Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Fructus akebiae extract, preparation and application thereof

A technology of prognostic seed and extract, applied to the preparation of the extract, the field of prognostic seed extract, can solve problems such as hederagenin and its derivatives have not been found, achieve scientific and reasonable extraction steps, controllable quality, impurity low content effect

Active Publication Date: 2011-10-12
兰晟生物医药(苏州)有限公司
View PDF1 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Have not yet found that hedera saponin and its derivatives are used for the preparation of reports of drugs for the treatment of depression

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Fructus akebiae extract, preparation and application thereof
  • Fructus akebiae extract, preparation and application thereof
  • Fructus akebiae extract, preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The Xuanzhizi extract provided in this embodiment is prepared by the following steps: using Xuanzhizi medicinal materials as a raw material, first undergoing degreasing treatment, followed by ethanol extraction, ethyl acetate treatment and water-saturated n-butanol extraction to obtain the total saponin The obtained total saponins are degraded and purified by acid-containing ethanol to obtain an extract of the saponins. The weight percentage of ivy sapogenin in the extracts of the saponins is not less than 60%.

[0034] The preparation method of the above-mentioned predictor extract provided in this embodiment is as follows:

[0035] (1) Degreasing: Take 500g of crude powder of Pregnancy Seed medicinal material, and use 1000ml petroleum ether to ultrasonically degrease for 20-30 minutes;

[0036] (2) After the crude powder of medicinal materials is extracted by ethanol and the petroleum ether is removed by volatilization, ultrasonic extraction is performed twice with 2000ml of...

Embodiment 2

[0047] The Xuanzhizi extract provided in this embodiment is prepared by the following steps: using Xuanzhizi medicinal materials as a raw material, first undergoing degreasing treatment, followed by ethanol extraction, ethyl acetate treatment and water-saturated n-butanol extraction to obtain the total saponin The obtained total saponins are degraded and purified by acid-containing ethanol to obtain an extract of the saponins. The weight percentage of ivy sapogenin in the extracts of the saponins is not less than 60%.

[0048] The preparation method of the above-mentioned predictor extract provided in this embodiment is as follows:

[0049] (1) Degreasing: Take 500g of the crude powder of Zizhizi medicinal materials, and use 1500ml petroleum ether to ultrasonically degrease for 20-30 minutes;

[0050] (2) After the crude powder of medicinal materials is extracted with ethanol and the petroleum ether is removed by volatilization, ultrasonic extraction is performed 3 times with 2500ml ...

Embodiment 3

[0061] For the predictor and its preparation method provided in this embodiment, refer to Embodiment 1 or Embodiment 2.

[0062] The tablet of Yuzhizi extract provided in this embodiment: Use Yuzhizi extract as the active substance, lactose as filler, low-substituted hydroxypropyl cellulose as disintegrant, and magnesium stearate as lubricant, The binder is an ethanol aqueous solution of povidone, wherein the volume concentration of ethanol is 55%, and the volume concentration of povidone is 3.0%.

[0063] The weights of the components are as follows: 200 mg of the extract of Pregnancy, 94 mg of lactose, 4 mg of low-substituted hydroxypropyl cellulose, 2 mg of magnesium stearate, and a total of 300 mg.

[0064] The preparation method of the tablets of the above-mentioned foretell extract is as follows: Weigh the foretell extract, filler and disintegrant in 50 times the prescription amount, pass through a 60-100 mesh sieve at a time, mix well, and use the above-mentioned binder to mak...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an fructus akebiae extract, which is prepared by a method of: taking an fructus akebiae medicinal material as a raw material, performing degreasing treatment first, then orderly performing ethanol extraction, ethyl acetate treatment and water saturated normal butanol extraction to obtain total saponin of fructus akebiae, and performing acid-containing ethanol degradation and purification treatment on the obtained total saponin to obtain the fructus akebiae extract, wherein the weight percentage of hederagenin in the fructus akebiae extract is not lower than 60 percent.The invention also discloses the method for preparing the fructus akebiae extract, a preparation and application thereof. The fructus akebiae extract has the advantages of less impurities, high content of active components, and scientific and reasonable steps; the preparation thereof is safe and effective and has reliable quality; and the fructus akebiae extract and the preparation thereof have good antidepression effect.

Description

Technical field [0001] The present invention relates to an extract of Chinese herbal medicine, in particular to an extract of Pregnancy. The present invention also relates to the preparation and use of the extract. Background technique [0002] Fortune teller, Akebia quinata (Thunb.) Decne., Akebia trifoliata (Thunb.) Koidz. or Akebia trifoliata (Thunb.) Koidz.Var.australis (Diels) Rehd. Dry nearly mature fruit. Distributed in Jiangsu, Hunan, Hubei, Sichuan, Zhejiang, Anhui and other provinces in my country. The effect is to soothe the liver and regulate qi, promote blood circulation and relieve pain, diuresis, and kill insects. Used for abdominal pain, amenorrhea, dysmenorrhea, poor urination, snake and insect bites. Among them, Akebin A, B, C, D, E, F and G are mainly contained, and the sapogenins are all hederogenin. According to the "Compendium of Materia Medica·Caobu (Part 2)", the precepts of the pre-zhizi group treat "lack of energy, trance, language errors, palpitatio...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61P25/24A61K131/00
Inventor 徐江平
Owner 兰晟生物医药(苏州)有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com