510 results about "Epileptic convulsions" patented technology

Preparations and extracts of valerian, as well as isovaleramide, isovaleric acid, and certain structurally related compounds exhibit clinically significant pharmacological properties which implicate a treatment for a variety of pathological conditions, including spasticity and convulsions, which are ameliorated by effecting a modulation of CNS activity. The compositions in question generally are non-cytotoxic and do not elicit weakness or sedative activity at doses that are effective for the symptomatic treatment of such pathological conditions.

The present invention includes a transdermal composition which contains a pharmaceutically effective amount of a cannabinoid for delivery of the cannabinoid to the bloodstream of a user. The composition may comprise the following components: a surfactant-lecithin organogel; and a cannabinoid. The composition may also comprise an exogenous terpene. The cannabinoid is capable of diffusing from the composition into the bloodstream of the user, and may be used in methods for treating a patient suffering from a condition such as pain, nausea and emesis, convulsions, muscle spasm, inflammation, depression, and cachexia.

Methods of treating or preventing chronic pain or convulsion are disclosed by administering to an animal a sodium channel blocker and at least one of gabapentin and pregabalin. Also disclosed are pharmaceutical compositions and kits for the treatment or prevention of chronic pain or convulsion.

The invention discloses a bionic enzymatic product of horns and application thereof, which belong to the field of Chinese medicament. The bionic enzymatic product is characterized in that a bionic enzymatic method is adopted, and comprises the following steps: taking horns; grinding the horns into fine powders; adding water into the fine powders; evenly stirring the mixture; under appropriate condition, performing heat preservation by using pepsin; performing heat preservation by using pancreatin or trypsase; and preparing obtained zymolyte into preparations according to different preparationrequirements. The product of the invention has good effects in the aspects of clearing away heat and toxic material, cooling blood and hemostasis, diminishing inflammation, resisting infection and virus, arresting convulsion, and easing pain.

The invention reveals that endogenous cholesterol metabolic product cholestane-3 beta, 5 alpha, 6 beta-triol (YC-5) has protection function for neuronal damage caused by cerebral ischemia, ischemia ofspinal cord, epileptic seizure and convulsion and relates to an application of YC-5 in preparation of neuronal protection medicine. The YC-5 can be prepared from cholesterol through two steps. The primitive cell culture in vitro and spinal cord ischemia animal model proves that YC-5 has protection function for neuronal damage caused by cerebral ischemia, ischemia of spinal cord, epileptic seizureand convulsion. YC-5 in effective dose has no toxic and side reactions. YC-5 is an effective neural protectant which aims to multiple molecular mechanism and cures cerebral ischemia damage, spinal cord ischemia damage, epileptic seizure and convulsion.

Methods of treating or preventing an amyloid-related disease in a subject by administering to a subject a therapeutic amount of a compound of the invention are described. Also included are methods for inhibiting epileptogenesis in a subject, by administering to a subject an effective amount of an anti-epileptogenic agent. Methods for treating a subject suffering from an epileptogenesis-associated condition, by administering to the subject an effective amount of an anti-epileptogenic agent are also included. Methods for treating convulsions in a subject by administering to the subject an effective amount of a therapeutic amount of a compound of the invention are also described.

The present invention provides a helicid powder injection and its preparation method. Every powder injection contains 25-600 mg of helicid, and the rest is medicinal auxiliary material for injection. It has good stability, can be stored for 3 years at normal temperature, its irritation is small, and its injection site has no clear change or light hyperemia, and its sedation effect is good, and its convulsion-resisting action is strong, it can obviously reduce coriamyrtin convulsion incidence rate, prolong generative latent period, reduce frequency of attack and shorten time and process of attack. The tests show that said helicid powder injection has the strong action of stopping pain and relieving inflammation.

The present invention provides a helical soft capsule. Every capsule contains 5-200mg of helical, the rest is solvent matrix, the described solvent matrix is one of PEG 300-1000, propylene alcohol, soybean oil and peanut oil or their composition. According to the requirements the medicinal color matter and flavor agent can be added into its liquid medicine. Said invented soft capsule has the sedation, can obviously reduce coriamyrtin convulsion incidence rate, prolong its generative latent period, reduce frequency of attack and shorten the time and process of attack, and has the actions of stopping pain and resisting inflammation, and has a certain action of relieving vasoconstriction and raising oxygen consumption of heart muscle, and its biological utilization rate can be raised by 10-59%.

