraction of the golden thread coarse powder for 1-3 times by 1-2h / time, the filtration is carried out by times, and filtrates are merged. Golden thread extract is obtained by pressure reduction concentration and drying; 3) the golden thread extract is added in 5 times of the amount of 0.5 percent sulfuric acid for dissolution and filtration, the filtrates are respectively regulated to pH9 by lime milk, filtrated and respectively regulated to pH1-2 by hydrochloric acid, sodium chloride is added to allow the salt content to be 10 percent, and the total alkaloids of the golden thread are obtained by even shaking and still placement. Or the golden thread extract is used for separating and purifying the total alkaloids of the golden thread by macroporous resin method. The drying is carried out, and the total alkaloids of the golden thread are prepared into oral formulation or injection formulation. The drug has prominent efficacy for the diabetes mellitus combined with hyperlipidemia and other chronic vascular complications.

Description

[technical field] [0001] The invention relates to an application of total alkaloids (coptidis total alkaloids) extracted from coptis chinensis raw materials in the preparation of medicines for treating chronic vascular complications such as diabetes combined with hyperlipidemia, and a preparation method of coptis chinensis total alkaloids. [Background technique] [0002] Diabetes is a common endocrine and metabolic disorder, which belongs to the category of "diabetes" in traditional Chinese medicine. With the aging of the world's population, diabetes has become a common and frequently-occurring disease. According to statistics, there are currently 130 million diagnosed type II diabetes patients in the world, and more than 40 million people in my country, and the incidence rate is increasing year by year. Cardiovascular and cerebrovascular diseases cause about 80% of diabetic patients' death rate, and reduce their life expectancy by 1 / 3. Diabetic patients with elevated blood ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/718A61P3/10A61P3/06
Inventor 黄河清
Owner SUN YAT SEN UNIV
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