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Traditional Chinese medicine composition and application thereof in preparation of drug for treating IR

A kind of composition and medicine technology, applied in the field of application in the preparation of IR medicines

Inactive Publication Date: 2021-02-02
SHANGHAI TONGREN HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment for patients with post-stroke muscle spasm is mostly focused on the recovery of limb function and the improvement of quality of life, while the IR that is common in patients with stroke muscle spasm and the intervention of cardiovascular and cerebrovascular malignant events caused by it (Lin Liming, The impact of ideal cardiovascular behaviors and factors on cardiovascular and cerebrovascular events and all-cause death [D]. Tianjin Medical University, 2017.) It is rarely mentioned, and the current treatment plan and effective drugs for IR in patients with post-stroke muscle spasm have not been reported

Method used

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  • Traditional Chinese medicine composition and application thereof in preparation of drug for treating IR
  • Traditional Chinese medicine composition and application thereof in preparation of drug for treating IR
  • Traditional Chinese medicine composition and application thereof in preparation of drug for treating IR

Examples

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Effect test

Embodiment 1

[0017] 1. Sample selection

[0018] In this example, 156 patients with unilateral upper limb hemiplegia, spasm and pain after stroke were selected from the outpatient and hospitalized Department of Traditional Chinese Medicine of Tongren Hospital Affiliated to Shanghai Jiaotong University School of Medicine from January 2019 to September 2020. They were numbered according to the order of enrollment, and a random sequence was generated with an Excel table, and they were divided into a control group of 76 cases and a treatment group of 80 cases. Limb spasticity assessment standard is based on modified Ash-worth (see literature "Wei Zongyong, Xiao Zhanhong. Feasibility and effectiveness of using physical and mental exercise prescription in stroke rehabilitation [J]. Chinese and Foreign Medical Research, 2019, 17(14): 176- 178", each enrolled case had at least one muscle group spasm degree ≥ 1+ grade spasticity in the affected limb.

[0019] 1.1 Inclusion criteria (meet the follo...

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Abstract

The application provides a traditional Chinese medicine composition and application thereof in preparation of a drug for treating IR and relates to the field of traditional Chinese medicines. The traditional Chinese medicine composition comprises: 30g of raw milkvetch roots, 30g of radix puerariae, 9g of raw radix notoginseng, 9g of rhizoma coptidis, 30g of raw rehmannia roots, 15g of radix angelicae sinensis, 30g of raw white peony roots, 30g of panicled swallowwort roots and 15g of corydalis tubers. The traditional Chinese medicine composition can be applied to preparation of drugs for treating insulin resistance, particularly insulin resistance of post-stroke myospasm sufferers; it is verified that after the composition is taken, motor functions of affected limbs of the post-stroke myospasm sufferer are restored obviously, and fasting blood-glucose, fasting insulin and insulin resistance levels are all improved effectively; and it is confirmed that the traditional Chinese medicine composition can be applied to the preparation of the drugs for treating the insulin resistance of the post-stroke myospasm sufferers.

Description

technical field [0001] The application relates to a traditional Chinese medicine composition, especially the application of the composition in the preparation of medicine for treating IR. Background technique [0002] Insulin resistance (IR for short) refers to the reduction or loss of the responsiveness of the target organs and tissues of insulin to its biological effects, mainly manifested in the weakened ability of insulin to promote the uptake and utilization of glucose in peripheral tissues (fat, muscle tissue) and Decreased efficacy of inhibiting glycogen export (Morita Yutaro, Senokuchi Takafumi, Yamada Sarie, Wada Toshiaki, Furusho Tatsuya, Matsumura Takeshi, IshiiNorio, Nishida Saiko, Nishida Syuhei, Motoshima Hiroyuki, Komohara Yoshihiro & Araki Eiichi (2020). Impact of tissue peripliferation on macrophage systemic insulin resistance in obese mice with diabetes. 8(1):10.1136 / bmjdrc-2020-001578). Its occurrence is related to multiple links and multi-level obstacles...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61P5/50
CPCA61K36/232A61K36/258A61K36/27A61K36/481A61K36/488A61K36/65A61K36/66A61K36/71A61K36/718A61K36/804A61P5/50A61K2300/00
Inventor 蔡之幸陈越胡鹏李丽王阳
Owner SHANGHAI TONGREN HOSPITAL
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