31results about How to "Less excipients" patented technology

The invention relates to sugarless south isatis root granules and a preparation method thereof. The sugarless south isatis root granules are prepared from south isatis root, dyer woad leaf, amylin and steviosin and are prepared by decoction, concentration, standing, recovery, and drying in proportion. The method changes the original sugar granules into sugarless granules, uses the amylin to replace cane sugar, and adds a small amount of the steviosin to adjust the mouthfeel, reduces the saccharinity of the original sugar granules, and reduces the dosage of auxiliary materials and the cane sugar in the preparation. The applied dosage of the sugarless granules is not changed compared with that of the original sugar granules, so that the sugarless south isatis root granules can adapt to more patients.

The invention relates to the technical field of medicaments. The existing process for preparing particle preparations such as a lipid film comprises the step of dissolving a medicament into the oil for injection to form milky microspheres, so the prepared particle preparations have the defects of low medicament-loading amount, poor stability, large using amount of auxiliary materials and large toxic and side effect. The invention provides a method for preparing a freeze-drying particle preparation for injection, which comprises the following steps: firstly, dissolving water-insoluble medicinal powder into a volatile water-soluble organic solvent to form molecular medicinal solution, and then dispersing the molecular medicinal solution into the water for injection to form fluffy soft aggregate mixed suspension; and then adding a small amount of injection-grade auxiliary material such as dispersant and the like into the suspension, and obtaining the freeze-drying particle preparation for injection through a certain preparation process. The particle preparation prepared by the preparation method has the characteristics of small using amount of auxiliary materials, high medicament-loading amount, good stability, simple preparation process and the like. The preparation method of the invention has broad practicability, and basically can meet the preparation requirement of most water-insoluble powdery medicinal particle preparations.

The invention provides a wet treatment comprehensive recycling technology of copper anode mud. The wet treatment comprehensive recycling technology comprises the technological processes of carrying out high pressure leaching on the copper anode mud; copper leaching: carrying out copper electrowinning on a copper leaching solution; lead leaching: carrying out lead deposition on a lead leaching solution to obtain lead sulfate; gold leaching: carrying out reduction on a gold leaching solution to obtain coarse gold powder, and carrying out selenium tellurium platinum target procedure on the coarse gold powder to extract selenium, tellurium and platinum targets; silver leaching: carrying out reduction on a silver leaching solution to obtain coarse silver powder; casting a gold anode through the coarse gold powder, carrying out gold electrolysis, and carrying out electric gold casting to obtain gold ingots; and casting a silver anode through the coarse silver powder, carrying out silver electrolysis, and carrying out electric silver casting to obtain silver ingots. The wet treatment comprehensive recycling technology has the advantages that the working environment is improved, treatment quantity of downstream procedures is decreased, the recycling rate and direct recovery rate of elements are increased, and the loss rate of gold and silver is decreased.

The present invention provides a trospium chloride slow-release composition and a preparation method thereof. According to the trospium chloride slow-release composition, an active drug component trospium chloride, an enteric material and a slow-release material are directly mixed according to a specific ratio so as to be adopted as a slow-release coating layer, such that rapid-release, slow-release and enteric delayed-release can be integrated, the drug release behavior and the blood drug level are stable, the toxic-side effect is reduced, and the treatment effect is good. The trospium chloride slow-release composition comprises, by weight, 40-60 parts of a blank pill core, 20-30 parts of a drug loading layer wrapped on the blank pill core, 1-5 parts of a separation layer wrapped on the drug loading layer, and 20-30 parts of a slow-release coating layer wrapped outside the separation layer, wherein the active drug of the drug loading layer is trospium chloride, and the slow-release coating layer comprises, by weight, 19-26 parts of a slow-release material, 0.8-1.8 parts of an enteric material and 0.2-1.2 parts of trospium chloride.

The invention discloses a method for processing traditional Chinese medicinal ultramicro wall-broken capsule slices. The method mainly comprises the steps of standardizing, processing and cutting single traditional Chinese medicinal material, then removing pesticide residues through high-pressure cleaning, drying, processing the cut traditional Chinese medicinal materials into coarse powder, dipping to remove heavy metal, processing the coarse powder into ultramicro wall-broken powder through ultramicro grinding, mixing the ultramicro wall-broken powder with pharmaceutical adjuvant powder according to a certain ratio and sterilizing after reaching the standard of quality control to finally obtain the capsule slices. The new capsule slices are prepared from single traditional Chinese medicinal slice, can be directly swallowed without brewing, and integrate the advantages of ultramicro power and capsule, so that the effective time can be controlled, the usage amount of the pharmaceutical adjuvants is less, the drug-loading rate is high, and a new method is innovated for the modernization of traditional Chinese medicines.

