Gas explosion lung injury diagnosis system, serum marker screening method and lung injury action mechanism research method

A serum marker and gas explosion technology, applied in the field of gas explosion lung injury diagnosis system, achieves high sensitivity and good specificity

Inactive Publication Date: 2020-11-27
XINXIANG MEDICAL UNIV
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Problems solved by technology

However, so far there has been no report on the use of metabolomics methods to study the mechanism of gas explosion lung injury at home and abroad. Therefore, it is necessary to develop a research method based on metabolomics modeling technology to identify the mechanism of gas explosion lung injury.

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  • Gas explosion lung injury diagnosis system, serum marker screening method and lung injury action mechanism research method
  • Gas explosion lung injury diagnosis system, serum marker screening method and lung injury action mechanism research method
  • Gas explosion lung injury diagnosis system, serum marker screening method and lung injury action mechanism research method

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Embodiment Construction

[0054] Below, the present invention will be further explained through the following specific embodiments, and the advantages of the present invention will be further proved, but not limited thereto.

[0055] 1. Research object

[0056] In this study, the serum and lung tissue samples of rats exposed to gas explosions in a real roadway environment were used as gas explosion lung injury samples; non-invasive and non-injured rats were selected as control samples by random grouping.

[0057] In this study, a total of 24 cases were detected, including 16 positive rats that participated in the gas explosion with the characteristics of gas explosion lung injury, and 8 non-invasive negative control rats that did not participate in the explosion; there was no statistically significant difference in body weight between the two groups, and comparability.

[0058] 2. Morphological and pathological effects of gas explosion on body weight, respiratory function and lung tissue of rats with ...

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Abstract

The invention relates to the technical field of medical diagnosis mathematical modeling, and particularly relates to a gas explosion lung injury diagnosis system, a serum marker screening method and alung injury action mechanism research method. According to the invention, a serum metabonomics analysis model is constructed based on LC-MS to obtain a PLS-DA model; and nine specific biomarkers withthe effect of causing gas explosion lung injury are obtained by screening through a metabonomics research method, so that the diagnosis and treatment efficiency of coal mine full-gas explosion injurycrowds is effectively improved, important clinical value and social significance are achieved, and the popularization and application are facilitated. The identification and high-throughput analysisof the action mechanism of the gas explosion lung injury are achieved through a standard substance of BioNovoGene company and the HMDB, massbank, Metlin and KEGG databases, the gas explosion lung injury action mechanism is comprehensively analyzed and evaluated on the overall level, and guidance and predictive research are provided for clarification of metabonomics and the action mechanism of thecoal mine gas explosion lung injury.

Description

technical field [0001] The invention relates to the technical field of medical diagnosis mathematical modeling, in particular to a gas explosion lung injury diagnosis system, a serum marker screening method, and a lung injury mechanism research method. Background technique [0002] The main gas components of gas are alkanes, of which methane accounts for the vast majority, and a small amount of ethane, propane and butane, in addition to hydrogen sulfide, carbon dioxide, nitrogen and water vapor, and traces of inert gases. A gas explosion can occur when the gas concentration is 5%-15%, the oxygen concentration in the air is not lower than 12%, and there is an open flame. my country is a big coal country, and its coal output accounts for about 50% of the world's total output. The proportion of coal consumption in my country in recent decades has been around 70%. It is estimated that by 2030, the proportion of coal consumption as primary energy will remain at around 50% of tot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/72G01N30/86G16H50/50
CPCG01N30/02G01N30/72G01N30/8686G01N30/8693G01N30/8696G16H50/50
Inventor 任文杰董新文姚三巧吴卫东王天云曹佳姚武李海斌李娟田林强
Owner XINXIANG MEDICAL UNIV
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