Preparing method of preparation for treating joint pain and waist and leg pain

Abstract

The invention discloses a preparing method of a preparation for treating joint pain and waist and leg pain. The preparing method includes: placing the extraction clear paste of radix aconiti preparata, radix aconiti kusnezoffii preparata, radix stephaniae tetrandrae, radix sileris, radix dipsaci, radix achyranthis bidentatae, ramulus cinnamomi, radix clematidis and herba geranii at the top of a chromatographic column filled with D101 macroporous resin, performing ethanol elution, collecting the eluent, and concentrating into extract; adding the extract into a sodium alginate solution, and stirring into aqueous phase; heating and evenly mixing liquid paraffin and polysorbate to obtain oil phase; slowly adding the aqueous phase into the oil phase, fast cooling, adding isopropanol, standing,filtering, separating, and subjecting the solid to vacuum drying to obtain microcapsules; adding auxiliaries into the microcapsules, evenly mixing, tableting, and coating to obtain the preparation. The preparing method has the advantages that the stability and effectiveness of the preparation can be increased evidently, stable and gentle medicine release can be achieved, the toxic and side effectsof medicine are lowered evidently, and medicine bioavailability is increased; the preparing method is simple in process, easy to operate, low in production cost, easy to achieve industrial productionand promising in popularization prospect.

Description

technical field [0001] The invention relates to a preparation method of a preparation for treating joint pain and waist and leg pain. Background technique [0002] Rheumatic bone pain is caused by wind-cold-damp evil invading the human body. After wind-cold-damp evil invades the human body, it will block the tendons and arteries. Joint pain, morning stiffness (the patient's joints are sticky and stiff after waking up or resting for a long time, and can be relieved or disappeared after activities), joint swelling and tenderness (appearing in painful joints, which is synovitis or surrounding Symptoms of soft tissue inflammation, the degree of which varies with the degree of inflammation) and joint swelling and pain (knuckles lose their normal shape and range of motion is limited, such as knees cannot be fully straightened, ulnar deviation of the metacarpophalangeal joints of the hands, Joint subluxation, etc.), among the above symptoms, morning stiffness is the most prominent...

AI Technical Summary

Problems solved by technology

However, this product is a plain tablet without coating protection, and its excipients such as mannitol have strong hygroscopicity, and it is easy to absorb moisture during storage, resulting in mottled spots on the surface of the tablet and other phenomena that affect the quality of the finished product, and may even cause some adverse reactions happened

[0008] The currently commercially available Fengshiling Tablets were produced in the early 1990s, but due to limited conditions at that time and underground preparation techniques, they were simply decocted in water and concentrated to make tablets, and most of the impurities could not be removed. The tablets made are not only taken in a large amount (10 tablets each time, twice a day), but also have problems such as long melting time and low bioavailability after taking, which greatly affect the effectiveness and stability of the drug. also directly affect the efficacy of the treatment

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