Traditional Chinese medicine preparation for treating pediatric viral myocarditis and preparation method thereof

A technology for viral myocarditis and traditional Chinese medicine preparations, applied in antiviral agents, anti-inflammatory agents, pharmaceutical formulations, etc., can solve problems such as inconvenience, achieve high yield, reduce the amount of auxiliary materials, and reduce clinical dosage effects.

Inactive Publication Date: 2013-01-02
张萍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide a Chinese medicine preparation for the treatment of viral myocarditis in children and a preparation method thereof. There are still many deficiencies in the medicines for the treatment of viral myocarditis in children at present. The treatment cycle is long, the side effects are large, the curative effect is not exact, and it is not easy to adh...

Method used

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  • Traditional Chinese medicine preparation for treating pediatric viral myocarditis and preparation method thereof
  • Traditional Chinese medicine preparation for treating pediatric viral myocarditis and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0052] The preparation method of the dropping pill of the present invention comprises the following steps: extracting 1500 g of Pinellia chinensis and 1500 g of Earthworm by ethanol distillation to obtain crystals, then 1500 g of Ophiopogon japonicus, 1500 g of salvia miltiorrhiza, 1500 g of cassia twig, 1500 g of scallion, 1500 g of red peony root, and 1500 g of schisandra , Radix Notoginseng 1500g, Astragalus 1500g, Trichosanthes 1500g, Forsythia 1500g, Baiziren 1500g, Atractylodes 1500g, Loofah 1500g, Angelica 1500g, Chuanxiong 1500g, Curcuma 1500g, Scutellaria baicalensis 1500g, Polygala 1500g, Woody 1500g, add 5-7 Double the amount of water, put it into a multi-functional extraction tank, keep the air pressure at 0.04-0.06mPa, decoct for 2 hours, and extract its water-soluble components; repeat the above steps for another 1.5 hours, and filter the extract through a 100-mesh sieve; Adsorb the resin to refine the filtrate, and elute with ethanol; the eluate is concentrated u...

experiment example 2

[0065] Experimental example 2: Acute toxicity and long-term toxicity test results

[0066] Acute toxicity test: give drop pill of the present invention by intragastric administration of mice, maximum concentration 35%, maximum intragastric capacity 0.4ml / 10g, dosage 14g / kg (every g of medicinal powder is equivalent to 10g crude drug), observe continuously 7 days, No toxic reaction was found, and the LD 50 of the drug could not be measured because the concentration and dose could not be increased. Determination of the maximum tolerated dose: with the highest concentration and the maximum gavage volume, the mice were gavaged three times with an interval of 5 hours, and then observed continuously for 7 days, and no case died. The dosage of the medicinal powder is >42g / kg.day (each g of medicinal powder is equivalent to 10g of crude drug), which is equivalent to 420 times of the clinical daily dosage of an adult in terms of kilogram body weight. Long-term toxicity test: In order ...

experiment example 3

[0067] Experimental example 3: Cumulative toxicity test:

[0068] Traditional Chinese medicine preparation of the present invention is taken orally honey refined pills to mice by 7.69, 19.18 and 43.21g crude drug / kg continuous medication 15 weeks (1.0ml / 100g body weight, every day 2 times) and after drug withdrawal 3 weeks, the result shows: Chinese medicine of the present invention The preparation has no obvious effect on the hair, behavior, defecation, body weight, organ weight, blood picture, liver and kidney function, blood sugar, blood lipid and other indicators of rats. After 1 week and 3 weeks after stopping the drug, there was no significant change in the organs of the rats. It shows that the oral capsule of the traditional Chinese medicine preparation of the present invention has little toxicity to rats after long-term administration, and there is no abnormal reaction after drug withdrawal, so the application is safe.

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Abstract

The invention provides a traditional Chinese medicine preparation for treating pediatric viral myocarditis. The preparation comprises raw materials of Radix Ophiopogon, therootofred-rootedsalvia, cassia twig, alliummacrostemon, rootofcommonpeony, Schisandra chinensis, pseudo-ginseng, Astragalusmongholicus, Fructus Trichosanthis, Fructus Forsythiae, Semen Platycladi, Rhizoma Atractylodis, luffa vegetable sponge, angelica, Ligusticumwallichii, curcuma zedoary, ginger processed pinellia, the root of large-flowered skullcap, polygala root, earthworm, and Radix aucklandiae. The invention aims to prepare a medicine for treating myocarditis from selected traditional Chinese medicines. The prepared medicine not only can improve the metabolism of myocardium and myocardial nutrition, protect the heart cells and improve myocardial disease resistance, but also can directly kill virus, reduce the damage of virus on myocardium, and realize combination of antivirus and overall regulation; and the medicine can reduce deputy effects caused by long-term application of Western medicine on the human body, and is an ideal medicine for treating myocarditis. In addition, the medicine prepared by the invention contains a large amount of active ingredients, employs cheap raw materials and simple preparation method, and can be widely used in clinical practice.

Description

technical field [0001] The invention relates to a medical preparation containing components derived from plants, animals or minerals, in particular to a traditional Chinese medicine preparation for treating children with viral myocarditis and a preparation method thereof. Background technique [0002] Myocarditis in children refers to myocardial confinement and chronic inflammation caused by various causes, although some myocarditis may develop into congestive or restrictive myocarditis in the terminal stage. In medical research, it can be found that the causes of myocarditis can be divided into: viruses, bacteria, fungi or parasites, and external conditions such as physical and chemical factors can cause myocarditis. Myocarditis refers to myocardial localized or diffuse acute or chronic inflammatory disease, which can be divided into two categories: infectious and non-infectious. Infectious myocarditis can be caused by viruses, bacteria, spirochetes, rickettsia, molds, pro...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K9/20A61K9/48A61K9/14A61K9/19A61P31/12A61P29/00
Inventor 梁轶聪李佃场魏志刚
Owner 张萍
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