The invention provides a myoelectric signal-controlled master-slave wireless functional electric stimulation rehabilitation system in the technical field of rehabilitation medical treatment. The system comprises a master unit and a slave unit, wherein the master unit is connected with a master side to transmit myoelectric information; the master unit is in wireless connection with the slave unit to transmit motion mode information; and the slave unit is connected with a slave side to transmit electrical pulse information. The master unit comprises a plurality of EMG electrode plates, an amplifier, a filter, an encoder and a wireless transmitter; and the slave unit comprises a wireless receiver, a controller, an electrical stimulator and a plurality of FES electrode plates. By using the system, a physical therapist assists a paralyzed patient to do training without physical contact, and a plurality of patients can do rehabilitation trainings following the same physical therapist, so the workload of the physical therapist is greatly lightened; meanwhile, the system can keep the muscle vitality of the patient, prevent muscular atrophy, reduce convulsion and help the patient achieve more ideal rehabilitation effect.

The invention relates to novel quinazolines and heterocycles which are antagonists or positive modulators of AMPA receptors, and the use thereof for treating, preventing or ameliorating neuronal loss associated with stroke, global and focal ischemia, CNS trauma, hypoglycemia and surgery, as well as treating or ameliorating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, Parkinson's disease and Down's syndrome, treating, preventing or ameliorating the adverse consequences of the overstimulation of the excitatory amino acids, treating, preventing or ameliorating anxiety, psychosis, convulsions, chronic pain, glaucoma, retinitis, urinary incontinence, muscular spasm and inducing anesthesia, as well as for treating or ameliorating the adverse consequences of excitatory amino acid deficiency such as schizophrenia, myoclonus. Alzheimer's disease and malnutrition and neural maldevelopment, and as cognition and learning enhancers.

The present invention relates to an improved extract of Scutellaria lateriflora, a method of preparing the same, and a pharmaceutical composition prepared from the present extract suitable for treating anxiety, insomnia, convulsions, muscle tension and spasm, and related manifestations and disorders in humans and other mammals.The invention also relates to an improved method of treating anxiety, insomnia, convulsions, muscle tension and spasm, and related manifestations and disorders in humans and other mammals by administering the improved extract of Scutellaria lateriflora.

The invention relates to a novel piperazinoamide compound, a preparation method thereof, and application thereof in treating neurodegenerative disease, mental disease, epilepsy, convulsion, apoplexy, and the like. The structure of the piperazinoamide compound is shown as formula I. The in vitro tests verify that the piperazinoamide compound has an effect of inhibiting cells BV2 from secreting IL-1beta effectively, and has high safety. The formula I is shown in the description.

The invention relates to a medicament for treating anhypnia, which comprises the following raw medicines: spina date seed, semen boitae, nacre mother of pearl, tuber fleeceflower stem, uncaria, flower of silktree albizzia, Indian bread with pine, polygala root, keel, the fruit of Chinese magnoliavine, rehmannia root, Poria cocos, crude Chinese yam, prepared Astragalus membranaceus and liquorice; and the raw materials are prepared into capsules by adding water the raw medicines, decocting, taking decoction, concentrating and drying. The medicament disclosed by the invention has the functions of nourishing kidneys and calming hearts, calming nerves and benefiting intelligence, arresting convulsion and improving eyesight, nourishing spleens and stomachs, clearing heat and calming livers and tonifying qi and nourishing middle-Jiao. Tested by clinic, the medicament for treating anhypnia has the advantages of good curing effect on anhypnia and no toxic and side effects.

The invention discloses application of eucommia ulmoides extracts in the preparation of compositions for tranquilizing and inducing sleep and application of the eucommia ulmoides extracts in the preparation of compositions for treating insomnia, anxiety neurosis or convulsion. The eucommia ulmoides extracts are continuously extracted from eucommia bark, eucommia leaves, eucommia male flowers and\or eucommia whole plants by petroleum ether, ethyl acetate, normal butanol, ethanol and water. The eucommia ulmoides extracts are obtained by extracting from eucommia plants. And results of researcheson the application of the eucommia ulmoides extracts in the field of tranquilization and sleep induction show that the eucommia ulmoides extracts have remarkable effects of tranquilizing and inducingsleep and resisting convulsion, wherein the ethyl acetate extract of eucommia and the normal butanol extract of the eucommia have more obvious effects. The eucommia ulmoides extracts are natural active materials for researching and developing novel health-care foods and new drugs for tranquilizing and inducing sleep, and can be applied to the treatment of nervous system diseases such as insomnia,anxiety neurosis and convulsion without side effects and psychic dependence.

