Medical hydroxybutyl chitosan sponge and preparation method thereof

A technology of hydroxybutyl chitosan and chitosan, applied in the fields of medicine and health, can solve the problems of easy to cause immunogenic reaction, weak tissue adhesion, easy to detach from the wound surface, etc., achieve good hemostasis, avoid toxic and side effects, The effect of promoting tissue healing

Inactive Publication Date: 2017-08-11
惠众国际医疗器械(北京)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, medical sponges prepared from gelatin and collagen materials are likely to cause immunogenic reactions when used in the human body because their raw materials are heterogeneous proteins; polyvinyl alcohol-based sponges have formaldehyde and other reactions involved in the preparation,

Method used

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  • Medical hydroxybutyl chitosan sponge and preparation method thereof
  • Medical hydroxybutyl chitosan sponge and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0029] Example 1

[0030] Step 1: Purification of Chitosan Products

[0031] Weigh a certain amount of chitosan crude product, dissolve it in 1% hydrochloric acid at a ratio of 1g:50mL, filter to remove insoluble matter, dropwise add 1mol / L sodium hydroxide solution to a slightly alkaline solution to obtain a precipitate, wash with purified water to neutrality, desalted and dehydrated with ethanol solution, and dried to obtain purified chitosan.

[0032] Step 2: Preparation of hydroxybutyl chitosan

[0033] The purified chitosan powder was dispersed in a 50% aqueous solution of sodium hydroxide or potassium hydroxide at a ratio of 1 g:10 mL for alkalization treatment, and heated for 24 hours under nitrogen protection at a temperature of 50°C. The excess lye solution was filtered off, the remaining solid was dispersed in isopropanol aqueous solution at the ratio of 1g:20mL, then a certain volume of 1,2-butylene oxide was added, reacted for 1 hour, and heated at 70°C for 18 ho...

Example Embodiment

[0043] Example 2

[0044] Step 1: Purification of Chitosan Products

[0045] Same as step 1 in Example 1.

[0046] Step 2: Preparation of hydroxybutyl chitosan

[0047] The purified chitosan powder was dispersed in a 50% sodium hydroxide or potassium hydroxide aqueous solution at a ratio of 1 g:10 mL for alkalization treatment, and heated for 24 hours under nitrogen protection at a temperature of 40°C. The excess lye solution was filtered off, the remaining solid was dispersed in isopropanol aqueous solution at the ratio of 1 g:20 mL, and then a certain volume of 1,2-butylene oxide was added, reacted for 1 hour, and heated at 60°C for 24 hours. After cooling, adjust the pH value to neutral, filter out insoluble matter, add ethanol, centrifuge, and dry to obtain a hydroxybutyl chitosan product.

[0048] Step 3: Preparation of hydroxybutyl chitosan solution

[0049] Under clean environment conditions, prepare hydroxybutyl chitosan solution, weigh the above items according to...

Example Embodiment

[0057] Example 3

[0058] Step 1: Purification of Chitosan Products

[0059] Same as step 1 in Example 1.

[0060] Step 2: Preparation of hydroxybutyl chitosan

[0061] The purified chitosan powder was dispersed in a 50% aqueous solution of sodium hydroxide or potassium hydroxide at a ratio of 1 g:10 mL for alkalization treatment, and heated for 24 hours under nitrogen protection at a temperature of 50°C. The excess lye solution was filtered off, the remaining solid was dispersed in isopropanol aqueous solution at the ratio of 1 g:20 mL, and then a certain volume of 1,2-butylene oxide was added, reacted for 1 hour, and heated at 55°C for 24 hours. After cooling, adjust the pH value to neutral, filter out insoluble matter, add ethanol, centrifuge, and dry to obtain a hydroxybutyl chitosan product.

[0062] Step 3: Preparation of hydroxybutyl chitosan solution

[0063] Under clean environment conditions, prepare hydroxybutyl chitosan solution, weigh the above items according...

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Abstract

The invention belongs to the technical field of medicine and hygiene and particularly relates to medical hydroxybutyl chitosan sponge and a preparation method thereof. The sponge is prepared from hydroxybutyl chitosan, sodium chloride, disodium hydrogen phosphate, sodium dihydrogen phosphate and a plastic agent which is one or more of glycerin and polyethylene glycol. A cross-linking agent is not needed, and the sponge has a thermal-sensitive characteristic after absorbing tissue fluid or blood, can be converted to a gel state when reaching the normal temperature of a human body, is firmly bonded with tissue, has effects of stopping bleeding, preventing adhesion and promoting tissue repair, can be combined with a sterilizing agent, growth factors and other drugs for use, and can also be applied to the fields of tissue engineering and artificial organs.

Description

technical field [0001] The invention belongs to the technical field of medicine and sanitation, and in particular relates to a hydroxybutyl chitosan sponge and a preparation method thereof. Background technique [0002] At present, in my country's medical market, a variety of medical sponge products are widely used in surgical hemostasis, cavity hemostasis and wound healing treatment. Domestic and foreign hemostatic sponge products registered in the State Food and Drug Administration of China, the main types include: polyvinyl alcohol medical sponge, polyvinyl alcohol and glycerin, collagen sponge, polyvinyl formal sponge, chitosan hemostatic sponge , Absorbent gelatin sponge, carboxymethyl chitosan sponge. Among them, medical sponges prepared from gelatin and collagen materials are likely to cause immunogenic reactions when used in the human body because their raw materials are heterogeneous proteins; polyvinyl alcohol-based sponges have formaldehyde and other reactions in...

Claims

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Application Information

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IPC IPC(8): C08B37/08C08J9/28C08L5/08A61L24/00A61L27/20A61L27/54
CPCC08J9/28A61L24/0015A61L24/08A61L27/20A61L27/54A61L2300/404A61L2300/412A61L2400/04C08B37/003C08J2305/08C08L5/08
Inventor 闫瑞国郭文广孙陆军潘海江
Owner 惠众国际医疗器械(北京)有限公司
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