Betulinic acid nanometer suspension and preparation method thereof
A nano-suspension, betulinic acid technology, applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of reducing drug safety, low encapsulation rate, and increased heart rate. Nephrotoxicity and neurotoxicity and other problems, to achieve the effect of increasing saturation solubility and dissolution rate, solubility and dissolution rate improvement, and green non-toxic drug loading
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[0037] Example 1
[0038] Weigh 2mg of Poloxamer 188 (P188) or 2mg of egg yolk lecithin into 20ml of deionized water and stir it magnetically at 600rpm for 30min to fully saturate the stabilizer in the water; weigh 40mg of betulinic acid and add it to the aqueous stabilizer solution, magnetically at 600rpm Stir for 30 minutes; place the above liquid in an ultrasonic cell disruptor for 5 minutes to obtain a crude suspension; subject the above crude suspension to media milling at 1500 rpm for 95 minutes to obtain a betulinic acid nano-suspension. The measured particle size is 946±105.9nm, and the polydispersity coefficient (PDI) is 0.51±0.13.
Example Embodiment
[0039] Example 2
[0040] Weigh 4mg of poloxamer 188 (P188) or 4mg of egg yolk lecithin into 20ml of deionized water and stir it magnetically at 600rpm for 30min to fully saturate the stabilizer in the water; weigh 40mg of betulinic acid and add it to the stabilizer aqueous solution, magnetically at 600rpm Stir for 30 minutes; place the above liquid in an ultrasonic cell disruptor for 5 minutes to obtain a crude suspension; subject the above crude suspension to media milling at 1500 rpm for 95 minutes to obtain a betulinic acid nano-suspension. The measured particle size is 918±39.7nm, and the polydispersity coefficient (PDI) is 0.31±0.17.
Example Embodiment
[0041] Example 3
[0042] Weigh 3mg of poloxamer 188 (P188) and 3mg of egg yolk lecithin into 20ml of deionized water and stir it magnetically at 600rpm for 30min to fully saturate the stabilizer in the water; weigh 40mg of betulinic acid and add it to the stabilizer aqueous solution, magnetically at 600rpm Stir for 30 minutes; place the above liquid in an ultrasonic cell disruptor for 5 minutes to obtain a crude suspension; subject the above crude suspension to media milling at 1500 rpm for 95 minutes to obtain a betulinic acid nano-suspension. The measured particle size is 909±22.8nm, and the polydispersity coefficient (PDI) is 0.27±0.05.
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