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Buccal tablet applicable to being taken for type II diabetes

A technology for buccal tablets and diabetes, which is applied in the field of buccal tablets, can solve problems such as drug application restrictions and side effects, and achieve the effects of overcoming drug application restrictions, lowering blood sugar, and avoiding loss

Inactive Publication Date: 2014-11-05
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The current treatment options for type II diabetes are mainly oral hypoglycemic drugs and long-term use of insulin, but they all have different degrees of side effects, and the application of drugs is limited, which cannot meet the needs of today’s fast-paced life and the ever-improving taste of life, so I chose Buccal tablet dosage forms with long-lasting hypoglycemic effect, low toxicity, convenient administration, easy storage and portability become necessary
[0003] After searching, there is no report on buccal tablets made of Icelandic sea cucumber, sea cucumber, fucoidan sulfate, astragalus polysaccharide, raw land extract, tremella polysaccharide, etc. for type II diabetes

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] In parts by weight, the unit is kilogram, and weighed respectively: 21 parts of Icelandic japonicus sea cucumber fucoidan sulfate, 18 parts of astragalus polysaccharide, 15 parts of raw land extract, 16 parts of tremella polysaccharide, 9 parts of microcrystalline cellulose, wood 8 parts of sugar alcohol, 8 parts of magnesium stearate, 4.6 parts of sodium citrate, 0.4 part of mint essence;

[0035] Wherein: the above-mentioned Icelandic japonicus sea cucumber fucoidan sulfate is prepared by the following method:

[0036] Crush the dry Icelandic japonicus japonicus, soak in acetone for 24 hours to degrease, and dry at room temperature; according to 1 g of dry matter, add 30 mL of papain enzymatic hydrolyzate to the degreased dry matter, stir and react in a water bath at 60°C for 24 h, 4000r / Centrifuge for 15 min; add 1.6mL of 10% cetylpyridinium chloride solution to the supernatant, discard the supernatant, dissolve the precipitate in 15mL of 3mol / L NaCl-15% ethanol sol...

Embodiment 2

[0051] In parts by weight, the unit is kilogram, and weighed respectively: 22 parts of Icelandic japonicus japonicus and sea cucumber fucoidan sulfate, 19 parts of astragalus polysaccharide, 16 parts of raw land extract, 16 parts of white fungus polysaccharide, 11 parts of microcrystalline cellulose, wood 9 parts of sugar alcohol, 9 parts of magnesium stearate, 4.5 parts of sodium citrate, 0.5 part of mint essence;

[0052] Wherein: the above-mentioned Icelandic japonicus sea cucumber fucoidan sulfate is prepared by the following method:

[0053] Crush the dry Icelandic japonicus japonicus, soak in acetone for 24 hours to degrease, and dry at room temperature; according to 1 g of dry matter, add 30 mL of papain enzymatic hydrolyzate to the degreased dry matter, stir and react in a water bath at 60°C for 24 h, 4000r / Centrifuge for 15 min; add 1.6mL of 10% cetylpyridinium chloride solution to the supernatant, discard the supernatant, dissolve the precipitate in 15mL of 3mol / L N...

Embodiment 3

[0067] In parts by weight, the unit is kilogram, and weighed respectively: 18 parts of Icelandic japonicus sea cucumber fucoidan sulfate, 17 parts of astragalus polysaccharide, 14 parts of raw land extract, 15 parts of tremella polysaccharide, 9 parts of microcrystalline cellulose, wood 7.7 parts of sugar alcohol, 7 parts of magnesium stearate, 4 parts of sodium citrate, 0.3 part of mint essence.

[0068] Wherein: the sources of above-mentioned iceland sea cucumber sea cucumber fucoidan sulfate, astragalus polysaccharide, habitat extract, and tremella polysaccharide are the same as those in Example 1.

[0069] Mix the above-mentioned Icelandic sea cucumber sea cucumber fucoidan sulfate, astragalus polysaccharide, raw ground extract, tremella polysaccharide, and microcrystalline cellulose thoroughly, then fully mix with xylitol and sodium citrate, and evenly moisten with water. The mixture is sieved and dried, then sieved, granulated, magnesium stearate and peppermint essence a...

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Abstract

The invention discloses a buccal tablet applicable to being taken for type II diabetes. The buccal tablet is prepared from the following components in parts by weight: 18-22 parts of island stichopus japonicas sea cucumber fucoidan chitosan sulfate, 17-19 parts of astragalus polysaccharide, 14-16 parts of rehmannia extract, 15-16 parts of tremella polysaccharide, 9-12 parts of microcrystalline cellulose, 7-9 parts of newtol, 7-9 parts of magnesium stearate, 4-5 parts of sodium citrate, and 0.3-0.5 part of peppermint essence. By adopting the buccal tablet disclosed by the invention, the fasting blood-glucose content of the mice with the type II diabetes can be obviously reduced; the tolerance dose of oral glucose is improved; C peptide and fasting insulin level in the blood are increased. Therefore, the buccal tablet has the advantages of being convenient to take, easy to store, high in bioavailability, convenient to carry, and suitable for living demands of fast-paced people.

Description

technical field [0001] The invention relates to a buccal tablet, in particular to a buccal tablet suitable for type II diabetes. Background technique [0002] The current treatment options for type II diabetes are mainly oral hypoglycemic drugs and long-term use of insulin, but they all have different degrees of side effects, and the application of drugs is limited, which cannot meet the needs of today's fast-paced life and the ever-improving taste of life, so I chose The buccal tablet dosage form with long-lasting hypoglycemic effect, low toxicity, convenient administration, easy storage and portability becomes necessary. [0003] After searching, there is no report on the buccal tablet dosage form made of Icelandic sea cucumber sea cucumber fucoidan sulfate, astragalus polysaccharide, rehmannia extract, tremella polysaccharide, etc. for type II diabetes. Contents of the invention [0004] Aiming at the deficiencies of the prior art, the problem to be solved by the prese...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/804A61K9/20A61P3/10A61K31/715
Inventor 张尚立张恒马剑峰
Owner SHANDONG UNIV
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