Use of ginsenoside Rb1 in preparing medicine for treating dilated cardiomyopathy

A technology of dilated cardiomyopathy and ginsenosides, which is applied in the field of medicine, can solve the problems of ginsenoside Rb1 that has not been reported, achieve high development and application value, improve the structure of intercalated discs, and reduce mitochondrial swelling.
CN101390872AActive Publication Date: 2009-03-25INST OF LAB ANIMAL SCI CHINESE ACAD OF MEDICAL SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
INST OF LAB ANIMAL SCI CHINESE ACAD OF MEDICAL SCI
Publication Date
2009-03-25

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Abstract

The invention belongs to the medicine field and provides an application of ginsenoside Rb1 in preparing medicine used for the treatment of dilated cardiomyopathy. The ginsenoside has the following functions: after long-term medicine delivery, the mortality of genetic dilated cardiomyopathy is reduced; the cardiac function of dilated cardiomyopathy is improved; the dilation of left ventricular is reduced; the myocardial cell hypertrophy and interstitial collagen hyperplasia of dilated cardiomyopathy are reduced; problems of uneven thickness of myocardial fiber, disorder arrangement, mitochondrial swelling, cristae rupture, sarcoplasmic reticulum dilation and broken intercalated disc connection found in the dilated cardiomyopathy are reduced; the expression of myocardial cell connexin Cx40 is improved; the expressions of cadherin E-cadherin and P-cadherin are improved; the expressions of fibroblast growth factors including FGF2, FGF7, FGF8 and FGF10 are enhanced. The expressions of integrin Itga8, Itgbp are reduced.
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Description

technical field

[0001] The invention belongs to the field of medicine, and in particular relates to the application of ginsenoside Rb1 as a medicine for treating dilated cardiomyopathy. Background technique

[0002] Dilated cardiomyopathy is a myocardial disease mainly characterized by ventricular dilation and impaired myocardial systolic function. The clinical manifestations are progressive heart failure, arrhythmia, thromboembolism, and even sudden death. The prognosis is extremely poor, and the 5-year survival rate Less than 50%. The typical pathological features are dilation of ventricular cavity, thinning of heart wall, and apoptosis of cardiomyocytes. The main etiology is viral myocarditis and gene mutation, accounting for 70% of the incidence of dilated cardiomyopathy.

[0003] A variety of mutated genes associated with dilated cardiomyopathy have been found in clinical studies, but most gene mutations can cause HCM and DCM at the same time, while the R141W mutation ...

Claims

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