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A bacterial cellulose-based asymmetric bilateral heterosexual biological patch and its preparation method

A technology of bacterial cellulose and bacterial cellulose film, which is applied in the field of bacterial cellulose-based asymmetric bilateral heterosexual biological patch and its preparation, can solve the problem of lack of bilateral heterosexual performance, insufficient anti-adhesion effect, poor adaptability, etc. problems, to achieve the effect of facilitating the expansion of production, easy control of sample shape and size, and low cost

Active Publication Date: 2021-03-30
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The currently used tissue patches can be divided into the following five categories according to different sources: autologous tissue repair materials, allogeneic tissue, xenogeneic biological materials, synthetic repair materials and natural materials, specifically polypropylene, polytetrafluoroethylene, Materials such as polyvinylidene fluoride, porcine pericardium, bovine pericardium and collagen, so far, these materials can replace and repair soft tissues to a certain extent after being implanted in the human body, but there are still some clinical problems such as: Insufficient adhesion effect; does not have the performance of bilateral heterosexuality, etc.
For example, the polypropylene material commonly used in hernia repair has the advantages of good biocompatibility, high mechanical strength, and the ability to promote the formation of fibrous tissue deposits. It is currently the preferred repair material for abdominal wall defects. Adhesion or even erosion of intestines and other problems
In addition, SEAMDURA artificial dura mater has good biocompatibility and can effectively prevent the leakage of cerebrospinal fluid, but the adaptability of the patch in contact with the brain tissue is poor, there is adhesion phenomenon, and it may lead to chronic fibrosis of brain tissue risks of

Method used

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  • A bacterial cellulose-based asymmetric bilateral heterosexual biological patch and its preparation method

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preparation example Construction

[0032] A preparation method of a bacterial cellulose-based asymmetric bilateral heterosexual biological patch, the preparation method comprising the steps of:

[0033] (1) slowly dehydrating the bacterial cellulose saturated with water;

[0034] (2) using femtosecond or millisecond laser drilling technology to prepare micropores of a certain density and size on the surface of the bacterial cellulose semi-dry film obtained in step (1);

[0035](3) The microporous bacterial cellulose semi-dry film obtained through step (2) adopts a vacuum end-capping method to make its side with micropores closely adhere to the mold surface by vacuuming, and then place it in a closed reaction vessel, Using high temperature and high pressure single-sided chemical vapor deposition method, the other side is modified with a long carbon chain hydrophobic modifier for unilateral anti-adhesion modification;

[0036] (4) After the reaction vessel was cooled to room temperature, the material was taken o...

Embodiment 1

[0052] The commercially available BC prepared from Acetobacter xylinum was cut into a BC sample of 4cm×4cm.

[0053] Step 1, pretreating BC with lye to obtain a bacterial cellulose film with a pH value of about 7.3;

[0054] Step 2. Place the pretreated BC membrane flat on a smooth flat plate, then place a flat plate on the BC membrane, apply a weight of 10KG on the flat plate, and press out part of the moisture in the BC membrane for 30 minutes. , and then apply a weight of 20KG on the plate for 30 minutes, and so on, until no more water flows out of the BC film, and finally place the BC film in a drying mold and dry it in vacuum at 30°C for 12 hours to obtain BC semi-dry Membrane, put it in a ziplock bag and save it for later use;

[0055] Step 3. Evenly spread the BC semi-dry film treated in step 2 on the mold, and use a carbon dioxide laser drilling machine to prepare a density of 1000 pieces / cm on one side of the surface. 2 , micropores with a diameter of 200 μm;

[00...

Embodiment 2

[0060] The commercially available BC prepared from Acetobacter xylinum was cut into a BC sample of 4cm×4cm.

[0061] Step 1, pretreating BC with lye to obtain a bacterial cellulose film with a pH value of about 7.3;

[0062] Step 2. Place the pretreated BC membrane flat on a smooth flat plate, then place a flat plate on the BC membrane, apply a weight of 10KG on the flat plate, and press out part of the moisture in the BC membrane for 30 minutes. , and then apply a weight of 20KG on the plate for 30 minutes, and so on, until no more water flows out of the BC film, and finally place the BC film in a drying mold and dry it in vacuum at 30°C for 12 hours to obtain BC semi-dry Membrane, put it in a ziplock bag and save it for later use;

[0063] Step 3. Evenly spread the BC semi-dry film treated in step 2 on the mold, and use a carbon dioxide laser drilling machine to prepare a density of 1000 pieces / cm on one side of the surface. 2 , micropores with a diameter of 100 μm;

[00...

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Abstract

The invention provides a bacterial-cellulose-based asymmetric bidirectional isomerism biological mesh and a preparation method thereof. The preparation method includes the steps that a smooth semi-drymembrane of bacterial cellulose is obtained by slow dehydration and drying, then micropores are formed in the bacterial cellulose side, then the side with the micropores is closely attached to the mold-controlled modified surface, and finally, through hydrolytic condensation deposition of a long carbon chain hydrophobic modifier on the other side under high temperature and high pressure, the biological mesh with good adhesion resistance on one side and good tissue bonding and tissue repair ability on the other side is obtained. According to the bacterial-cellulose-based asymmetric bidirectional isomerism biological mesh and the preparation method thereof, on the premise of ensuring excellent comprehensive mechanical properties and biocompatibility of the bacterial cellulose, anti-adhesionproperties are improved, the preparation method is simple, the preparation cost is relatively low, the sample shape and size are easy to control, and the bacterial-cellulose-based asymmetric bidirectional isomerism biological mesh is expected to be widely used in clinical practice; and in addition, the bacterial-cellulose-based asymmetric bidirectional isomerism biological mesh can be used for repairing hernia, dura mater, tendon, myocardium, pelvic floor and other soft tissues, and can be further used for artificial blood vessels and artificial skin and other biomedical fields.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials and provides a bacterial cellulose-based asymmetric bilateral heterosexual biological patch and a preparation method thereof. [0002] technical background [0003] As a tissue replacement material, tissue patch is mainly used for the repair of various soft tissues or the enhancement of weak tissues, and has attracted more and more attention. Currently commonly used are hernia mesh, cardiac mesh, tendon mesh and dura mater mesh. When the patch material is implanted in the body as an implantable material, it should have the following characteristics: ① It has stable biological inertia and does not cause acute and chronic inflammatory reactions; ② It is safe, non-toxic, non-carcinogenic, and does not spread diseases; ③ Tissue Good compatibility, no immune reaction; ④ has a certain degree of compactness, can prevent leakage; ⑤ good toughness, can withstand suture or bonding; It is impor...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/60A61L27/50A61L27/56A61L27/20
CPCA61L27/20A61L27/50A61L27/507A61L27/56A61L27/60A61L2400/18C08L1/02
Inventor 郑裕东杨莹莹谢亚杰高明朗
Owner UNIV OF SCI & TECH BEIJING
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