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Bionic enzymatic product of horns and application thereof

A technology of enzymatic hydrolysis products and bionic enzymolysis, which is applied in the direction of medical preparations containing active ingredients, drug combinations, blood diseases, etc., can solve the problems of less absorption and utilization of active ingredients, waste and reduction of medicinal materials, etc.

Inactive Publication Date: 2010-02-17
北京凯瑞创新医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional raw powder is taken directly. Only a small amount of macromolecular protein in the raw drug powder is decomposed in the gastrointestinal tract in the body and becomes small molecular oligopeptides to be absorbed. The interference of oral administration of other foods results in incomplete hydrolysis, less active ingredients are absorbed and utilized, resulting in a waste of a large amount of medicinal materials and a greatly reduced curative effect
The extraction process of water extraction makes most of the protein insoluble in water removed by filtration, resulting in a lot of waste of medicinal materials, and the curative effect is also greatly reduced

Method used

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  • Bionic enzymatic product of horns and application thereof
  • Bionic enzymatic product of horns and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0129] Take 500g of goat horns, crush them into fine powder, add 10 times the amount of water to homogenate, adjust the pH to 2.0, add 1% of the amount of goat horns with pepsin, incubate at 40°C for 2 hours, adjust the pH to 8.0, add goat horns A certain amount of 1% trypsin was incubated at 50° C. for 4 hours, spray-dried, added an appropriate amount of starch, granulated, dried, sized, and filled into capsules.

Embodiment 2

[0131] Take 500g of yak horns, crush them into fine powder, add 8 times the amount of water to homogenate, adjust the pH to 2.6, add 2% of the amount of yak horns with pepsin, incubate at 37°C for 3 hours, adjust the pH to 7.5, add yak horns A certain amount of 2% trypsin was incubated at 40° C. for 6 hours, spray-dried, added an appropriate amount of microcrystalline cellulose, granulated, dried, sized, and pressed into tablets.

Embodiment 3

[0133] Take 500g of antelope horns, crush them into fine powder, add 15 times the amount of water to homogenate, adjust the pH to 3.0, add 5% of the antelope horns pepsin, keep it at 40°C for 2 hours, adjust the pH to 8.5, add antelope horns The amount of 5% trypsin was incubated at 45°C for 5 hours, heated to 85°C and incubated for 15 minutes, filtered, and the filtrate was ultrafiltered with an ultrafiltration membrane, and the solution with a molecular weight cut-off of 5kD was separated to make an injection.

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Abstract

The invention discloses a bionic enzymatic product of horns and application thereof, which belong to the field of Chinese medicament. The bionic enzymatic product is characterized in that a bionic enzymatic method is adopted, and comprises the following steps: taking horns; grinding the horns into fine powders; adding water into the fine powders; evenly stirring the mixture; under appropriate condition, performing heat preservation by using pepsin; performing heat preservation by using pancreatin or trypsase; and preparing obtained zymolyte into preparations according to different preparationrequirements. The product of the invention has good effects in the aspects of clearing away heat and toxic material, cooling blood and hemostasis, diminishing inflammation, resisting infection and virus, arresting convulsion, and easing pain.

Description

technical field [0001] The invention relates to a bionic enzymatic hydrolysis product of traditional Chinese medicine animal horn and its application in medicines for clearing heat and detoxification, cooling blood for hemostasis, anti-inflammation, anti-infection, anti-virus, anticonvulsion and analgesia. It belongs to the field of traditional Chinese medicine. Background technique [0002] Animal horns have been used as traditional Chinese medicines for a long time and are widely used in clinical practice. Animal horns belong to the tissue derived from the skin, and their structure and composition are similar, and they are all composed of keratinocytes. Cornu Rhinoceri Asiatic and Cornu Rhinoceri African have the functions of clearing blood heat, detoxification, and relieving shock. Antelope horn Cornu Saigae Tataric is the horn of Saiga antelope Saigatatarica Linnaeus, an artiodactyl order of mammals. It has the functions of clearing heat and spasm, calming liver and wi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/32A61P7/04A61P29/00A61P31/04A61P31/12A61P43/00C12P21/00
Inventor 刘国飞周小明
Owner 北京凯瑞创新医药科技有限公司
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