Application of eucommia ulmoides extracts

Abstract

The invention discloses application of eucommia ulmoides extracts in the preparation of compositions for tranquilizing and inducing sleep and application of the eucommia ulmoides extracts in the preparation of compositions for treating insomnia, anxiety neurosis or convulsion. The eucommia ulmoides extracts are continuously extracted from eucommia bark, eucommia leaves, eucommia male flowers and\or eucommia whole plants by petroleum ether, ethyl acetate, normal butanol, ethanol and water. The eucommia ulmoides extracts are obtained by extracting from eucommia plants. And results of researcheson the application of the eucommia ulmoides extracts in the field of tranquilization and sleep induction show that the eucommia ulmoides extracts have remarkable effects of tranquilizing and inducingsleep and resisting convulsion, wherein the ethyl acetate extract of eucommia and the normal butanol extract of the eucommia have more obvious effects. The eucommia ulmoides extracts are natural active materials for researching and developing novel health-care foods and new drugs for tranquilizing and inducing sleep, and can be applied to the treatment of nervous system diseases such as insomnia,anxiety neurosis and convulsion without side effects and psychic dependence.

Description

technical field

[0001] The invention relates to the application of an extract of Eucommia ulmoides. Background technique

[0002] Insomnia is a clinical frequently-occurring disease with complex etiology and easy recurrence. The sedative-hypnotics of western medicine and western medicine commonly used for domestic and international treatment all have certain side effect and dependence at present. The sedative and hypnotic effect of traditional Chinese medicine has become a hot research topic in recent years.

[0003] Eucommia ulmoides Oliv., a deciduous tree belonging to the genus Pinaceae; the branchlets are smooth, yellowish-brown or light, with flaky pith, and the bark, branches and leaves all contain gelatin; the leaves are alternate, oval or egg-shaped Shaped, apex acuminate, base broadly cuneate, margins serrated, young leaves sparsely pubescent on top, densely hairy below, smooth above older leaves, sparsely pubescent on the lower veins; flowers unisexual, dioecious...

Examples

Embodiment 1

[0029] Example 1 Study on the hypnotic and sedative activity of continuous extracts of Eucommia ulmoides:

[0030] 1. Materials and methods

[0031] 1.1 Main materials and reagents

[0032] Eucommia: obtained from the planting base of Eucommia in XX County, XX City; pentobarbital sodium, a subpackaged product of Sigma Company in Shanghai; nikethamide, 0.9% sodium chloride solution, diazepam, from Shanghai Shiyi Chemical Reagent Co., Ltd.

[0033] 1.2 Main instruments and equipment

[0034] GJ-1 type photoelectric counter, Tianjin Medical Equipment Repair Factory.

[0035] 1.3 Test animals

[0036] Kunming white mice, common grade, 20-30 g (male), were provided by the Animal Experiment Center of Henan University of Science and Technology.

[0037] 2. Test method

[0038] 2.1 Effects on autonomous activities of mice:

[0039] Animal grouping: Before the experiment, put the mice into the activity box of the GJ-1 photoelectric counter, start the recorder to record the number...

Embodiment 2

[0073] The preparation of embodiment 2 health care medicinal tea:

[0074] Take 3 grams of Eucommia ulmoides ethyl acetate extract or eucommia n-butanol extract, add 50 kg of tea leaves (choose one from black tea, green tea and scented tea), mix evenly, and transfer to a pulverizer to make the particle size of the material 15-30 mesh , add 47 kilograms of compound sweeteners, put into special paper bubble bag after mixing thoroughly, outerwear aluminum-plastic composite bag, seal, every bag 5-8 gram, make the calm hypnotic health care tea of ​​bagging.

Embodiment 3

[0075] The preparation of embodiment 3 health-care granules:

[0076] Take Eucommia ulmoides ethyl acetate extract or eucommia n-butanol extract, mix with appropriate amount of fruit juice powder, sugar and other auxiliary agents, pass through a 12-mesh sieve, dry at 75°C, pack into bags, and make various granules with sedative and hypnotic effects , Each bag contains 100 mg of Eucommia extract.

technical field

[0001] The invention relates to the application of an extract of Eucommia ulmoides. Background technique

[0002] Insomnia is a clinical frequently-occurring disease with complex etiology and easy recurrence. The sedative-hypnotics of western medicine and western medicine commonly used for domestic and international treatment all have certain side effect and dependence at present. The sedative and hypnotic effect of traditional Chinese medicine has become a hot research topic in recent years.

[0003] Eucommia ulmoides Oliv., a deciduous tree belonging to the genus Pinaceae; the branchlets are smooth, yellowish-brown or light, with flaky pith, and the bark, branches and leaves all contain gelatin; the leaves are alternate, oval or egg-shaped Shaped, apex acuminate, base broadly cuneate, margins serrated, young leaves sparsely pubescent on top, densely hairy below, smooth above older leaves, sparsely pubescent on the lower veins; flowers unisexual, dioecious...

Examples

Embodiment 1

[0029] Example 1 Study on the hypnotic and sedative activity of continuous extracts of Eucommia ulmoides:

[0030] 1. Materials and methods

[0031] 1.1 Main materials and reagents

[0032] Eucommia: obtained from the planting base of Eucommia in XX County, XX City; pentobarbital sodium, a subpackaged product of Sigma Company in Shanghai; nikethamide, 0.9% sodium chloride solution, diazepam, from Shanghai Shiyi Chemical Reagent Co., Ltd.

[0033] 1.2 Main instruments and equipment

[0034] GJ-1 type photoelectric counter, Tianjin Medical Equipment Repair Factory.

[0035] 1.3 Test animals

[0036] Kunming white mice, common grade, 20-30 g (male), were provided by the Animal Experiment Center of Henan University of Science and Technology.

[0037] 2. Test method

[0038] 2.1 Effects on autonomous activities of mice:

[0039] Animal grouping: Before the experiment, put the mice into the activity box of the GJ-1 photoelectric counter, start the recorder to record the number...

Embodiment 2

[0073] The preparation of embodiment 2 health care medicinal tea:

[0074] Take 3 grams of Eucommia ulmoides ethyl acetate extract or eucommia n-butanol extract, add 50 kg of tea leaves (choose one from black tea, green tea and scented tea), mix evenly, and transfer to a pulverizer to make the particle size of the material 15-30 mesh , add 47 kilograms of compound sweeteners, put into special paper bubble bag after mixing thoroughly, outerwear aluminum-plastic composite bag, seal, every bag 5-8 gram, make the calm hypnotic health care tea of ​​bagging.

Embodiment 3

[0075] The preparation of embodiment 3 health-care granules:

[0076] Take Eucommia ulmoides ethyl acetate extract or eucommia n-butanol extract, mix with appropriate amount of fruit juice powder, sugar and other auxiliary agents, pass through a 12-mesh sieve, dry at 75°C, pack into bags, and make various granules with sedative and hypnotic effects , Each bag contains 100 mg of Eucommia extract.

Images