Helicid powder injection preparation and its preparation method

A technology of tofu glucoside powder and tofu glucoside, which is applied in the field of medicine and medicine, can solve the problems of inconvenient use and poor curative effect, and achieve the effect of reducing the degree of seizures, reducing the number of seizures, and good stability

Inactive Publication Date: 2004-10-13
KUNMING ZIJIAN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the poor water solubility of tofu fruit glycosides, and the current dosage is also small, this product is inconvenient to use and has poor curative effect. Especially for some special patients and critical emergency patients, injections that are quick to take effect and easy to use are needed. Carry out rescue or treatment to meet the needs of curing diseases and saving lives

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] 1. Tofu glucoside freeze-dried powder injection (1000 sticks)

[0058]formula:

[0059] Tofu fruit glycosides 25g

[0060] Mannitol 100g

[0061] Preparation Process:

[0062] Under the condition of grade 10,000, first dissolve mannitol in 1500ml of water for injection at 70°C, then add 25g of tofu fruit glucoside, and pay attention to make it dissolve completely, adjust isotonicity, and add water for injection to 2000ml. Insulation and filtration, the filtrate is treated with filter paper and 0.4μm filter membrane, and then filtered with a filter membrane below 0.2μm under the condition of 100 grades. The fine filtrate is sent to the packing machine, packed according to 2ml per bottle, covered with a slotted lid, sent to the freeze vacuum dryer, quickly cooled to ~-40 ° C, 2 to 3 hours, and gradually warmed to ~ 40 ° C (about takes 10 hours). Tighten the cover, take out the finished product, tie the cover, pack, inspect, and pass the finished product. 1,000 stick...

Embodiment 2

[0064] According to the following formula, and use the preparation method of embodiment 1 to make 1000 sticks of tofu fruit glycoside powder injection finished products of the specification of 100mg:

[0065] Tofu fruit glycosides 100g

[0066] Mannitol 100g

[0067] Glycine 5g.

Embodiment 3

[0069] According to the following formula, and use the preparation method of embodiment 1 to make 1000 sticks of tofu fruit glycoside powder injection finished product of the specification of 200mg:

[0070] Tofu fruit glycosides 200g

[0071] Mannitol 180g

[0072] Glucose 60g.

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PUM

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Abstract

The present invention provides a helicid powder injection and its preparation method. Every powder injection contains 25-600 mg of helicid, and the rest is medicinal auxiliary material for injection. It has good stability, can be stored for 3 years at normal temperature, its irritation is small, and its injection site has no clear change or light hyperemia, and its sedation effect is good, and its convulsion-resisting action is strong, it can obviously reduce coriamyrtin convulsion incidence rate, prolong generative latent period, reduce frequency of attack and shorten time and process of attack. The tests show that said helicid powder injection has the strong action of stopping pain and relieving inflammation.

Description

technical field [0001] The invention relates to a biologically active bean curd glucoside powder injection and a preparation method thereof, belonging to pharmaceuticals. Background technique [0002] Hilieidum, also known as Kunming Shenshuiguosu, Shenshenguosu, etc., is a natural plant monomer component extracted from the fruit of Yunnan Jingpo medicine Muza (Helicia erratica Hock.F). So far this product has only one tablet. Tofu fruit glycoside tablets have been clinically used for 20 years and are currently the main drug used for calming and sedating. Due to the poor water solubility of tofu glucoside and the current dosage is relatively small, this product is inconvenient to use and the curative effect is poor, especially for some special patients and critical emergency patients, an injection that takes effect quickly and is convenient to use is required Carry out rescue or treatment to meet the needs of curing diseases and saving lives. Contents of the invention ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/7048A61P25/20
Inventor 余娟
Owner KUNMING ZIJIAN BIOTECH
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