A compound represented by the formula (I):or a pharmaceutically acceptable salt thereof, wherein:R1 represents a branched lower alkyl group having from 3 to 9 carbon atoms or the like;R2 represents a 6-membered heteroaryl group having 1 or 2 nitrogen atoms or the like;R3 represents a hydrogen atom, an alkanoylamino group or the like;R4 represents a hydrogen atom, a lower alkyl group or the like;X1 represents an oxygen atom or a sulfur atom;X2 represents an oxygen atom or a single bond; andm indicates an integer of from 0 to 4.This compound has a metabotropic glutamate receptor 1 inhibitory effect, and therefore is useful for the treatment of a brain disorder such as convulsion, acute pain, inflammatory pain, chronic pain, cerebral infraction or transient cerebral ischemic attack, a mental dysfunction such as schizophrenia, and a disease such as anxiety and drug addition.

Tannate compositions containing active pharmaceutical ingredients to be used for treating nausea, vomiting, pain, convulsions, and insomnia and manufacturing processes for preparing the tannate compositions.

The invention belongs to a healthy protection wine, which is composed of notopterygium root, radix sileris, angelica, cassia twig, achyranthes, teasel root, wild celery, asarum, prepared rhizome of adhesive rehmannia, tuckahoe, radix codonopsitis, coix seed, qinjiu, hemlock parsley, eucommia bark, root of herbaceous peony, astragalus root, liquorice, lycopodium calvatum, Stringy Stonecrop Herb, Gambir Plant, pawpaw and xungufeng; and the above materials are smashed and dipped in high purity wine to prepare the healthy wine. The wine has functions of supplementing qi and nourishing Blood, removing rheumatism, strengthening bones and muscles, relieving convulsion, inducing diaphoresis, expelling wind and relieving convulsion, clearing away heat to stop liver, sumplementing qi and generating yang, strengthening exterior and reducing sweat, promoting urination and reducing swelling, strengthening the middle Burner and replenishing qi, promoting fluid and benefiting blood, activate yang converting qi, removing stasis and adjusting menstruation, activating articulation, nourishing liver and kidney, and cycling blood, and the wine can regulate the internal secretion from various reaspects; and improve radically human body unity and can supply nourishment reasonably; thus having special effect for curing the rheumatism and rheumatoid disease, lumbar disc herniation, arthritis, sciatica, vasculitis, impotence and cardiovascular and cerebrovascular disease.

The present invention relates to propofol derivatives comprising a cyclic or linear amino acid, or a poly- or (oligo)saccharide moiety, a process for preparing said derivatives, a method for anesthetizing a mammal as well as a method for treating convulsions, migraine or related diseases, or for the inhibition of free radicals in a mammal to which said compounds are administered. Furthermore, the present invention relates to said compounds for use as a medicament and the use of said compounds for the preparation of a medicament for anesthetizing a mammal or for treating convulsions, migraine or related diseases, or for inhibition of free radicals in a mammal.

The invention relates to BCAT inhibitors and the use thereof for treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease and Down's syndrome, treating or preventing the adverse consequences of the overstimulation of the excitatory amino acids, treating anxiety, psychosis, convulsions, aminoglycoside antibiotics-induced hearing loss, migraine headache, chronic pain, neuropathic pain, Parkinson's disease, diabetic retinopathy, glaucoma, CMV retinitis, urinary incontinence, opioid tolerance or withdrawal, and inducing anesthesia, as well as for enhancing cognition.

