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Helicid soft capsule and its preparation method

A technology of tofu fruit glycosides and soft capsules, which is applied in capsule delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., and can solve problems such as poor bioavailability, poor bioavailability of glycosides, and poor water solubility. To achieve the effect of improving bioavailability, improving bioavailability and reducing incidence

Inactive Publication Date: 2004-10-13
KUNMING ZIJIAN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the relatively poor water solubility of tofu fruit glycosides, it dissolves in hot water and becomes a paste-like insoluble matter after cooling, and the bioavailability of glycosides is generally poor. Studies have shown that the bioavailability of common oral preparations of tofu fruit glycosides is poor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Prescription (1000 capsules):

[0049] Tofu fructose 25g

[0050] PEG-400 100g

[0051] It is prepared by the following method: first, dissolve bean curd with PEG with higher polarity or smaller molecular weight as much as possible, then add it into other solvent matrix, fully stir, dissolve, filter, degas, and send it to the tank above the filling machine , stand-by; at the same time, prepare the gelatin solution for the rubber skin in the insulating gelatin tank above the soft capsule filling machine, and stand-by; under the conditions of 10,000 grade, 21 ℃ ~ 25 ℃, RH%: 39 ~ 41%, start the rotation Press the pills with a molding machine, wash the prepared soft capsules, dry at 28±2° C. for 19-27 hours, sub-pack and pack to obtain the finished soft capsules each containing 25 mg of tofu fructose.

Embodiment 2

[0053] According to the following prescription, and use the method of embodiment 1 to make every 1000 soft capsule finished products containing bean curd 5mg:

[0054] Tofu fructose 5g

[0055] PEG-400 50g

[0056] Soybean Oil 10g

[0057] Propylene glycol 25g.

Embodiment 3

[0059] According to the following prescription, and use the method of embodiment 1 to make every 1000 soft capsule finished products containing bean curd 200mg:

[0060] Tofu fructose 200g

[0061] PEG-400 350g

[0062] PEG-300 210g

[0063] Propylene glycol 100g.

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PUM

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Abstract

The present invention provides a helical soft capsule. Every capsule contains 5-200mg of helical, the rest is solvent matrix, the described solvent matrix is one of PEG 300-1000, propylene alcohol, soybean oil and peanut oil or their composition. According to the requirements the medicinal color matter and flavor agent can be added into its liquid medicine. Said invented soft capsule has the sedation, can obviously reduce coriamyrtin convulsion incidence rate, prolong its generative latent period, reduce frequency of attack and shorten the time and process of attack, and has the actions of stopping pain and resisting inflammation, and has a certain action of relieving vasoconstriction and raising oxygen consumption of heart muscle, and its biological utilization rate can be raised by 10-59%.

Description

technical field [0001] The invention relates to a biologically active tofufucoside soft capsule and a preparation method thereof, which belong to medicines. Background technique [0002] Tofu Fructoside (Hilieidum), also known as Kunming Shenshuiguosu, Shenshuiguosu, etc., is a natural plant monomer component extracted and isolated from the fruit of Helicia erratica Hock. So far this product is only one tablet. Tofu pectin tablets have been used clinically for 20 years and are currently the main drug used for sedation and sedation. Due to the relatively poor water solubility of tofufructin, it dissolves in hot water and becomes a paste-like insoluble substance after cooling, and the bioavailability of glycosides is generally poor. It cannot meet the needs of some special patients. SUMMARY OF THE INVENTION [0003] The object of the present invention is to overcome the above-mentioned problems existing in the existing tofufucoside, and to provide a softcapsule of tofufuc...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/7048A61P25/20
Inventor 赵勇
Owner KUNMING ZIJIAN BIOTECH
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