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Medical hydroxybutyl chitosan sponge and preparation method thereof

A technology of hydroxybutyl chitosan and chitosan, applied in the fields of medicine and health, can solve the problems of easy to cause immunogenic reaction, weak tissue adhesion, easy to detach from the wound surface, etc., achieve good hemostasis, avoid toxic and side effects, The effect of promoting tissue healing

Inactive Publication Date: 2017-08-11
惠众国际医疗器械(北京)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, medical sponges prepared from gelatin and collagen materials are likely to cause immunogenic reactions when used in the human body because their raw materials are heterogeneous proteins; polyvinyl alcohol-based sponges have formaldehyde and other reactions involved in the preparation, and their residues will give adverse effects on the human body
Sponge made of chitosan, carboxymethyl chitosan and other materials, although its water absorption and hemostatic effect are good, but it has the disadvantage of not being firmly adhered to the tissue and easily detached from the wound.

Method used

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  • Medical hydroxybutyl chitosan sponge and preparation method thereof
  • Medical hydroxybutyl chitosan sponge and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Step 1: Chitosan product purification

[0031] Weigh a certain amount of chitosan crude product, dissolve it in 1% hydrochloric acid according to the ratio of 1g: 50mL, filter to remove insoluble matter, add dropwise 1mol / L sodium hydroxide solution until it is slightly alkaline, obtain a precipitate, wash with purified water To neutrality, use ethanol solution to desalt and dehydrate, and obtain purified chitosan after drying.

[0032] Step 2: Preparation of hydroxybutyl chitosan

[0033] Disperse the purified chitosan powder in the ratio of 1g: 10mL in 50% sodium hydroxide or potassium hydroxide aqueous solution for alkalization treatment, and heat treatment for 24 hours under nitrogen protection at a temperature of 50°C. Filter off the excess lye, disperse the remaining solids into isopropanol aqueous solution at a ratio of 1g:20mL, then add a certain volume of 1,2-epoxybutane, react for 1 hour, and heat at 70°C for 18 hours. After cooling, adjust the pH value to n...

Embodiment 2

[0044] Step 1: Chitosan product purification

[0045] Same as Step 1 in Example 1.

[0046] Step 2: Preparation of hydroxybutyl chitosan

[0047] Disperse the purified chitosan powder in the ratio of 1g: 10mL in 50% sodium hydroxide or potassium hydroxide aqueous solution for alkalization treatment, and heat treatment under nitrogen protection for 24 hours at a temperature of 40°C. Filter off the excess lye, disperse the remaining solids into isopropanol aqueous solution at a ratio of 1g:20mL, then add a certain volume of 1,2-epoxybutane, react for 1 hour, and heat at 60°C for 24 hours. After cooling, adjust the pH value to neutral, filter out the insoluble matter, add ethanol, centrifuge and dry to obtain the hydroxybutyl chitosan product.

[0048] Step 3: Preparation of hydroxybutyl chitosan solution

[0049] Under clean environment conditions, prepare hydroxybutyl chitosan solution, according to the ratio of hydroxybutyl chitosan content 100.0mg / mL, glycerin 20.0mg / mL, p...

Embodiment 3

[0058] Step 1: Chitosan product purification

[0059] Same as Step 1 in Example 1.

[0060] Step 2: Preparation of hydroxybutyl chitosan

[0061] Disperse the purified chitosan powder in the ratio of 1g: 10mL in 50% sodium hydroxide or potassium hydroxide aqueous solution for alkalization treatment, and heat treatment for 24 hours under nitrogen protection at a temperature of 50°C. Filter off the excess lye, disperse the remaining solids into isopropanol aqueous solution at a ratio of 1g:20mL, then add a certain volume of 1,2-epoxybutane, react for 1 hour, and heat at 55°C for 24 hours. After cooling, adjust the pH value to neutral, filter out the insoluble matter, add ethanol, centrifuge and dry to obtain the hydroxybutyl chitosan product.

[0062] Step 3: Preparation of hydroxybutyl chitosan solution

[0063] Under clean environment conditions, prepare hydroxybutyl chitosan solution, according to the ratio of hydroxybutyl chitosan content 50.0mg / mL, glycerin 10.0mg / mL, po...

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Abstract

The invention belongs to the technical field of medicine and hygiene and particularly relates to medical hydroxybutyl chitosan sponge and a preparation method thereof. The sponge is prepared from hydroxybutyl chitosan, sodium chloride, disodium hydrogen phosphate, sodium dihydrogen phosphate and a plastic agent which is one or more of glycerin and polyethylene glycol. A cross-linking agent is not needed, and the sponge has a thermal-sensitive characteristic after absorbing tissue fluid or blood, can be converted to a gel state when reaching the normal temperature of a human body, is firmly bonded with tissue, has effects of stopping bleeding, preventing adhesion and promoting tissue repair, can be combined with a sterilizing agent, growth factors and other drugs for use, and can also be applied to the fields of tissue engineering and artificial organs.

Description

technical field [0001] The invention belongs to the technical field of medicine and sanitation, and in particular relates to a hydroxybutyl chitosan sponge and a preparation method thereof. Background technique [0002] At present, in my country's medical market, a variety of medical sponge products are widely used in surgical hemostasis, cavity hemostasis and wound healing treatment. Domestic and foreign hemostatic sponge products registered in the State Food and Drug Administration of China, the main types include: polyvinyl alcohol medical sponge, polyvinyl alcohol and glycerin, collagen sponge, polyvinyl formal sponge, chitosan hemostatic sponge , Absorbent gelatin sponge, carboxymethyl chitosan sponge. Among them, medical sponges prepared from gelatin and collagen materials are likely to cause immunogenic reactions when used in the human body because their raw materials are heterogeneous proteins; polyvinyl alcohol-based sponges have formaldehyde and other reactions in...

Claims

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Application Information

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IPC IPC(8): C08B37/08C08J9/28C08L5/08A61L24/00A61L27/20A61L27/54
CPCC08J9/28A61L24/0015A61L24/08A61L27/20A61L27/54A61L2300/404A61L2300/412A61L2400/04C08B37/003C08J2305/08C08L5/08
Inventor 闫瑞国郭文广孙陆军潘海江
Owner 惠众国际医疗器械(北京)有限公司
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