The invention discloses fructus akebiae healthy tea which is prepared from fructus akebiae,narrow-leaved oleaster fruit, marigold, green alectoria filament, rhodobryum giganteum, and Siberian nitrari in a certain weight proportion. The healthy tea has the purposes of dispersing the liver depression, promoting blood circulation to stop pain, tranquilizing and allaying excitement, relieving heart to treat eye disease, and strengthening by means of tonics. Owing to low cost, good effect, reasonable formula, easy preparation, simple preservation, being suitable for four seasons, curing diseases and protecting health, convenient drinking and good taste, the healthy tea is applicable to those who suffer from diseases such as liver and stomach pains due to disorder of qi, stomach heat and poor appetite, dyspepsia, soothing liver and tonifying kidney, strengthening spleen and stomach, invigorating spleen and stomach, body weakness, cough due to lung-heat, dizziness and blurred vision, infantile convulsion, cold and cough, neurasthenic, body emaciation, deficiency of both qi and blood, dyspepsia, abnormal menstruation, etc., on which the healthy tea performs good effects. The fructus akebiae healthy tea is an ideal healthy drink.

The invention discloses a preparation method of an ultramicro gastrodia elata decoction piece. The preparation method comprises selection of raw materials, cleaning of the raw materials, boiling, slicing, secondary boiling, drying, ultramicro wall breaking, obtaining of a preparation, and the like. Gastrodia elata processed by employing the processing and ultramicro fragmentation method has relatively high effective-composition dissolution rate, the bioavailability of a medicine is improved, the medicine effect is relatively good, and the toxicity is relatively low. The invention also discloses the decoction piece prepared by employing the method, and application of the decoction piece to prepare medicines for treating headache dizziness, numbness of limbs, infantile convulsion, epilepsy, twitch, tetanus and other diseases.

The invention discloses a far-infrared ceramic ball and a preparation method thereof. The far-infrared ceramic ball comprises the following raw materials in parts by weight: 65-85 parts of loess stone, 40-60 parts of medical stone, 25-45 parts of hexacyclic stone, 18-26 parts of stone needle, 10-15 parts of malthacite, 12-16 parts of bamboo charcoal powder, 8-14 parts of actinolite, 5-10 parts of pitchstone, 10-15 parts of muyu stone, 6-12 parts of vermiculite, 4-8 parts of nanometer zinc oxide, 16-22 parts of moire stone, and 14-18 parts of attapulgite. The far-infrared ceramic ball provided by the invention can emit far infrared rays of which wavelength is 4-16 microns, the emission rate is more than 90%, and the efficacy is long-lasting at room temperature, can effectively destroy a hydrogen bond between water molecules so as to reduce the degree of association between the water molecules and generate small molecular grouping water to improve penetration of drinking water, and can dissolve out macroelements such as potassium, sodium, calcium, magnesium and phosphorus as well as microelements such as zinc, iron, lithium, iodine and selenium, which are essential elements of a human body; efficacies of warming the kidney and tonifying Yang, relieving convulsion and calming the nerves, and removing nebula and improving eyesight can be realized after water which soaked with the far-infrared ceramic ball is drank for a long time.

Disclosed are A3 adenosine receptor antagonists and / or partial agonists and A1 adenosine receptor agonists and / or partial agonists of formula (I):wherein R1 to R5 are as described herein, as well as pharmaceutical compositions thereof and methods of use thereof. The A3 AR antagonists or partial agonists find use in treating a number of diseases such as cancer, glaucoma, and inflammatory diseases, as well as in preventing cardiac ischemia. Also disclosed are radiolabeled compounds of formula (I) and the use thereof in diagnostic imaging of tissues and organs. The A1 AR agonists and partial agonists find use in treating diseases such as seizures, convulsion, stroke, diabetes, pain, arrhythmias, depression, and anxiety and in cardioprotection or neuroprotection.

The invention discloses an externally-used plaster for treating infantile febrile convulsion. The externally-used plaster is characterized in that bulk pharmaceutical chemicals of the formula weight are grinded into powder, then wine with the alcoholic strength lower than 40 degrees is slowly dropped into the medicine powder to stir the medicine into paste while the wine is dropped. The bulk raw materials comprises by weight proportion: 0.5-2 parts of amber, 2 parts of pearl, 1 part of bezoar, 1 part of rhinoceros horn, 1 part of stiff silkworm, 1 part of periostracum cicada, 1 part of bulbus fritilariae, 1 part of pericarpium citri reticulatae, 0.5-1 part of bryozoatum, 2 parts of fructus piperis alba, 0.5-2 parts of fructus evodiae or 0.5-2 parts of concretio silicea bambusae and / or 0.5-2 parts of arisaema cum bile, 2 parts of sticky rice, 0.5-2 parts of jasmine or 0.5-2 parts of rheum officinale and 0.5-2 parts of uncaria rhynchophylla or 0.5-2 parts of gastrodia elata. The externally-used plaster for treating infantile febrile convulsion is good in effect of preventing and treating infantile convulsion, free of side and toxic effects, wide in medicine source and moderate in cost, has the effect of wind dispelling, resuscitation inducing, dizziness relieving, convulsion relieving, tranquilizing and excitement allaying, phlegm cleansing and spasmolysis, and is suitable for children patients, and the cure rate is as high as 95%.

