Calcium dobesilate capsule

A technology of calcium dobesilate and capsules, applied in the directions of capsule delivery, anhydride/acid/halide active ingredients, metabolic diseases, etc., can solve problems such as poor uniformity, oxidative deterioration of calcium dobesilate capsules, etc. The effect of reducing the amount of excipients, ensuring consistency and biological efficacy, improving properties and stability

Inactive Publication Date: 2015-03-25
CHENGDU YILUKANG MEDICAL TECH & SERVICE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The purpose of the present invention is to overcome the deficiencies in the prior art that calcium dobesilate capsules are prone t

Method used

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  • Calcium dobesilate capsule
  • Calcium dobesilate capsule
  • Calcium dobesilate capsule

Examples

Experimental program
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Effect test

Embodiment 1

[0032] Conventional method: powder direct filling meter, 1000 capsules

[0033] Get calcium dobesilate 521.5g, starch 25g, magnesium stearate 5g, pulverize and pass through a 60-mesh sieve. First, mix calcium dobesilate and starch (the amount weighed is added without specifying the quantity, the same below), then add magnesium stearate and mix well, and then fill the capsules with an automatic capsule filling machine to obtain hydroxybenzenesulfonate Calcium sulfonate capsules.

Embodiment 2

[0035] The invention provides a method, dry granulation, calculated in 1000 grains

[0036] Get calcium dobesilate 521.5g, starch 25g, magnesium stearate 5g, pulverize and pass through a 60-mesh sieve. First mix calcium dobesilate and starch, dry granulate; then add magnesium stearate and mix evenly, fill capsules with an automatic capsule filling machine to obtain calcium dobesilate capsules.

Embodiment 3

[0038] The invention provides a method, dry granulation, calculated in 1000 grains

[0039] Get calcium dobesilate 521.5g, starch 25g, sodium carboxymethyl starch 25g, magnesium stearate 5g, pulverize and pass through a 40-mesh sieve. First mix calcium dobesilate, starch and 15g sodium carboxymethyl starch, and dry granulate; then add magnesium stearate and the remainder of 10g sodium carboxymethyl starch, mix well, and fill the capsules with an automatic capsule filling machine , to obtain calcium dobesilate capsules.

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Abstract

The invention discloses a calcium dobesilate capsule, which is prepared from the following components in parts by weight: 521.5 parts of calcium dobesilate, 25-50 parts of starch and 5-10 parts of a lubricant, wherein the calcium dobesilate is calcium dobesilate monohydrate. The invention also discloses a preparation method of the calcium dobesilate capsule. The method comprises the following steps: weighing the calcium dobesilate and the starch at the formula ratio, and carrying out dry granulating; and adding the lubricant at the formula ratio, mixing evenly, filling, polishing, and blistering, so as to obtain the calcium dobesilate capsule. The calcium dobesilate capsule disclosed by the invention is low in dosage of raw and auxiliary materials and stable in quality; meanwhile, relatively good stability is obtained by adopting the preparation method disclosed by the invention and combing with dry granulating; the character and the stability of the calcium dobesilate capsule during the storage period are significantly improved; the overall process is simple; a lot of manpower and material resources can be saved; and the calcium dobesilate capsule can be applied to industrialized production.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a calcium dobesilate capsule and a preparation method thereof. Background technique [0002] Calcium dobesilate capsules, English name: Calcium Dobesilate Capsules. The main ingredient of this product is calcium dobesilate, its chemical name is: 2,5-dihydroxybenzenesulfonate calcium monohydrate, and its structural formula is as follows: [0003] [0004] Calcium dobesilate capsules mainly regulate the function of microcirculation by regulating the physiological function of microvascular wall, reducing plasma viscosity, reducing platelet aggregation and other mechanisms, so as to treat retinal microcirculation lesions caused by diabetes. [0005] Calcium dobesilate capsule is an oral vascular protective agent, which can significantly inhibit and reverse the "three high" factors of diabetic retinopathy (DR). It can reduce capillary hyperpermeabi...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/185A61K47/38A61K47/36A61K47/26A61P3/10A61P9/10
Inventor 唐泉
Owner CHENGDU YILUKANG MEDICAL TECH & SERVICE
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