65 results about "Myocardial disease" patented technology

The present invention relates to methods of using granulocyte colony stimulating factor (G-CSF) polypeptide, alone and in conjunction with stromal cell derived factor (SDF-1) polypeptide, to increase the mobilization of c-Kit+ stem cells in the blood, bone marrow, tissue, heart or other organs for the subsequent production of embryoid body-like cell clusters. These embryoid body-like cell clusters can be used for cell replacement therapy, for the treatment of cardiac myopathy and other diseases and disorders, and for screening agents that drive or inhibit differentiation and proliferation.

The invention relates to a medical examination and diagnosis method and instrument, in particular to a multi-dimensional electrocardio ultrasonic signal fusion computed tomography imaging system and method based on anatomical orientation. A multi-dimensional ultrasonic cardiac structure and a perfusion image technology are further integrated on the basis of a multi-dimensional electrocardiosignal imaging system and method, and a novel non-invasive platform is provided for recording and evaluating the electro-mechanical signal characteristic and myocardial perfusion characteristic of heart. The method is a unique electrocardio-mechanical function and perfusion synchronized computed tomography imaging method based on anatomical orientation, and the technology is a non-invasive imaging technology for detecting transmural cardiac electrical activity information and mechanical signals. By adopting the medical examination and diagnosis method and instrument, the diagnosis of myocardial diseases such as cardiac hypertrophy, cardiomyopathy, myocardial infarction and myocarditis, the determination of the origin of arrhythmia, and the like can be enhanced, and a brand-new diagnosis and guide treatment tool is provided for rapid real-time diagnosis of heart diseases.

The invention relates to medical examination and diagnosis methods and instruments, in particular to a multi-dimensional electrocardiosignal imaging system and method. The body surface electric potential mapping technology and the electrocardio vector technology are integrated, a new non-invasive platform is provided for recording the heart-across-myocardium electrical activity information, and in other words, a new non-invasive body surface heart-across-myocardium electrical activity information imaging method and technology which are formed by combining the vector center 0 point galvanic coupling and body surface electric potential mapping technology and are similar to satellite positioning are provided. The non-invasive electrocardio function imaging method and technology for detecting heart-across-myocardium electrocardio activity information with the dissection positioning as a basis are provided. According to the multi-dimensional electrocardiosignal imaging system and method, the arrhythmia reason can be determined, the cardiac muscle diseases such as myocardial hypertrophy, cardiomyopathy, myocardial infarction and myocarditis can be diagnosed, and a brand new diagnosis tool is provided for fast diagnosing the heat diseases in real time.

The present invention relates to a Chinese medicine for curing high blood pressure and myocardial diseases, which is prepared with 10 portions of ginseng, 20 portions of astragalus root, 10 portions of cassia twig, 10 portions of cassia barkcassia bark, 5 portions of red sage root, 15 portions of safflower, 10 portions of radix polygoni multiflori preparata, 10 portions of Chinese wolfberry, 10 portions of malaytea scurfpea fruit , 10 portions of oriental waterplantain rhizome, 10 portions of fourstamen stephania root, 10 portions of eucommia bark, 10 portions of Chinese magnoliavine fruit, 10 portions of doubleteeth pubescent angelica root, 15 portions of suberect spatholobus stem, 15 portions of Chinese taxillus twig, 10 portions of szechuan lovage rhizome, 10 portions of turmeric root-tuber, 10 portions of notoginseng, 10 portions of costus root, 10 portions of figwort root and 5 portions of liquoric root. The Chinese medicine mainly treats myocardial diseases such as coronary heart disease, angina pectoris and high blood pressure.

The invention provides a traditional Chinese medicine preparation for treating pediatric viral myocarditis. The preparation comprises raw materials of Radix Ophiopogon, therootofred-rootedsalvia, cassia twig, alliummacrostemon, rootofcommonpeony, Schisandra chinensis, pseudo-ginseng, Astragalusmongholicus, Fructus Trichosanthis, Fructus Forsythiae, Semen Platycladi, Rhizoma Atractylodis, luffa vegetable sponge, angelica, Ligusticumwallichii, curcuma zedoary, ginger processed pinellia, the root of large-flowered skullcap, polygala root, earthworm, and Radix aucklandiae. The invention aims to prepare a medicine for treating myocarditis from selected traditional Chinese medicines. The prepared medicine not only can improve the metabolism of myocardium and myocardial nutrition, protect the heart cells and improve myocardial disease resistance, but also can directly kill virus, reduce the damage of virus on myocardium, and realize combination of antivirus and overall regulation; and the medicine can reduce deputy effects caused by long-term application of Western medicine on the human body, and is an ideal medicine for treating myocarditis. In addition, the medicine prepared by the invention contains a large amount of active ingredients, employs cheap raw materials and simple preparation method, and can be widely used in clinical practice.

