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Application of alpha-mangostin for prevention and treatment of diabetes mellitus

A technique for diabetes and action, which is applied in the field of α-mangostin in the prevention and treatment of diabetes, and can solve problems such as improving diabetes

Inactive Publication Date: 2012-09-19
JILIN AGRICULTURAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no definite report on the effect of Shuangzhu husk extract on diabetes. α, β, γ-mangostin, etc. are the main bivapiram compounds in mangosteen husk, and these substances with clear structures have not been clearly identified. Reports on improving diabetes and its symptoms
Mangosteen husk extract has a certain improvement effect on hyperlipidemia and hypercholesterolemia, but there are few clear literature reports on the effect of α-mangostin in mangosteen husk extract on dyslipidemia caused by high-fat diet

Method used

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  • Application of alpha-mangostin for prevention and treatment of diabetes mellitus
  • Application of alpha-mangostin for prevention and treatment of diabetes mellitus
  • Application of alpha-mangostin for prevention and treatment of diabetes mellitus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0104] Mangosteen was purchased from Carrefour Supermarket, Xintiandi Shopping Center, Changchun City. It was identified as Garcinia mangostana Linn. by Professor Zheng Yinan from the College of Chinese Materia Medica of Jilin Agricultural University. ), take 100g of mangosteen husk powder, flash extraction with 80% ethanol twice, combine the filtrate, and recover the solvent under reduced pressure to obtain the ethanol extract. The ethanol extract is suspended in pure water and extracted with n-butanol to obtain the mangosteen husk The n-butanol extract and the ethanol extract are suspended in pure water and extracted with chloroform to obtain the chloroform extract of mangosteen husk. The n-butanol extract of mangosteen husk was eluted by silica gel column chromatography with chloroform, and purified and separated by repeated column chromatography to obtain 6.70 g of pure α-mangostin product, with a purity of more than 95% as identified by high performance liquid chromatograph...

Embodiment 2

[0106] Hypoglycemic tablets

[0107] Take 2 g of the pure α-mangostin product in Example 1, 20 g of cyclodextrin, an appropriate amount of dried starch, an appropriate amount of carboxymethyl cellulose, an appropriate amount of talc, and an appropriate amount of sucrose. Sucrose and talc are used for sugar coating, mixing, granulation and tableting. The tablet weighs 0.50g and contains 1%-5% (g / g) of α-mangostin. Other requirements comply with the relevant provisions of the 2010 edition of the Pharmacopoeia of the People’s Republic of China on tablets.

Embodiment 3

[0109] Improve glucose tolerance capsules

[0110] Take 1 g of α-mangostin in Example 1, 20 g of corn starch, and appropriate amount of cyclodextrin, mix them, and fill them into capsules, each containing 1-10% (g / g) of α-mangostin. Other requirements are in line with the relevant regulations of the "Pharmacopoeia of the People's Republic of China" 2010 edition on capsules.

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PUM

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Abstract

The invention provides an application of alpha-mangostin for prevention and treatment of diabetes mellitus. Alpha-mangostin can be used for decreasing blood glucose of diabetics, increasing glucose tolerance and improving symptoms of polydipsia, polyuria, polyphagia, emaciation and thirsty of the diabetics, can also be used for lowering high-fat-diet-induced obesity mouse total cholesterol content, has a cholesterol lowering effect, is capable of improving abnormality of the high-fat-diet-induced mouse glucose tolerance, and has functions of preventing and delaying obese patients from getting diabetes mellitus.

Description

Technical field: [0001] The invention relates to the application of α-mangostin in anti-diabetic. α-mangostin has the effects of lowering blood sugar and improving glucose tolerance, and can be used to prevent and treat diabetes and improve its corresponding symptoms. Background technique: [0002] Mangosteen (Garcinia mangostana Linn.) is a plant of the genus Garcinia in the Garcinia family. It is mainly produced in Southeast Asia such as Thailand and Malaysia. It is also introduced in Taiwan, Guangdong and Guangxi, Yunnan and other places. It is a treasure in the fruit, known as the "Queen of Fruit" and "Fruit of God". Mangosteen husk contains a variety of pharmacologically active ingredients, among which difenpyrone is the main active ingredient and research focus. α, β, γ-mangostin, 9-hydroxycalabaxanthone, and 1-isomangostin have been isolated from mangosteen husk. gartanin, 8-desoxygartanin, Garcinone AE and many other diphenylpyrones. Modern scientific research shows tha...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P3/10A61P3/00A61P9/10
Inventor 郑毅男张成中卜其涛刘发贵
Owner JILIN AGRICULTURAL UNIV
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