Preparing method of preparation for treating joint pain and waist and leg pain

A technology for low back and leg pain and joint pain, which is applied to the preparation of low back and leg pain preparations and the field of treating joint pain, can solve the problems of affecting the effectiveness and stability of drugs, affecting the effect of treatment, low bioavailability, etc. The effect of utilization, reducing the amount of excipients, and reducing the burden on the body

Pending Publication Date: 2020-02-28
广西大海阳光药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this product is a plain tablet without coating protection, and its excipients such as mannitol have strong hygroscopicity, and it is easy to absorb moisture during storage, resulting in mottled spots on the surface of the tablet and other phenomena that affect the quality of the finished product, and may even cause some adverse reactions happened
[0008] The currently commercially available Fengshiling Tablets were produced in the early 1990s, but due to limited c

Method used

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  • Preparing method of preparation for treating joint pain and waist and leg pain
  • Preparing method of preparation for treating joint pain and waist and leg pain

Examples

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Example Embodiment

[0045] Example 1

[0046] A preparation method of an active ingredient of a preparation for treating joint pain and lumbago and leg pain, comprising the following steps:

[0047] (1) Take 100 parts of C. chinensis, 100 parts of Caowu, 100 parts of Fangji, 100 parts of Fangfeng, 100 parts of continuation, 100 parts of Achyranthes, 100 parts of Guizhi, 100 parts of Wei Lingxian and 100 parts of geranium, decocted twice with water, the amount of water added each time was 8 times the total weight of the medicinal materials, the extraction time was 3 hours and 2 hours each time, the decoction was combined, filtered, and the filtrate was concentrated under reduced pressure to a temperature of 65°C. Clear paste with a relative density of 1.10;

[0048] (2) Take the clear paste and put it into the top of the column filled with D101 macroporous resin. The mass of the clear paste is 5 times that of the D101 macroporous resin. Elute with 65% ethanol by volume, and collect the volume of ...

Example Embodiment

[0051] Example 2

[0052] A preparation method of an active ingredient of a preparation for treating joint pain and lumbago and leg pain, comprising the following steps:

[0053] (1) Take 100 parts of C. chinensis, 100 parts of Caowu, 100 parts of Fangji, 100 parts of Fangfeng, 100 parts of continuation, 100 parts of Achyranthes, 100 parts of Guizhi, 100 parts of Wei Lingxian and 100 parts of geranium, add water to decoct 3 times, the amount of water added each time is 8 times, 7 times, and 6 times the total weight of the medicinal materials, and the extraction time is 3 hours, 2 hours, and 2 hours each time. Combine the decoctions, filter , the filtrate was concentrated under reduced pressure into a clear paste with a relative density of 1.12 at 65°C;

[0054] (2) Take the clear paste and put it into the top of the column filled with D101 macroporous resin. The mass of the clear paste is 5 times that of the D101 macroporous resin. Elute with 60% ethanol by volume and collect...

Example Embodiment

[0057] Example 3

[0058] A preparation method of an active ingredient of a preparation for treating joint pain and lumbago and leg pain, comprising the following steps:

[0059] (1) Take 100 parts of C. chinensis, 100 parts of Caowu, 100 parts of Fangji, 100 parts of Fangfeng, 100 parts of continuation, 100 parts of Achyranthes, 100 parts of Guizhi, 100 parts of Wei Lingxian and 100 parts of geranium, add water to decoct twice, the amount of water added each time is 7 times the total weight of the medicinal material, the extraction time is 3 hours and 2 hours each time, the decoction is combined, filtered, and the filtrate is concentrated under reduced pressure to a temperature of 65°C. Clear paste with a relative density of 1.20;

[0060] (2) Take the clear paste and put it into the top of the column filled with D101 macroporous resin. The mass of the clear paste is 5 times that of the D101 macroporous resin. Elution is carried out with 55% ethanol, and the volume of the cl...

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Abstract

The invention discloses a preparing method of a preparation for treating joint pain and waist and leg pain. The preparing method includes: placing the extraction clear paste of radix aconiti preparata, radix aconiti kusnezoffii preparata, radix stephaniae tetrandrae, radix sileris, radix dipsaci, radix achyranthis bidentatae, ramulus cinnamomi, radix clematidis and herba geranii at the top of a chromatographic column filled with D101 macroporous resin, performing ethanol elution, collecting the eluent, and concentrating into extract; adding the extract into a sodium alginate solution, and stirring into aqueous phase; heating and evenly mixing liquid paraffin and polysorbate to obtain oil phase; slowly adding the aqueous phase into the oil phase, fast cooling, adding isopropanol, standing,filtering, separating, and subjecting the solid to vacuum drying to obtain microcapsules; adding auxiliaries into the microcapsules, evenly mixing, tableting, and coating to obtain the preparation. The preparing method has the advantages that the stability and effectiveness of the preparation can be increased evidently, stable and gentle medicine release can be achieved, the toxic and side effectsof medicine are lowered evidently, and medicine bioavailability is increased; the preparing method is simple in process, easy to operate, low in production cost, easy to achieve industrial productionand promising in popularization prospect.

Description

technical field [0001] The invention relates to a preparation method of a preparation for treating joint pain and waist and leg pain. Background technique [0002] Rheumatic bone pain is caused by wind-cold-damp evil invading the human body. After wind-cold-damp evil invades the human body, it will block the tendons and arteries. Joint pain, morning stiffness (the patient's joints are sticky and stiff after waking up or resting for a long time, and can be relieved or disappeared after activities), joint swelling and tenderness (appearing in painful joints, which is synovitis or surrounding Symptoms of soft tissue inflammation, the degree of which varies with the degree of inflammation) and joint swelling and pain (knuckles lose their normal shape and range of motion is limited, such as knees cannot be fully straightened, ulnar deviation of the metacarpophalangeal joints of the hands, Joint subluxation, etc.), among the above symptoms, morning stiffness is the most prominent...

Claims

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Application Information

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IPC IPC(8): A61K36/716A61K9/28A61P29/00A61P19/02
CPCA61K36/714A61K36/59A61K36/238A61K36/185A61K36/21A61K36/54A61K36/716A61K9/28A61K9/2054A61K9/2027A61P29/00A61P19/02A61K2236/331A61K2236/39A61K2236/55
Inventor 黄大权唐新邓春霞
Owner 广西大海阳光药业有限公司
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