A surface attached cardiac function monitor and/or intervention system comprises of a cardiac support device, a cardiac function monitor device and/or intervention device. Cardiac support device is attached on an external or internal surface of a cardiac chamber and supports it. The cardiac function monitor device is connected with a biochemical and physiological sensor. The physiological and biochemical sensor transmits variations of biochemical and physiological parameters that are received by the cardiac function monitor device. The intervention device has at least one member selected from pressure intervention device, an electrical/magnetic stimulation intervention device and a medicine intervention device. This medical system of the present invention could help in diagnosis as well as treatment of the heart failure and other myocardial diseases to improve the condition of patient. It could also be helpful for the monitoring, diagnosis and treatment of diseases of lungs, kidney, liver, spleen, stomach and bladder, etc.

The present invention relates to 3,4-dihydroquinazoline derivatives as T-type calcium channel blockers and a method of preparing the same. The present invention further relates to a composition comprising the same. The composition comprising the 3,4-dihydroquinazoline derivatives of the present invention can be effectively used for preventing and treating angina pectoris, high blood pressure, myocardial disease, pain and epilepsy by blocking the T-type calcium channel.

The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of familial amyloid polyneuropathy may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of transthyretin-related hereditary amyloidosis, neurodegenerative diseases, amyloidosis, neuropathic pain, amyloid fibril formation and cardiomyopathy related diseases.

The invention relates to a labeling technique of ⁹⁹Tc^m-His10-Annexin V and the applications of the ⁹⁹Tc^m-His10-Annexin V as an imaging agent in terms of apoptosis under the condition of detecting diseases. By applying a direct labeling method, the invention utilizes SnCl₂ . 2H₂O reductant and citrate buffer to carry out ⁹⁹Tc^m labeling on His10-Annexin V. The method has the advantages of simple and convenient operation and low cost. Experiments on animals show that the injected ⁹⁹Tc^m-His10-Annexin V can clearly display the apoptosis of different tissues, such as cardiac muscle, tumor, etc., and can be applied to the diagnosis of myocardial lesions, the efficacy evaluation of tumor chemotherapy, etc.

A compound of formula (Ia) or (Ib), or a pharmaceutically acceptable salt thereof, Wherein Q, R², Ar, A and R¹ are as defined in claim 1. The claimed compounds are gap junction blockers useful for the treatment or prevention of a range of conditions including migraine, epilepsy, non-epileptic seizures, brain injury (including stroke, intracranial haemorrhage and trauma induced), pain, neurodegenerative disease or cardiovascular disease including myocardial infarction, coronary revascularization or angina.

Preparation of azetidinone compounds and medical use thereof are provided by the present invention. More particularly, azetidionne compounds, shown as formula (I), wherein R¹, R², R³, R⁴, R⁵ and R⁶ are defined in description, and preparation methods thereof are provided by the present invention. The compounds of the present invention can reduce the levels of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) in plasma, and can be used as medicaments for reducing cholesterol in blood. Therefore the compounds of the present invention can be used to treat or prevent diseases of atherosclerosis, cacergasia of blood vessel, cardiac failure, coronary artery disease, angiocardiopathy, myocardial, angina, hyperlipoidemia and hypercholesteremia and the like. Preparation method of compounds of formula (I) and intermediate compounds are also provided by the present invention.

The invention relates to application of an oral hypoglycemic peptide. The application is used for preparing a medicine or a medicine composition for treating or preventing diabetes complicated with cardiovascular diseases. The oral hypoglycemic peptide is polypeptide OHP2. The polypeptide can effectively improve myocardial hypertrophy and fibrosis damage caused by the diabetes, reduce the contentof related myocardial enzymes, adjust the lipid metabolism level and improve myocardial cell oxidative stress and mitochondrial damage, so that the effect of protecting the heart is achieved; and therefore, the polypeptide can be used as a candidate molecule for treating or preventing the diabetes complicated with the cardiovascular diseases (especially diabetic cardiomyopathy), and has a good application prospect.