The invention discloses a calcium dobesilate capsule, which is prepared from the following components in parts by weight: 521.5 parts of calcium dobesilate, 25-50 parts of starch and 5-10 parts of a lubricant, wherein the calcium dobesilate is calcium dobesilate monohydrate. The invention also discloses a preparation method of the calcium dobesilate capsule. The method comprises the following steps: weighing the calcium dobesilate and the starch at the formula ratio, and carrying out dry granulating; and adding the lubricant at the formula ratio, mixing evenly, filling, polishing, and blistering, so as to obtain the calcium dobesilate capsule. The calcium dobesilate capsule disclosed by the invention is low in dosage of raw and auxiliary materials and stable in quality; meanwhile, relatively good stability is obtained by adopting the preparation method disclosed by the invention and combing with dry granulating; the character and the stability of the calcium dobesilate capsule during the storage period are significantly improved; the overall process is simple; a lot of manpower and material resources can be saved; and the calcium dobesilate capsule can be applied to industrialized production.

The invention discloses a preparation method of ginger-processed pinellia tubers. The preparation method of the ginger-processed pinellia tubers includes the steps of cleaning, wherein impurities in the pinellia tubers are picked out on a worktable to obtain clean pinellia tubers; grading, wherein the clean pinellia tubers in step 1 are screened and graded for use; washing, wherein the cleaned andgraded pinellia tubers are put into a medicinal material washing machine for washing; soaking, wherein the screened and graded pinellia tubers are put into a medicinal material soaking tank for soaking with water; decocting, wherein ginger slices are put into a decocting pot, a right amount of water is added for decocting, then alumen and the soaked pinellia tubes are added for boiling until no white hearts exit, the pinellia tubes are taken out, the ginger slices are removed, and the pinellia tubes are aired by sixty percent; cutting, wherein the boiled pinellia tubes are cut into flakes through a medicinal material cutting machine; drying, wherein the boiled pinellia tubes or cut pinellia tube flakes are dried, and after natural cooling, sieving is carried out to remove medicinal chips;packaging, detection and warehousing. The ginger-processed pinellia tubers obtained by the method are stable in quality, the process is simple, the operation is convenient, and the ginger-processed pinellia tubers are suitable for large-scale industrial production.

The invention belongs to the field of medicine preparation and relates to a gabapentin tablet which is prepared by wet granulation and prepared mainly from the following raw materials by weight percentage: 80.0% or more of gabapentin, 4.0-17.0% of low-substituted hydroxypropyl cellulose, 0.5-2.5% of adhesive, 0.1-2.5% of stabilizer and 0.5-1.5% of lubricant. The invention further provides a preparation method of the gabapentin tablet. The gabapentin raw material adopted in the invention has good formability and high physical strength after being crushed. Besides, the gabapentin raw material can be prepared by adopting an ordinary wet granulation method and has the characteristics of simple preparation and low cost. The gabapentin tablet provided by the invention has the advantages of very high dissolution in vitro, high content of gabapentin, less application auxiliary materials and high convenience for use, thus meeting modern medicine's requirements of 'small in three aspects' and 'convenient in three aspects', and can be prepared by adopting an ordinary wet granulation method and has the characteristics of simple preparation and low cost.

The invention provides an American ginseng extract pellet preparation, which is prepared from an American ginseng extract and pharmaceutical adjuvants and is characterized in that the pharmaceutical adjuvants comprise an excipient and an adhesive; and in the pellet preparation, the weight percentage of the American ginseng extract is 1-75%, the weight percentage of the excipient is 17-98% and the percentage of the adhesive is 1-8%. The pellet preparation can be prepared into a sustained-release or intestine-soluble preparation as required. Pharmacological experiments show that the pellet provided by the invention has the actions of resisting fatigue, resisting aging, enhancing human immunity, improving cardiovascular functions and the like.

