A kind of solid oral preparation containing montelukast sodium and preparation method thereof
A technology of montelukast sodium and oral preparations, which is applied in the field of solid oral preparations containing montelukast sodium and its preparation, and can solve the problem of poor wet stability, sensitivity, and inability to fundamentally solve the stability of montelukast sodium problems and other problems, to achieve the effects of improved stability, less auxiliary material consumption, and simple preparation process
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Embodiment 1
[0028] Montelukast Sodium 10g
[0029] 100g pregelatinized starch
[0030] Sucrose Fatty Acid Ester 4g
[0031] Preparation Process:
[0032] Grind montelukast sodium through an 80-mesh sieve, and set aside; dry the pregelatinized starch at 105°C, airtightly let it cool, and set aside; weigh the amount of montelukast sodium, pregelatinized starch, and sucrose fatty acid ester and mix evenly , Φ6.5mm shallow arc stamping sheet, that is. After testing, the initial moisture content of the tablet was 0.91%.
Embodiment 2
[0034] Montelukast Sodium 10g
[0035] 200g pregelatinized starch
[0036] Sucrose Fatty Acid Ester 11g
[0037] Preparation Process:
[0038]Grind montelukast sodium through an 80-mesh sieve, and set aside; dry the pregelatinized starch at 105°C, airtightly let it cool, and set aside; weigh the amount of montelukast sodium, pregelatinized starch, and sucrose fatty acid ester and mix evenly , Φ9mm shallow arc stamping sheet, that is. After testing, the initial moisture content of the tablet was 0.42%.
Embodiment 3
[0040] Montelukast Sodium 10g
[0041] 300g pregelatinized starch
[0042] Sucrose Fatty Acid Ester 20g
[0043] Preparation Process:
[0044] Grind montelukast sodium through an 80-mesh sieve, and set aside; dry the pregelatinized starch at 105°C, airtightly let it cool, and set aside; weigh the amount of montelukast sodium, pregelatinized starch, and sucrose fatty acid ester and mix evenly , Φ10mm shallow arc stamping sheet, that is. After testing, the initial moisture content of the tablet was 0.59%.
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