The invention relates to a medical examination diagnostic method and instrument, in particular to an electrocardio tomography imaging system and method. The electrocardio tomography imaging method is unique, is based on anatomical positioning, and is a non-invasive imaging technology used for detecting transmural electrocardio activity information (including a heart transmural electric potential, an electrocardiogram, an electrocardio activation map depolarization mode, and an electrocardio activation map repolarization mode). According to the electrocardio tomography imaging system and method, diagnosis of myocardium diseases such as myocardial hypertrophy, cardiomyopathy, myocardial infarction and myocarditis can be improved, sources of arrhythmia can be determined, and a novel diagnosis and treatment guidance tool is provided for quick real-time diagnosis of myocardial diseases.

The present invention relates to a human functional gene, especially CR-1 gene related to cell reconstitution, conduction and death. The gene is obtained through the comprehensive technological process of cDNA selection, EST location, genome DNA sequence analysis, PCR reaction and cloning end expanding, etc. Experiments including Northern and Western cross breeding detection of CR-1 gene expression in tumor cell, RNA interference immunohitochemistry detection of the expressino of CR-1 in myocardial tissue of myocardial disease patient, systemic research of the expression of CR-1 interacted protein and CR-1 gene in coliform bacteria and euaryotice cell, etc. show that the gene may be used as the target site in clinical diagnosis and treatment of myocardial disease and tumors.

The invention provides a traditional Chinese medicine for treating dilated cardiomyopathy and a preparation method thereof. The traditional Chinese medicine comprises stellaria media, liverwort, adiantum capillus-veneris, tiarella polyphylla, psammosilene tunicoides, centaury, woolly speedwell, phlomis umbrosa, rattan, euphorbia maculata, stauntonia latifolia, vervain, emblic leafflower fruits, herba aconiti, small-leaved desmodium roots, asteris souliei, anemone rivularis and indian pentanema herb. For treating dilated cardiomyopathy, the traditional Chinese medicine disclosed by the invention has the advantages of being low in side effect, good in curative effect, low in cost, high in cure rate, free from drug resistance, convenient to take and the like; and the traditional Chinese medicine disclosed by the invention has great advantages for improving symptoms and physical signs of patients suffering from dilated cardiomyopathy, adjusting the heart function class and increasing the survival rate of patients.

The invention provides a gene engineering method for improving age-related senescence of mesenchymal stem cells of aged rats. The method comprises the following steps: putting passage-stable mesenchymal stem cells obtained from marrow of the aged rats in a conventional culture medium provided with TPP1 overexpression slow virus particles (MOI is 100), infecting for 24 hours, and then replacing the culture medium into the conventional culture medium, adding puromycin in concentration of 5 microgrammes per microliter after 3 days, screening for 7 days, and applying the screened mesenchymal stem cells to cell transplantation therapy. The method has the beneficial effects that through overexpression of TPP1 in the mesenchymal stem cells of the aged rats, the age-related senescence of the mesenchymal stem cells of the aged rats can be obviously improved, so that the purpose of improving the effect of treating ischemic myocardial diseases can be achieved.

The invention discloses a hydrogel drug-loaded coating for treatment in an oxidative stress environment and a preparation method of the hydrogel drug-loaded coating. The preparation method comprises the following steps: S1, modifying hyaluronic acid with catechol; S2, crosslinking of the modified hyaluronic acid and cystamine; and S3, preparing the hydrogel drug-loaded coating. Hydrogel containing S-S bonds can be formed by modifying and cross-linking hyaluronic acid, and the hydrogel and allicin are sequentially sprayed on a substrate on which polydopamine is deposited, so that the hydrogel drug-loaded coating for the oxidative stress environment can be prepared. The coating can realize intelligent and accurate drug release aiming at heart diseases caused by various oxidative stress such as myocardial infarction, pyotoxic cardiomyopathy, atherosclerosis and the like in specific pathological environments, so that inhibition on the oxidative stress and regulation and control on subsequent inflammatory response of the oxidative stress are realized.