The invention discloses a cynomorium songaricum spirulina preparation with synergistic effect, in particular to a table with low accessories content. The preparation has certain curative effect for treating sexual dysfunction and prostatitis. According to the invention, the cynomorium songaricum extracts match with the spirulina scientifically, so that the raw material selection is novel, scientific and reasonable; the preparation method is simple; and the product quality is steady.

A Chinese medicine in the form of tablet for nourishing qi and Yin, promoting blood circulation and pulse, heart blood stagnation, cardialgia, palpitation, etc is prepared from 6 Chinese-medicinal materials including ginseng, astragalus root, red sage root, Chuan-xiong rhizome, etc, lubricant and diluent (microcrystalline cellulose) through extracting in water, removing solvent to obtain powder and other conventional steps.

The invention relates to clarified propofol injection and a preparation method thereof. The injection includes propofol, cyclodextrin, a stabilizing agent, a pH regulating agent and injection water; the pH value of the injection is 6-9, and preferably is 7-8.5. The injection can be filtered online, and is few in ingredient kinds, low in using amount, low in free propofol concentration, convenientin storage and good in stability.

The invention discloses a betulinic acid nanometer suspension and a preparation method thereof. The betulinic acid nanometer suspension is mainly prepared from betulinic acid and a stabilizing agent,wherein the stabilizing agent comprises poloxamer 188 and egg yolk lecithin. Compared with betulinic acid self-assembled nanoparticles or betulinic acid nanoemulsion and the like in the prior art, theobtained betulinic acid nanometer suspension is lower in consumption of auxiliary materials, the saturation solubility and the dissolving out rate of medicines are notably increased, restraining of accumulation of particles is facilitated, and the betulinic acid nanometer suspension has long-term physical stability. Organic solvents are not added, and an environment-friendly idea is merged, so that a nanometer preparation being green, non-toxic and high in medicine carrying amount is creatively obtained. In vivo pharmacokinetics research shows that Cmax and AUC<0-t> are notably increased, andthe trend that the smaller the particle diameters are, the larger the AUC is, and the higher the biological availability is presented. The AUC of the betulinic acid nanometer suspension of which theparticle diameter is about 160nm is the highest, the biological availability is notably improved, and the betulinic acid nanometer suspension is favorable for natural products having various bioactivity to be used as a medicine for clinical application further.

The invention discloses a solid oral preparation containing montelukast and a preparation method of the solid oral preparation. The preparation comprises the following steps: crushing and screening montelukast; mixing the crushed and screened montelukast with dried pregelatinized starch and sucrose fatty acid ester evenly; and tabletting. Compared with the prior art, the solid oral preparation has the advantages of low auxiliary material amount and simple preparation technology; and meanwhile, the stability of the montelukast tablet is relatively well improved.

The invention discloses a preparing method of a preparation for treating joint pain and waist and leg pain. The preparing method includes: placing the extraction clear paste of radix aconiti preparata, radix aconiti kusnezoffii preparata, radix stephaniae tetrandrae, radix sileris, radix dipsaci, radix achyranthis bidentatae, ramulus cinnamomi, radix clematidis and herba geranii at the top of a chromatographic column filled with D101 macroporous resin, performing ethanol elution, collecting the eluent, and concentrating into extract; adding the extract into a sodium alginate solution, and stirring into aqueous phase; heating and evenly mixing liquid paraffin and polysorbate to obtain oil phase; slowly adding the aqueous phase into the oil phase, fast cooling, adding isopropanol, standing,filtering, separating, and subjecting the solid to vacuum drying to obtain microcapsules; adding auxiliaries into the microcapsules, evenly mixing, tableting, and coating to obtain the preparation. The preparing method has the advantages that the stability and effectiveness of the preparation can be increased evidently, stable and gentle medicine release can be achieved, the toxic and side effectsof medicine are lowered evidently, and medicine bioavailability is increased; the preparing method is simple in process, easy to operate, low in production cost, easy to achieve industrial productionand promising in popularization prospect.

The invention provides a cobamamide freeze-drying preparation composition for injection and a preparing method thereof. The cobamamide freeze-drying preparation composition for injection is prepared from cobamamide, mannitol, isoamyl acetate, sodium pyrosulfite and the like. The cobamamide freeze-drying preparation composition for injection has the advantages of being high in stability, low in related substance content, suitable for industrial production and the like.