The present invention discloses a medical composition comprising effective amount of otilonium Br for treating irritable bowel syndrome or stomach convulsion. Said composition will disperse into small granules within five minutes in water and the in vitro dissolve-out will be above 90%, which will hence dispel the convulsion rapidly. The preferred composition is of capsule type.

The invention discloses traditional Chinese medicine heal-care tea with the effects of moistening lung and lowering blood pressure, overcoming the defects of poor taste and unobvious blood pressure lowering effect of the traditional Chinese medicine heal-care tea in the prior art. The traditional Chinese medicine heal-care tea comprises the following Chinese medical herbs: chrysanthemums, apocynum venetum, selfheal, honey mulberry leaves, gynostemma pentaphyllum, lofty wallich wedelia herbs, ligusticum wallichii, lofty hedgehog hydnum, lofty hawthorns, and the like. A preparation method of the traditional Chinese medicine heal-care tea comprises the following steps of: mixing the Chinese medical herbs and then grinding or respectively grinding the Chinese medical herbs and then mixing; carrying out germicidal treatment; and placing into a brewing bag made of tea filter paper for brewing drinking. The selected raw Chinese medical herbs jointly act and have the effects of clearing heat and moistening the lung, activating blood and dissolving stasis and obviously lowering blood pressure ; and in addition, after the traditional Chinese medicine heal-care tea is drunk for a long time, symptoms, i.e. giddiness, headaches, dizziness, insomnia, frightened epilepsy, convulsion, and the like which are caused by blood pressure diseases, are obviously relieved or dispelled.

Disclosed herein is a transnasal anticonvulsive pharmaceutical composition comprising diazepam as an active ingredient, water, a fatty acid ester, diethylene glycol monoethyl ether, ethanol and sodium glycocholate, wherein the weight of the fatty acid ester is at least 2-fold higher than that of water and is at least 2-fold higher than that of ethanol.The anticonvulsive pharmaceutical composition for transmucosal delivery of diazepam according to the present invention includes a minimized content of water and ethanol, a fatty acid ester as a main ingredient and no use of a polar solvent, e.g. glycol, and, exhibits improved diazepam solubility and transmucosal permeability due to using a small amount of water and ethanol. The present invention also includes treatment of convulsions by transnasally administering to a patient in need thereof a therapeutically effective amount of the disclosed compositions.

The invention discloses a Chinese medicinal composition for treating meniere disease and a preparation method of the Chinese medicinal composition. The Chinese medicinal composition comprises the following components in parts by weight: 25-45 parts of medcinal evodia fruits, 25-45 parts of cassia twig, 20-40 parts of white paeony roots, 20-40 parts of prepared common monkshood daughter roots, 15-30 parts of bighead atractylodes rhizomes, 15-30 parts of poria cocos, 15-30 parts of dark plum fruits, 8-20 parts of immature bitter oranges, 6-18 parts of kudzuvine roots, 3-12 parts of nacre, 6-15 parts of Chinese-dates, 5-15 parts of szechuan lovage rhizomes, 4-12 parts of tangerine peels and 2-10 parts of honey-fried licorice root. The Chinese medicinal composition can be prepared into any clinically acceptable medicine preparation by a conventional preparation method of Chinese medicines. The Chinese medicinal composition has functions of soothing the nerves and arresting the convulsion, warming the channels to smoothen the pulse and soothing the nerves and developing the intelligent. The clinical curative effect shows that the Chinese medicinal composition is precise and reliable in curative effect of the meniere disease, and safe in clinical application, and has a function of treating both manifestation and root cause of disease and no side toxic or side effects.

The present invention belongs to the field of Chinese medicine technology, and especially a kind of compound Chinese medicine tablet for treating epilepsia, infantile convulsion and facial spasm and its preparation process.